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PECAM: Regulating the start of diapedesis

  • Chapter
Adhesion Molecules: Function and Inhibition

Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

The molecules involved in the capturing, rolling, adhesion, and locomotion steps of leukocyte emigration have been described in earlier chapters in this book. PECAM is primarily involved in diapedesis — the step in which leukocytes squeeze in ameboid fashion between the tightly apposed endothelial cells that line the blood vessels at a site of inflammation. It is also the “point of no return” for the leukocyte. In vivo as viewed by intravital microscopy, the preceding steps of capturing, rolling, locomotion, and adhesion are reversible. Most leukocytes that enter a postcapillary venule at the site of inflammation are not captured; many of the leukocytes that do adhere to the endothelium release back into the circulation. Once the leukocyte commits to diapedesis, however, it continues to migrate into the inflamed tissue and does not return to the circulation — at least not as the same cell.

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Authors and Affiliations

  1. Department of Pathology and Laboratory Medicine and the Graduate Program in Immunology and Microbial Pathogenesis, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY, 10021, USA

    William A. Muller

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  1. La Jolla Institute for Allergy & Immunology, 9420 Athena Circle, La Jolla, CA, 92037, USA

    Klaus Ley

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Muller, W.A. (2007). PECAM: Regulating the start of diapedesis. In: Ley, K. (eds) Adhesion Molecules: Function and Inhibition. Progress in Inflammation Research. Birkhäuser Basel. https://doi.org/10.1007/978-3-7643-7975-9_8

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