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Simultaneous and Sequential Treatment with Radiation and Hyperthermia: A Comparative Assessment

  • Chapter
Interstitial Hyperthermia

Abstract

Hyperthermia is a modality which on its own probably has no role to play in the curative treatment of tumours in humans (Overgaard, 1985). Its most likely clinical application is in combination with other cancer treatments, especially radiation. Numerous experimental studies have now established that moderate hyperthermia can enhance the response of animal tumours to ionizing radiation (for review, see Horsman and Overgaard, 1989). There is now also good evidence from clinical Phase I and II studies showing that heat can enhance the radiation effect to a significant degree in a variety of human tumours (Overgaard, 1989a). However, it is still not entirely clear as to how the radiation and heat should be combined clinically, in order to obtain the greatest therapeutic advantage. In the following chapter we would therefore like to discuss the basic mechanisms underlying the interaction between hyperthermia and radiation and then to consider how these modalities should be given to produce the maximal therapeutic benefit in a given clinical situation.

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Authors and Affiliations

  1. Department of Experimental Clinical Oncology, Danish Cancer Society, Aarhus, Denmark

    M. R. Horsman & J. Overgaard

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  1. M. R. Horsman
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  1. University Clinic of Radiotherapy, Vienna, Austria

    Leonore Handl-Zeller

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Horsman, M.R., Overgaard, J. (1992). Simultaneous and Sequential Treatment with Radiation and Hyperthermia: A Comparative Assessment. In: Handl-Zeller, L. (eds) Interstitial Hyperthermia. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9155-2_2

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  • DOI: https://doi.org/10.1007/978-3-7091-9155-2_2

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