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Continuous dopaminergic stimulation with parenteral lisuride in complicated Parkinson’s disease

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Early Diagnosis and Preventive Therapy in Parkinson’s Disease

Part of the book series: Key Topics in Brain Research ((KEYTOPICS))

Summary

The parenteral infusion of lisuride in the treatment of fluctuations in complicated Parkinson’s disease is highly effective. We report about 18 patients, who were treated in our institutions. In our patient-group we observed a significant (p < 0.01) drop in the UPDRS—scores for rigor, akinesia and speech and for OFF-hours (− 30%), tremor remained nearly uneffected. Two deaths following myocardial infarction and pneumonia were not attributable to therapy. 6 patients experienced hallucinations, in 2 of these infusion had to be stopped. In 2 patients with drug-induced mental alterations these phenomena seemed to depend on the ratio of lisuride to levodopa as on the infusion-profile.

This new therapy is time-consuming and needs a highly individual approach, but remains most effective in the treatment of motor fluctuations and of dyskinesias, offering possibly even further insight into the pathogenesis of these phenomena.

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Author information

Authors and Affiliations

  1. Department of Neurology, University of Würzburg, Federal Republic of Germany

    Dr. S. Bittkau

  2. Department of Neurology, St. Josef University-Hospital, Bochum, Federal Republic of Germany

    I. R. Klewin & H. Przuntek

  3. Department of Neuroendocrinology, Schering AG, Berlin, Germany

    I. Suchy

Authors
  1. Dr. S. Bittkau
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  2. I. R. Klewin
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  3. I. Suchy
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  4. H. Przuntek
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Editor information

Editors and Affiliations

  1. St. Josef Hospital, University of Bochum, Bochum, Federal Republic of Germany

    Horst Przuntek

  2. Clinical Neurochemistry, Department of Psychiatry, University of Würzburg, Würzburg, Federal Republic of Germany

    Peter Riederer

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© 1989 Springer-Verlag/Wien

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Bittkau, S., Klewin, I.R., Suchy, I., Przuntek, H. (1989). Continuous dopaminergic stimulation with parenteral lisuride in complicated Parkinson’s disease. In: Przuntek, H., Riederer, P. (eds) Early Diagnosis and Preventive Therapy in Parkinson’s Disease. Key Topics in Brain Research. Springer, Vienna. https://doi.org/10.1007/978-3-7091-8994-8_42

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  • DOI: https://doi.org/10.1007/978-3-7091-8994-8_42

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-82080-3

  • Online ISBN: 978-3-7091-8994-8

  • eBook Packages: Springer Book Archive

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