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Epithelium under stress

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Asthma

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Summary

Cultured bovine bronchial epithelial cells respond to thermal stress with induction of HSP 70 and this stress is associated with increased fibronectin release. We conclude that epithelial cells are capable of responding to stress and that altered release of mediators involved in repair may be part of the stress response. TGF-p may modulate HSP 70 expression, to which extent, however, needs further evaluation.

Epithelial cells play an important role in inflammatory processes such asthma and chronic bronchitis having the potential to communicate with a number of immune cells in order to help direct the inflammatory response.

In this context, epithelial cells influence processes in the airways including smooth muscle tone, inflammation, repair and fibrosis. Improved understanding of the role of epithelial cells in airway diseases will provide the means for more specific direction of new therapeutic strategies.

Zusammenfassung

Epithel unter Stress. Atemwegserkrankungen wie die chronische Bronchitis und das Asthma sind durch wiederholte Episoden der Atemwegsentzündung gekennzeichnet. Der Mechanismus bei der Reparation der entzündlichen Schäden ist heute noch weitgehend unklar, spielt aber eine Schlüsselrolle darin, ob bleibende Schäden wie die subepitheliale Fibrose sich entwickeln werden oder nicht. Moderne Konzepte deuten darauf hin, daß die Migration, Proliferation und Differenzierung der Atemwegsepithelien für die Reparation einer verletzten Oberfläche von essentieller Bedeutung sind.

Fibronektin, ein extrazelluläres Matrixglykoprotein, spielt eine bereits gut definierte Rolle bei zelluären Prozessen, welche für Reparationsmechanismen Bedeutung haben.

Hitzeschockproteine (HSPs, Streßprotein) werden in Säugetierzellen gebildet, wenn dieselben auf eine Reihe von Streßsituationen reagieren, wie etwa Hyperthermie, Hypoxie, Ischaemie und oxydative Schädigung. Bei Menschen zählt die Familie der 70 kD HSP zu den prominentesten Vertretern der Hitzeschockproteine.

HSPs sind jüngst im Atemwegsepithel gefunden worden, wo sie wohl eine weitere Schutzfunktion gegenüber Streß ausüben. In weiterer Folge konnte gezeigt werden, daß TGF-beta die Produktion von HSP vermehrt.

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Author information

Authors and Affiliations

  1. II. Medizinische Abteilung, Wilhelminenspital, Montleartstraße 37, A-1171, Wien, Austria

    Dr. W. R. Pohl

  2. University of Nebraska, Med. Ctr., Omaha, USA

    D. J. Romberger

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  1. Dr. W. R. Pohl
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  2. D. J. Romberger
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Editor information

Editors and Affiliations

  1. 2. Medizinische Abteilung mit Lungenkrankheiten und Tuberkulose, Wilhelminenspital, Wien, Österreich

    Friedrich Kummer

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© 1995 Springer-Verlag/Wien

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Pohl, W.R., Romberger, D.J. (1995). Epithelium under stress. In: Kummer, F. (eds) Asthma. Springer, Vienna. https://doi.org/10.1007/978-3-7091-7539-2_4

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  • DOI: https://doi.org/10.1007/978-3-7091-7539-2_4

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-82670-6

  • Online ISBN: 978-3-7091-7539-2

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