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Kultivierung von Säugetierzellen

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Bioprozesstechnik

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Zusammenfassung

Die Kultivierung von Säugetierzellen hat in Verbindung mit der industriellen Anwendung der Gen- und Biotechnik eine große medizinische und wirtschaftliche Bedeutung erlangt. Viele Hundert Gene für Proteine wurden kloniert und in tierischen Zellen exprimiert. Eine stetig steigende Zahl von Proteinen ist bereits für die Anwendung am Menschen zugelassen bzw. wird für ihre Eignung als Arzneimittel geprüft. Im Jahr 1987 wurde Actilyse® für die Therapie des Herzinfarktes in den Markt eingeführt, als eines der ersten Medikamente dieser Art, das aus Säugetierzellkulturen gewonnen wurde. Seitdem wurden viele weitere Proteine als Medikamente zur Therapie von Krankheiten in hochreiner Form und in großen Mengen aus Zellkulturen hergestellt (Tabelle 11.1). Auch die Diagnose-Möglichkeiten konnten durch gentechnische Verfahren erheblich erweitert werden. Viele Substanzen, die zuvor aufwendig und meist unwirtschaftlich aus tierischen und menschlichen Geweben extrahiert werden mussten, können inzwischen gezielt und sicher aus Säugetierzellkulturen hergestellt werden.

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Authors and Affiliations

  1. Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorfer Straße 65, 88397, Biberach

    Dr.-Ing. Michael Howaldt, Dr. Franz Walz & Dr. Ralph Kempken

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  1. Dr.-Ing. Michael Howaldt
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  2. Dr. Franz Walz
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  3. Dr. Ralph Kempken
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  1. Haslangstraße 28, 80689, München

    Horst Chmiel

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© 2011 Spektrum Akademischer Verlag Heidelberg

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Howaldt, M., Walz, F., Kempken, R. (2011). Kultivierung von Säugetierzellen. In: Chmiel, H. (eds) Bioprozesstechnik. Spektrum Akademischer Verlag, Heidelberg. https://doi.org/10.1007/978-3-8274-2477-8_11

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