Skip to main content
SpringerLink
Log in

Genetik des Mammacarcinoms

  • Chapter
Mammacarcinom

Part of the book series: Onkologie heute ((ONKOLOGIE))

  • 23 Accesses

Zusammenfassung

Der Nachweis, daß Krebs eine genetisch bedingte Erkrankung ist, gelang erst in diesem Jahrhundert und muß zu den wohl bedeutendsten Entwicklungen in der Onkologie gezählt werden. Epidemiologische, zytogenetische und molekulargenetische Untersuchungen stellen die Grundlagen der Erforschung genetischer Ursachen dar. Die Krebsentstehung geht von mindestens einer Zelle aus und beruht auf der Akkumulation mehrerer unabhängiger Mutationen (Bodmer und Tomlinson 1996).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 29.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 39.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Aarnio M, Mecklin JP, Aaltonen LA, Nystrom-Lahti M, Jarvinen HJ (1995) Life-time risk of different cancers in hereditary non-polyposis colorectal cancer (HNPCC) syndrome. Int J Cancer 64(6): 430–433

    Article  PubMed  CAS  Google Scholar 

  2. Bignell G, Micklem G, Stratton MR, Asworth A, Wooster R (1997) The BRC repeats are conserved in mammalian BRCA2 proteins. Hum Mol Genet 6(1): 53–58

    Article  PubMed  CAS  Google Scholar 

  3. Bodmer WF, Tomlinson I (1996) Population genetics of tumours. Ciba-Found-Symp 197: 181–189

    PubMed  CAS  Google Scholar 

  4. Bork P, Blomberg N, Nilges M (1996) Internal repeats in the BRCA2 protein sequence. Nat Genet 13: 22–23

    Article  PubMed  CAS  Google Scholar 

  5. Broca P (1866) Traite de tumeurs. Asselin, Paris

    Google Scholar 

  6. Breast Cancer Linkage Consortium (1997) Pathology of familial breast cancer: Differences between breast cancer in carriers of BRCA1 or BRCA2 mutations and sporadic cases. Lancet: 349: 1505–1510

    Article  Google Scholar 

  7. Bui TD, Tortora G, Ciardiello F, Harris AL (1997) Expression of Wnt5a is downregu-lated by extracellular matrix and mutated c-Ha-ras in the human mammary epithelial cell line MCF-10A. Biochem Biophys Res Commun 239(3): 911–917

    Article  PubMed  CAS  Google Scholar 

  8. Carlomagno C, Perrone F, Gallo C, De Laurentiis M, Lauria R, Morabito A, et al. (1996) c-erbB-2 overexpression decreases the benefit of adjuvant tamoxifen in early-stage breast cancer without axillary lymph node metastasis. J Clin Oncol 14(19): 2702–2708

    PubMed  CAS  Google Scholar 

  9. Chen JD, Giesler G, Birkholtz G, Lindblom P, Rubio C, Lindblom A (1998) The role of ataxia-telangiectasia (AT) heterozygotes in familial breast cancer. Cancer Res 58(7): 1376–1379

    PubMed  CAS  Google Scholar 

  10. Connor F, Bertwistle D, Mee PJ, Ross GM, Swift S, Grigorilva E, et al. (1997): Tumour genesis and a DNA repair defect in mice with a truncating Brca2 mutation. Nat Genet 17: 423–430

    Article  PubMed  CAS  Google Scholar 

  11. Falette N, Paperin MP, Treilleux I, Gratadour AC, Peloux N, Mignotte H, et al. (1998) Prognostic value of p53 gene mutations in a large series of node-negative breast cancer patients. Cancer Res 58(7): 1451–1455

    PubMed  CAS  Google Scholar 

  12. FitzGerald MG, Bean JM, Hedge SR, Unsal H, MacDonald DJ, Harkin DP, et al. (1997) Heterozygous ATM mutations do not contribute to early onset of breast cancer. Nat Genet 15(3): 307–310

    Article  PubMed  CAS  Google Scholar 

  13. Fontana X, Ferrari P, Namer M, Peysson R, Salanon Ch, Bussiere F (1994) C-erbB-2 gene amplification and serum level of c-erbB-2 oncoprotein at primary breast cancer diagnosis. Anticancer Res 14: 2099–2104

    PubMed  CAS  Google Scholar 

  14. Ford D, Easton DF, Stratton M, Narod S, Goldgar D, Devilee P, et al. (1998) Genetic heterogeneity and penetrance analysis of the BRCA1 and BRCA2 genes in breast cancer families. Am J Hum Genet 62: 676–689

    Article  PubMed  CAS  Google Scholar 

  15. Haraldsson K, Loman N, Zhang QX, Johannson O, Olsson H, Borg A (1998) BRCA2 germ-line mutations are frequent in male breast cancer patients without a family history of the disease. Cancer Reserch 58(7): 1367–1371

    CAS  Google Scholar 

  16. Hartmann LC, Ingle JN, Wold LE, Farr GH, Grill JP, Su JQ, et al. (1994) Prognostic value of c-erbB-2 overexpression in axillary lymph node positive breast cancer. Results from a randomized adjuvant treatment protocol. Cancer 74(11): 2956–2963

    Article  PubMed  CAS  Google Scholar 

  17. Johannson OT, Idvall I, Anderson C, Borg A, Barkadottir RJ, Olsson H (1997) Tumour biological features of BRCA1 induced breast and ovarian cancer. Eur J Cancer 33: 362–371

    Article  Google Scholar 

  18. Johannson OT, Ramstam J, Borg A, Olsson H (1998) Survival of BRCA1 breast and ovarian cancer patients: A population based study from southern Sweden. J Clin Oncol 16(2): 397–404

    Google Scholar 

  19. Kandioler-Eckersberger S, Taucher B, Steiner M, Mannhalter Ch, Jakesz R (1998) P53 genotype and mayor response to anthracyclin or Paclitaxel based neoadjuvant treatment in breast cancer patients. J Clin Oncol 17: 392a

    Google Scholar 

  20. Kastan M (1997) On the trail from p53 to a apoptosis? Nat-Genet 17(2): 130–131

    Article  PubMed  CAS  Google Scholar 

  21. Kleihues P, Schäuble B, zur Hausen A, et al. (1997) Tumors associated with p53 germ-line mutations: A synopsis of 91 families. Am J Pathol 150(1): 1–13

    PubMed  CAS  Google Scholar 

  22. Kuerbitz SJ, Plunkett BS, Walsh WV, Kastan MB (1992) Wildtype p53 is a cell cycle checkpoint determinant following irradiation. Proc Natl Acad Sci USA 89(16): 7491–7495

    Article  PubMed  CAS  Google Scholar 

  23. Li FP, Fraumeni Jr JF (1969) Soft-tissue sarcomas, breast cancer, and other neoplasms. A familial syndrome? Ann Intern Med 71(4): 747–752

    PubMed  CAS  Google Scholar 

  24. Liu T, Wahlberg S, Rubio C, Holmberg E, Gronberg H, Lindblom A (1998) DGGE screening of mutations in mismatch repair genes (hMSH2 and hMLH1) in 34 Swedish families with colorectal cancer. Clin Genet 53(2): 131–135

    Article  PubMed  CAS  Google Scholar 

  25. Lynch ED, Ostermeyer EA, Lee MK, Arena JF, Ji H, Dann J, Swisshelm K, et al. (1997) Inherited mutations in PTEN that are associated with breast cancer, cowden disease, and juvenile polyposis. Am J Hum Genet 61(6): 1254–1260

    Article  PubMed  CAS  Google Scholar 

  26. Miki Y, Swensen J, Shattuck-Eidens D, Futreal PA (1994) A strong candidate for the breast and ovarian cancer suspectibility gene BRCA1. Science 266(5182): 66–71

    Article  PubMed  CAS  Google Scholar 

  27. Patel KJ, Yu VPCC, Lee HS, Corcoran A, Thisthlethwite FC, Evans MJ, Colledge WH, Friedman LS, Ponder BAJ, Venkitaraman AR (1998) Involvement of Brca2 in DNA repair. Molecular Cell 1(3): 347–357

    Article  PubMed  CAS  Google Scholar 

  28. Rhei E, Kang L, Bogomoniy F, Federici MG, Borgen PI, Boyd J (1997) Mutation analysis of the putative tumor suppressor gene PTEN/MMAC1 in primary breast carcinomas. Cancer Res 57(17): 3657–3659

    PubMed  CAS  Google Scholar 

  29. Soong R, Iacopetta BJ, Harvey JM, Sterret GF, Dawkins HJ, Hahnel R, Robbins PD (1997) Detection of p53 gene mutation by rapid PCR-SSCP and its association with poor survival in breast cancer. Int J Cancer 74(6): 642–647

    Article  PubMed  CAS  Google Scholar 

  30. Strong LC, Williams WR, Tainsky MA (1992) The Li-Fraumeni syndrome: From clinical epidemiology to molecular genetics. Am J Epidemiol 135(2): 190–199

    PubMed  CAS  Google Scholar 

  31. Swift M (1997) Ataxia telangiectasia and risk of breast cancer (letter). Lancet 350(9079): 740

    Article  PubMed  CAS  Google Scholar 

  32. Tavtigian SV, Simard J, Rommens J, Couch F, Shattuck-Eidens D, Neuhausen S, et al. (1996) The complete BRCA2 gene and mutations in chromosome 13q-linked kindreds. Nat Genet 12: 333–337

    Article  PubMed  CAS  Google Scholar 

  33. Tsou HC, Teng DH, Ping XL, Brancoloni V, Davis T, Hu R, et al. (1997) The role of MMAC1 mutations in early-onset breast cancer: Causative in association with Cowden syndrome and excluded in BRCA1-negative cases. Am J Hum Genet 61(5): 1036–1043

    Article  PubMed  CAS  Google Scholar 

  34. Verhoog LC, Brekelmans CTM, Seynaeve C, van den Bosch LMC, Dahmen G, van Geel AN, et al. (1998) Survival and tumour characteristics of breast-cancer patients with germline mutations of BRCA1. Lancet 351(9099): 316–321

    Article  PubMed  CAS  Google Scholar 

  35. Wagner TMU, Moeslinger R, Scheiner O, Breiteneder H, Devilee P (1998) New mutation in Brca1 gene detected in Austrian HBOC family. Human Mutation Suppl 1: S323–S333

    Article  Google Scholar 

  36. Williams WR, Anderson DE (1985) Genetic epidemiolgy of breast cancer: Further clarification and a response to King and Elston. Genet Epidemiol 2(2): 170–176

    Article  PubMed  CAS  Google Scholar 

  37. Wooster R, Bignell G, Lancaster J, Swift S, Seal S, Mangion J (1995) Identification of the breast cancer suspectibility gene BRCA2. Nature 378(6559): 789–792

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Universitätsklinik für Frauenheilkunde, Abteilung für Spezielle Gynäkologie, Ludwig-Boltzmann-Institut für Klinisch-experimentelle Onkologie, Währinger Gürtel 18-20, A-1090, Wien, Österreich

    Dr. Teresa Wagner, Mag. Gudrun Langbauer, Dipl.-Ing. Elisabeth Fleischmann & Prof. Dr. Ernst Kubista

Authors
  1. Dr. Teresa Wagner
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Mag. Gudrun Langbauer
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Dipl.-Ing. Elisabeth Fleischmann
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Prof. Dr. Ernst Kubista
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Klinische Abteilung für Onkologie, Univ.-Klinik für Innere Medizin I Allgemeines Krankenhaus, Wien, Österreich

    Christoph Zielinski

  2. Klinische Abteilung für Allgemeinchirurgie, Univ.-Klinik für Chirurgie Allgemeines Krankenhaus, Wien, Österreich

    Raimund Jakesz

Rights and permissions

Reprints and permissions

Copyright information

© 1999 Springer-Verlag Wien

About this chapter

Cite this chapter

Wagner, T., Langbauer, G., Fleischmann, E., Kubista, E. (1999). Genetik des Mammacarcinoms. In: Zielinski, C., Jakesz, R. (eds) Mammacarcinom. Onkologie heute. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6402-0_2

Download citation

  • DOI: https://doi.org/10.1007/978-3-7091-6402-0_2

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-83168-7

  • Online ISBN: 978-3-7091-6402-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation