Kinetics of inhibition of MAO-B by N-(2-aminoethyl)-p-chlorobenzamide (Ro 16-6491) and analogues

Mullan, E. L.; Williams, C. H.

doi:10.1007/978-3-7091-9324-2_40

E. L. Mullan⁶ &
C. H. Williams⁶

Part of the book series: Journal of Neural Transmission ((NEURAL SUPPL,volume 41))

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Summary

Ro 16-6491 is known to be a potent reversible inhibitor of human brain MAO-B. This compound and several analogues were tested for their effect on bovine liver MAO-B. It was found that in compounds where the amide bond of Ro 16-6491 was replaced by an ester bond an increase in potency of the order of 150–200 times was obtained.

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References

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Authors and Affiliations

Division of Biochemistry, Queen’s University, Belfast, UK
E. L. Mullan & C. H. Williams

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E. L. Mullan
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C. H. Williams
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Editors and Affiliations

Biochemistry Department, Trinity College, Dublin, Ireland
K. F. Tipton
Department of Pharmacology, Technion, Haifa, Israel
M. B. H. Youdim
School of Pharmacy and Biomedicai Sciences, University of Portsmouth, UK
C. J. Barwell
Department of Pharmacology, University of Cambridge, UK
B. A. Callingham
Department of Pharmacology and Clinical Pharmacology, University of Dundee, UK
G. A. Lyles

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Mullan, E.L., Williams, C.H. (1994). Kinetics of inhibition of MAO-B by N-(2-aminoethyl)-p-chlorobenzamide (Ro 16-6491) and analogues. In: Tipton, K.F., Youdim, M.B.H., Barwell, C.J., Callingham, B.A., Lyles, G.A. (eds) Amine Oxidases: Function and Dysfunction. Journal of Neural Transmission, vol 41. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9324-2_40

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DOI: https://doi.org/10.1007/978-3-7091-9324-2_40
Publisher Name: Springer, Vienna
Print ISBN: 978-3-211-82521-1
Online ISBN: 978-3-7091-9324-2
eBook Packages: Springer Book Archive

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