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Molecular characterization of Borna disease virus from naturally infected animals and possible links to human disorders

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Viral Zoonoses and Food of Animal Origin

Summary

In this review data are presented which indicate a high degree of genetic stability of BDV in his natural host, the horse. Despite this high degree of sequence conservation, variation in antigenicity was found, which did not influence the pathogenic properties of the virus. In addition, the correlation between BDV-seropositivity and a variety of psychiatric and neurological disorders in humans is discussed. In diagnostically unselected psychiatric patients we found a similar distribution of psychiatric disorders in BDV seropositives compared to seronegatives. Investigations of cerebrospinal fluid revealed cases of BDV encephalitis in BDV seropositive psychiatric and neurological patients. In contrast to others, we have found no evidence for the presence of BDV-RNA or BDV in human peripheral blood leucocytes.

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Author information

Authors and Affiliations

  1. Institut für Virologie, Giessen, Günzburg, Germany

    S. Herzog, I. Pfeuffer, K. Haberzettl & Dr. J. A. Richt

  2. Institut für Virologie, Marburg, Günzburg, Germany

    H. Feldmann

  3. Institut für Veterinär-Pathologie, Giessen, Günzburg, Germany

    K. Frese

  4. Bezirkskrankenhaus Günzburg, Universität Ulm, Günzburg, Günzburg, Germany

    K. Rechter

  5. Institut für Virologie, Frankfurterstrasse 107, D-35392, Giessen, Günzburg, Federal Republic of Germany

    Dr. J. A. Richt

Authors
  1. S. Herzog
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  2. I. Pfeuffer
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  3. K. Haberzettl
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  4. H. Feldmann
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  5. K. Frese
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  6. K. Rechter
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  7. Dr. J. A. Richt
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Editor information

Editors and Affiliations

  1. Institute of Medical Microbiology, Ludwig-Maximilians-University, Munich, Federal Republic of Germany

    Oskar-Rüger Kaaden , Claus-Peter Czerny  & Werner Eichhorn ,  & 

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© 1997 Springer-Verlag Wien

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Herzog, S. et al. (1997). Molecular characterization of Borna disease virus from naturally infected animals and possible links to human disorders. In: Kaaden, OR., Czerny, CP., Eichhorn, W. (eds) Viral Zoonoses and Food of Animal Origin. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6534-8_17

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  • DOI: https://doi.org/10.1007/978-3-7091-6534-8_17

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-83014-7

  • Online ISBN: 978-3-7091-6534-8

  • eBook Packages: Springer Book Archive

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