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Coxsackievirus-induced murine myocarditis and immunomodulatory interventions

  • Chapter
Inflammatory Cardiomyopathy (DCMi)

Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

Human acute myocarditis (AMC) and its sequelae, inflammatory cardiomyopathy (DCMi), are mostly caused by cardiotropic viral infections in the Western world. Insights from coxsackievirus B (CVB)-induced experimental myocarditis have substantially contributed to a better understanding of the complex pathogenesis of myocarditis, and have also helped to explain the highly differential courses of human disease. Several inbred murine strains are available for modeling acute myocarditis and chronic ongoing myocarditis after intraperitoneal CVB inoculation. Acute, subacute and chronic phases can be differentiated. The onset and the differential courses of CVB-induced myocarditis are orchestrated by complex virus-host interactions. Several immunomodulatory regimens targeting key players of the innate and the adaptive immune system have unraveled the underlying mechanisms, and identified promising intervention strategies. The latter may, once they have been clinically evaluated, translate to novel treatment strategies for patients.

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Authors and Affiliations

  1. Department of Internal Medicine — Cardiology, University Hospital of Marburg and Giessen, Philipps-Universität Marburg, Baldinger Strasse 1, 35033, Marburg, Germany

    Michel Noutsias

  2. Heart & Stroke Medicine and Physiology, Institute of Circulatory and Respiratory Health, Canadian Institutes of Health Research, Toronto General Hospital, University of Toronto, Toronto, Canada

    Peter Liu

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  1. Michel Noutsias
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  1. Department of Cardiology and Pneumology, Charité—Universitätsmedizin Berlin Campus Benjamin Franklin, Hinderburgdamm 30, 12200, Berlin, Germany

    Heinz-Peter Schultheiss  & Michel Noutsias  & 

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Noutsias, M., Liu, P. (2010). Coxsackievirus-induced murine myocarditis and immunomodulatory interventions. In: Schultheiss, HP., Noutsias, M. (eds) Inflammatory Cardiomyopathy (DCMi). Progress in Inflammation Research. Birkhäuser Basel. https://doi.org/10.1007/978-3-7643-8352-7_4

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