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The Delineation of Antigenic Determinants of the Hemagglutinin of Influenza a Viruses by Means of Monoclonal Antibodies

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The Influenza Virus Hemagglutinin

Part of the book series: Topics in Infectious Diseases ((TIDIS,volume 3))

Summary

The antigenicity of various viral hemagglutinins (HA) of the HO and H1 subtypes was analyzed by means of monoclonal anti-HA antibodies of BALB/c origin which were produced in vitro. Anti-HA(PR8) antibodies were able to discriminate 44 (groups of) determinants, one specific for the HA of PR8 and the others present (in a crossreactive form) on a variable number of HA of the heterologous influenza virus strains. It was estimated that the 9 antigenically related HA included in the analysis represent a minimum of (2)7 antigenic determinants that are recognized by the BALB/c immune system, implying that the individual HA may contain approximately 15 to 65 distinct determinants.

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References

  • CRUMPTON, M. J. (1974) in `The Antigens’ (Ed., Sela, M.) Vol. II, 1–78. Academic Press.

    Google Scholar 

  • FAZEKAS DE ST. GROTH, S. (1967) Cold Spring Harbor Symposia on Quantative Biology, Vol. 32, 525–536.

    Article  Google Scholar 

  • GERHARD, W. (1976) J. Exp. Med. 144, 985–995.

    Article  PubMed  CAS  Google Scholar 

  • GERHARD, W., BRACIALE, T. J. and KLINMAN, N. R. (1975) Eur. J. Immunol. 5, 720.

    Article  PubMed  CAS  Google Scholar 

  • KLINMAN, N. R. and ASCHINAZI, G. (1971) J. Immunol. 106, 1338–1344.

    PubMed  CAS  Google Scholar 

  • LAVER, W. G., DOWNIE, J. C. and WEBSTER, R. G. (1974) Virology 59, 230–244.

    Article  PubMed  CAS  Google Scholar 

  • ROBBINS, J. B., HAIMOVICH, J. and SELA, M. (1967) Immunochemistry 4, 11–22.

    Google Scholar 

  • ROSENTHAL, I. D., HAYASHI, K. and NOTKINS, A. L. (1973) Appl. Microbiol. 2S, 567573.

    Google Scholar 

  • VIRELIZIER, J. L., ALLISON, A. C. and SCHILD, G. C. (1974) J. exp. Med. 140, 1571 1578.

    Google Scholar 

  • WRIGLEY, N. G., LAVER, W. G. and DOWNIE, J. C. (1977) J. Mol. Biol. 109, 405–421.

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. Walter Gerhard
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Editor information

Editors and Affiliations

  1. Microbiology Department, The John Curtin School of Medical Research, Canberra City, Australia

    William Graeme Laver

  2. Sandoz Forschungsinstitut Gesellschaft m. b. H., Vienna, Austria

    Helmut Bachmayer  & Rudolf Weil  & 

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© 1978 Springer-Verlag Wien

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Gerhard, W. (1978). The Delineation of Antigenic Determinants of the Hemagglutinin of Influenza a Viruses by Means of Monoclonal Antibodies. In: Laver, W.G., Bachmayer, H., Weil, R. (eds) The Influenza Virus Hemagglutinin. Topics in Infectious Diseases, vol 3. Springer, Vienna. https://doi.org/10.1007/978-3-7091-4130-4_2

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  • DOI: https://doi.org/10.1007/978-3-7091-4130-4_2

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-4132-8

  • Online ISBN: 978-3-7091-4130-4

  • eBook Packages: Springer Book Archive

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