Skip to main content
SpringerLink
Log in

Oxygen Free Radicals in the Genesis of Peritumoural Brain Oedema in Experimental Malignant Brain Tumours

  • Conference paper
Brain Edema VIII

Part of the book series: Acta Neurochirurgica ((NEUROCHIRURGICA,volume 51))

Summary

Disruption of blood brain barrier with increased vascular permeability is associated with genesis of peritumoural oedema. Oxygen free radicals play a role in increased vascular permeability. Recent studies have suggested that tumour cells can produce superoxide radicals and free radical scavengers such as superoxide dismutase (SOD) and catalase in tumour cells are impaired. In this study, we investigated the role of oxygen free radicals in the genesis of peritumoural brain oedema in experimental malignant brain tumours using V × 2 carcinoma cells and 9L glioma cells. In vitro data indicate that the V × 2 carcinoma cell and the 9L glioma cells produce superoxide radicals detected by nitroblue tetrazolium. Electron spin resonance spectroscopy using DMPO as a spin trap demonstrated that SOD activity was significantly lower in subcutaneous larger 9L glioma tumours than in normal brains and 9L glioma brain tumours.

In the subcutaneous tumours, SOD activity was lower in the central portion of the tumour than in the peripheral portion of the tumour.

In conclusion, we are not sure whether oxygen free radicals are major causative factors of peritumoural brain oedema, but the demonstration of oxygen free radicals in brain tumour cells needs further investigation.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Ikeda Y, Anderson JH, Long DM (1989) Oxygen free radicals in the genesis of traumatic and peritumoural brain oedema. Neurosurgery 24: 679–685

    Article  PubMed  CAS  Google Scholar 

  2. Long DM (1979) Capillary ultrastructure in human metastatic brain tumours. J Neurosurg 51: 53–58

    Article  PubMed  CAS  Google Scholar 

  3. Sun Yi, Oberley LW, Elwell JH, Sierra-Rivera E (1989) Antioxidant enzyme activities in normal and transformed mouse liver cells. Int J Cancer 44: 1028–1033

    Article  Google Scholar 

  4. Oberley LW, Buettner GR (1979) Role of superoxide dismutase in cancer: A review. Cancer Res 39: 1141–1149

    PubMed  CAS  Google Scholar 

  5. Hiramatsu M, Kohno M (1987) Determination of superoxide dismutase activity by electron spin resonance spectrometry using the spin trap method. Jeol News 23: 7–9

    Google Scholar 

  6. Halliwell B, Gutteridge JMC (1984) Review article. Oxygen toxicity, oxygen radicals, transition metals and disease. Biochem J 219: 1–14

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

    D. M. Long

  2. Department of Neurosurgery, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113, Japan

    Y. Ikeda

Authors
  1. Y. Ikeda
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. D. M. Long
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Neurosurgery, Bern, Switzerland

    Hans-J. Reulen

  2. Institut für chirurgische Forschung, Ludwig-Maximilians-Universität, Klinikum Grosshadern, München, Federal Republic of Germany

    Alexander Baethmann

  3. Department of Neurological Surgery, State University of New York at Stony Brook, New York, USA

    Joseph Fenstermacher

  4. Division of Neurosurgery, Medical College of Virginia, Richmond, Virginia, USA

    Anthony Marmarou

  5. Laboratory of Neuropathology and Neuroanatomical Sciences, National Institutes of Health, Bethesda, Maryland, USA

    Maria Spatz

Rights and permissions

Reprints and permissions

Copyright information

© 1990 Springer-Verlag

About this paper

Cite this paper

Ikeda, Y., Long, D.M. (1990). Oxygen Free Radicals in the Genesis of Peritumoural Brain Oedema in Experimental Malignant Brain Tumours. In: Reulen, HJ., Baethmann, A., Fenstermacher, J., Marmarou, A., Spatz, M. (eds) Brain Edema VIII. Acta Neurochirurgica, vol 51. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9115-6_48

Download citation

  • DOI: https://doi.org/10.1007/978-3-7091-9115-6_48

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-9117-0

  • Online ISBN: 978-3-7091-9115-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation