Zusammenfassung
Chemische Bezeichnung: 0,0-dimethyl-(1hydroxy-2,2,2-trichloroethyl)-phosphonat.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Literatur
Abdi YA, Villén T (1991) Pharmacokinetics of metrifonate and its rearrangement product dichlorvos in whole blood. Pharmacol Toxicol 68: 137–139
Averbook BJ, Anderson RJ (1983) Electrophysiological changes associated with chronic administration of organophosphates. Arch Toxicol 52: 167–172
Bassant MH, Jazat-Poindessous F, Lamour Y (1996) Effects of metrifonate, a Cholinesterase inhibitor, on local cerebral glucose utilization in young and aged rats. J Cereb Blood Flow Metab 16: 1014–1025
Becker RE, Colliver J, Elble R, Feldman E, Giacobini E, Kumar V, Markwell S, Moriearty P, Parks R, Shillcutt SD, Unni L, Vicari S, Womack C, Zec RF (1990) Effects of metrifonate, a long-acting Cholinesterase inhibitor, in Alzheimer disease: report of an open trial. Drug Dev Res 19: 425–434
Becker RE, Moriearty P, Surbeck R, Unni L, Varney A, Vicary SA (1994) Second and third generation Cholinesterase inhibitors: clinical aspects. In: Giacobini E, Becker R (eds) Alzheimer disease: therapeutic strategies. Birkhäuser, Boston, pp 172–178
Becker RE, Colliver JA, Markwell SJ, Moriearty PL, Unni LK, Vicari S (1996) Double-blind placebo-controlled study of metrifonate, an acetylcholinesterase inhibitor, for Alzheimer disease. Alzheimer Dis Assoc Disord 10: 124–131
Bieber F, Creed Pettigrew L, Mas J, Schmitt F, Wermeling D (1995) Results of a phase IIa clinical trial with metrifonate. Psychopharmacol Bull 31: 554
Blair D, Hoadley EC, Hutson DH (1975) The distribution of dichlorvos in the tissues of mammals after its inhalation or intravenous administration. Toxicol Appl Pharmacol 31: 243–253
Blair D, Dix KM, Hunt PF, Thorpe E, Stevenson DE, Walker AIT (1976) Dichlorvos — a 2-year inhalation carcinogenesis study in rats. Arch Toxicol 35: 281–294
Blokland A, Hinz V, Schmidt BH (1995) Effects of metrifonate and tacrine in the spatial morris task and modified irwin test: evaluation of the efficacy/safety profile in rats. Drug Dev Res 36: 166–177
Bolle WR (1956) Neguvon®: ein äuβerlich und innerlich anwendbares Insektizid, Larvizid und Ascarizid. Veterinärmedizinische Nachrichten 3: 155–172
Cummings J, Bieber F, Mas J, Orazem J, Gulanski B (1997) Metrifonate in Alzheimer’s disease. Results of a dose-finding study. In: Iqbal K, Winblad B, Nishimura T, Takeda M, Wisniewski HM (eds) Alzheimer’s disease: biology, diagnosis and therapeutics. John Wiley and Sons, Chichester, pp 665–669
Dubois KP, Cotter GJ (1955) Studies on the toxicity and mechanism of action of dipterex. Arch Industr Health 11: 53–60
Edwards G, Breckenridge AM (1988) Clinical pharmakokinetics of antihelmintic drugs. Clin Pharmacokinet 15: 67–93
Hallak M, Giacobini E (1989) Physostigmine, tacrine and metrifonate: the effect of multiple doses on acetylcholine metabolism in rat brain. Neuropharmacology 28: 199–206
Hinz VC, Grewig S, Schmidt BH (1996a) Metrifonate and dichlorvos: effects of a single oral administration on Cholinesterase activity in rat brain and blood. Neurochem Res 21: 339–345
Hinz VC, Grewig S, Schmidt BH (1996b) Metrifonate induces Cholinesterase inhibition exclusively via slow release of dichlorvos. Neurochem Res 21: 331–337
Hofer W (1981) Chemistry of metrifonate and dichlorvos. Acta Pharmacol Toxicol 49: 7–14
Holmstedt B, Nordgren I, Sandoz M, Sundwall A (1978) Metrifonate: summary of toxicological and pharmacological information available. Arch Toxicol 41: 3–29
Itoh A, Nitta A, Hirose M, Hasegawa T, Nabeshima T (1997a) Effects of metrifonate on impairment of learning and dysfunction of cholinergic neuronal system in basal fore-brain-lesioned rats. Behav Brain Res 83: 165–167
Itoh A, Nitta A, Katono Y, Usui M, Naruhashi K, Iida R, Hasegawa T, Nabeshima T (1997b) Effects of metrifonate on memory impairment and cholinergic dysfunction in rats. Eur J Pharmacol 322: 11–19
Jones KH, Sanderson DM, Noakes DN (1968) Acute toxicity data for pesticides. World Rev Pest Control 7: 135–143
Kronforst-Collins MA, Moriearty PL, Ralph M, Becker RE, Schmidt B, Thompson LT, Disterhoft JF (1997) Metrifonate treatment enhances acquisition of eyeblink conditioning in aging rabbits. Pharmacol Biochem Behav 56: 103–110
Main AR (1979) Mode of action of anticholinesterases. Pharmacol Ther 6: 579–628
Metcalf RE, Fukuto RB, March RB (1959) Toxic action of dipterex® and DDVP in the house fly. J Econ Entomol 52: 44–49
Mori F, Cuadra G, Giacobini E (1995) Metrifonate effects on acetylcholine and biogenic amines in rat cortex. Neurochem Res 20: 1081–1088
Moriearty PL, Womack CL, Dick BW, Colliver JA, Robbs RS (1991) Stability of peripheral hematological parameters after chronic acetylcholinesterase inhibition in man. Am J Hematol 37: 280–282
Morris J, Cyrus P, Orazem J, Mas J, Bieber F, Gulanski B (1997) Metrifonate: potential therapy for Alzheimer’s disease. News session — Poster, 49. Annu Meet Am Acad Neurol, Boston, Apr 1997
Nordgren I, Holmstedt B, Bengtsson E, Finkel Y (1981) Plasma levels of metrifonate and dichlorvos during treatment of schistosomiasis with bilarcil. Acta Pharmacol Toxicol 48: 79–86
Nordgren I, Karlen B, Kimland M (1992) Metrifonate and tacrine: a comperative study on their effect on acetylcholin dynamics in mouse brain. Pharmacol Toxicol 71: 236–240
Ogane N, Giacobini E, Messamore E (1992) Preferential inhibition of acetylcholinesterase molecular forms in rat brain. Neurochem Res 17: 489–495
Pacheco G, Palacios-Esquivel R, Moss DE (1995) Cholinesterase inhibitors proposed for treating dementia in Alzheimer’s disease: selectivity toward human brain acetylcholinesterase compared with butyrylcholinesterase. J Pharmacol Exp Ther 274: 767–770
Reiner E, Plestina R (1979) Regeneration of Cholinesterase activities in humane and rats after inhibition of 0,0-dimethy1-2,2-dichlorovinyl phosphate. Toxicol Appl Pharmacol 49: 451–454
Reynolds JEF (1989) Martindale: the extra pharmacopoeia, 29th ed. The Pharmaceutical Press, London
Riekkinen P jr, Schmidt B, Stefanski R, Kuitunen J, Riekkinen M (1996) Metrifonate improves spatial navigation and avoidance behavior in scopolamine-treated, medial septum-lesioned and aged rats. Eur J Pharmacol 309: 121–130
Riekkinen M, Schmidt B, Riekkinen P jr (1997) Subchronic treatment increases the duration of the cognitive enhancement induced by metrifonate. Eur J Pharmacol 338: 105–110
Scali C, Giovannini MG, Bartolini L, Prosperi C, Hinz V, Schmidt BP, Pepeu G (1997) Effect of metrifonate on extracellular brain acetylcholine and object recognition in aged rats. Eur J Pharmacol 325: 173–180
Schmidt BH, Hinz VC, Blokland A, Van Der Staay F-J, Fanelli RJ (1996) Preclinical pharmacology of metrifonate: a promise for Alzheimer therapy. In: Becker R, Giacobini E (eds) Alzheimer disease: from molecular biology to therapy. Birkhäuser, Boston, pp 217–221
Schmidt BH, Hinz VC, Van Der Staay F-J (1997) Cognition enhancement by metrifonate: evidence from animal studies. In: Iqbal K, Winblad B, Nishimura T, Takeda M, Wisniewski HM (eds) Alzheimer’s disease: biology, diagnosis and therapeutics. John Wiley and Sons, Chichester, pp 781–786
Shekhar KC (1991) Schistosomiasis drug therapy and treatment considerations. Drugs 42: 379–405
Sherman M, Ross E (1961) Acute and subchronic toxicity of insecticides to chicks. Toxicol Appl Pharmacol 3: 521–533
Škrinjaric-Špoljar M, Simeon V, Reiner E (1973) Spontaneous reactivation and aging of di-methylphosphorylated acetylcholinesterase and cholinesterases. Biochim Biophys Acta 315: 363–369
Unni LK, Womack C, Hannant ME, Becker RE (1994) Pharmacokinetics and pharmacodynamics of metrifonate in humane. Meth Find Exp Clin Pharmacol 16: 285–289
Van Der Staay FJ, Hinz VC, Schmidt BH (1996a) Effects of metrifonate, its transformation product dichlorvos, and other organophosphorous and reference Cholinesterase inhibitors on Morris water escape behavior in young-adult rats. J Pharmacol Exp Ther 278: 697–708
Van Der Staay FJ, Hinz VC, Schmidt BH (1996b) Effects of metrifonate on escape and avoidance learning in young and aged rats. Behav Pharmacol 7: 56–64
Villén T, Abdi YA, Erricsson Ö, Gustafsson LL, Sjöquist F (1990) Determination of metrifonate and dichlorvos in whole blood using gas chromatography and gas chromatography-mass spectrometry. J Chromatogr 529: 309–317
Witter RF, Gaines TB (1963) Relationship between depression of brain or plasma Cholinesterase and paralysis in chicken caused by certain organic phosphorous compounds. Biochem Pharmacol 12: 1377–1386
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1999 Springer-Verlag Wien
About this chapter
Cite this chapter
Retz, W., Rösler, M. (1999). Metrifonat. In: Riederer, P., Laux, G., Pöldinger, W. (eds) Neuro-Psychopharmaka Ein Therapie-Handbuch. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6400-6_68
Download citation
DOI: https://doi.org/10.1007/978-3-7091-6400-6_68
Publisher Name: Springer, Vienna
Print ISBN: 978-3-7091-7315-2
Online ISBN: 978-3-7091-6400-6
eBook Packages: Springer Book Archive