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Über den Wirkungsmechanismus von Gonadotropin-releasing-Aktivität aus menschlichem Hypothalamus

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Zentralnervöse Sexualsteuerung

Part of the book series: Journal of Neuro-Visceral Relations ((NEURAL SUPPL,volume 10))

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Summary

The time aspects of the release of gonadotrophins were studied by means of an extremely pure preparation of tissue from the human hypothalamus.

The test animals used were Wistar rats which had been ovariectomized and blocked with oestrogen-progesterone. The release of FSH reached its maximum at 30 minutes after the administration of the test substance. After 90 minutes the FSH level had returned to its control levels. On the other hand, the LH level rose for 60 minutes and remained high at 120 minutes.

In similar experiments with oestrone sulphate the liberation of FSH and LH followed an identical pattern.

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Literatur

  • Heller, S., H. D. Schlumberger, and R. Blobel: Gonadotropin-releasing Activity in the Human Hypothalamus. 6. World Congr. Fertility and Sterility Tel Aviv 1968.

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  • Parlow, A. F.: In: Albert, A.: Human Pituitary Gonadotrophins. Springfield: Charles C. Thomas, 1961.

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  • Ramirez, V. D., and S. M. McCann: A highly sensitive test for LH-releasing activity: the ovariectomized, estrogen-progesteron-blocked rat. Endocrinology 73, 193–198 (1963).

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  • Schlumberger, H. D., and R. Blobel: Extraction and Purification of FSH-releasing-Faktor from Human Hypothalamus (in Vorbereitung).

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  • Steelman, S. L., and F. M. Pohley: Assay of the follicle stimulating hormone based on the augmentation with human chorionic gonadotropin. Endocrinology 53, 604–616 (1953).

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Authors and Affiliations

  1. Geburtshilflich-gynäkologische Abteilung, Ev. Diakonissenanstalt Schwäb. Hall, Universitäts-Frauenklinik Tübingen, Deutschland

    Doz. Dr. med. R. Blobel (Chefarzt), S. Heller, H. D. Schlumberger, F. Schumm & G. Ströbel

  2. Biochemische Abteilung, Max-Planck-Institutes für Virusforschung, Tübingen, Deutschland

    Doz. Dr. med. R. Blobel (Chefarzt), S. Heller, H. D. Schlumberger, F. Schumm & G. Ströbel

Authors
  1. Doz. Dr. med. R. Blobel
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  2. S. Heller
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  3. H. D. Schlumberger
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  4. F. Schumm
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  5. G. Ströbel
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H. Orthner

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© 1971 Springer-Verlag Wien

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Blobel, R., Heller, S., Schlumberger, H.D., Schumm, F., Ströbel, G. (1971). Über den Wirkungsmechanismus von Gonadotropin-releasing-Aktivität aus menschlichem Hypothalamus. In: Orthner, H. (eds) Zentralnervöse Sexualsteuerung. Journal of Neuro-Visceral Relations, vol 10. Springer, Vienna. https://doi.org/10.1007/978-3-7091-4157-1_9

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  • DOI: https://doi.org/10.1007/978-3-7091-4157-1_9

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-4158-8

  • Online ISBN: 978-3-7091-4157-1

  • eBook Packages: Springer Book Archive

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