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Relationship between anemia and tumor hypoxia

  • Chapter
Recombinant Human Erythropoietin (rhEPO) in Clinical Oncology

Abstract

Hypoxia is a major and independent prognostic factor in solid cancers. Tissue hypoxia in tumors and normal tissue develops if the oxygen supply cannot satisfy the oxygen demand (Vaupel et al. 1989). The complex pathophysiological mechanisms have recently been reviewed (Höckel and Vaupel 2001). Hypoxia seems to represent a general pathophysiological phenomenon in solid cancers and is associated with more rapid malignant progression and poor prognosis (Höckel et al. 1996; Höckel and Vaupel 2001).

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Author information

Authors and Affiliations

  1. Department of Radiation Oncology, Martin-Luther-University Halle-Wittenberg, Dryanderstrasse 4-7, D-06097, Halle, Germany

    Prof. Dr. Jürgen Dunst

  2. Department of Radiation Oncology, Technical University Munich, Munich, Germany

    M. Molls

Authors
  1. Prof. Dr. Jürgen Dunst
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  2. M. Molls
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Correspondence to Jürgen Dunst .

Editor information

Editors and Affiliations

  1. Innere Klinik und Poliklinik (Tumorforschung), Westdeutsches Tumorzentrum, Essen, Universitätsklinikum, Essen, Deutschland

    M. R. Nowrousian

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© 2002 Springer-Verlag/Wien

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Dunst, J., Molls, M. (2002). Relationship between anemia and tumor hypoxia. In: Nowrousian, M.R. (eds) Recombinant Human Erythropoietin (rhEPO) in Clinical Oncology. Springer, Vienna. https://doi.org/10.1007/978-3-7091-7658-0_6

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  • DOI: https://doi.org/10.1007/978-3-7091-7658-0_6

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-7660-3

  • Online ISBN: 978-3-7091-7658-0

  • eBook Packages: Springer Book Archive

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