Skip to main content
SpringerLink
Log in

Somatic Stem Cells

  • Chapter
  • First Online:
Regenerative Medicine for the Inner Ear

  • 996 Accesses

Abstract

A number of somatic stem cells have been used in inner ear research. In this chapter, two stem cells, mesenchymal and hematopoietic stem cells, are the focus, because these stem cells have already utilized in clinical settings. Of mesenchymal stem cells, the potential of bone marrow- and adipose tissue-derived stem cells for the treatment of the inner ear is reviewed. As for hematopoietic stem cells, their contribution to the maintenance of inner ear cell circumstances is introduced.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 89.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Naito Y, Nakamura T, Nakagawa T, Iguchi F, Endo T, Fujino K, et al. Transplantation of bone marrow stromal cells into the cochlea of chinchillas. Neuroreport. 2004;15(1):1–4.

    Article  PubMed  Google Scholar 

  2. Sharif S, Nakagawa T, Ohno T, Matsumoto M, Kita T, Riazuddin S, et al. The potential use of bone marrow stromal cells for cochlear cell therapy. Neuroreport. 2007;18(4):351–4.

    Article  PubMed  Google Scholar 

  3. Kamiya K, Fujinami Y, Hoya N, Okamoto Y, Kouike H, Komatsuzaki R, et al. Mesenchymal stem cell transplantation accelerates hearing recovery through the repair of injured cochlear fibrocytes. Am J Pathol. 2007;171(1):214–26.

    Article  PubMed Central  PubMed  Google Scholar 

  4. Tona Y, Sakamoto T, Nakagawa T, Adachi T, Taniguchi M, Torii H, et al. In vivo imaging of mouse cochlea by optical coherence tomography. Otol Neurotol. 2014;35(2):e84–9.

    Article  PubMed  Google Scholar 

  5. Kitada M, Dezawa M. Induction system of neural and muscle lineage cells from bone marrow stromal cells; a new strategy for tissue reconstruction in degenerative diseases. Histol Histopathol. 2009;24(5):631–42.

    PubMed  Google Scholar 

  6. Liu ZJ, Zhuge Y, Velazquez OC. Trafficking and differentiation of mesenchymal stem cells. J Cell Biochem. 2009;106(6):984–91.

    Article  CAS  PubMed  Google Scholar 

  7. Kondo T, Johnson SA, Yoder MC, Romand R, Hashino E. Sonic hedgehog and retinoic acid synergistically promote sensory fate specification from bone marrow-derived pluripotent stem cells. Proc Natl Acad Sci U S A. 2005;102(13):4789–94.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  8. Kondo T, Matsuoka AJ, Shimomura A, Koehler KR, Chan RJ, Miller JM, et al. Wnt signaling promotes neuronal differentiation from mesenchymal stem cells through activation of Tlx3. Stem Cells. 2011;29(5):836–46.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  9. Ogita H, Nakagawa T, Sakamoto T, Inaoka T, Ito J. Transplantation of bone marrow-derived neurospheres into guinea pig cochlea. Laryngoscope. 2010;120(3):576–81.

    Article  PubMed  Google Scholar 

  10. Jeon SJ, Oshima K, Heller S, Edge AS. Bone marrow mesenchymal stem cells are progenitors in vitro for inner ear hair cells. Mol Cell Neurosci. 2007;34(1):59–68.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  11. Lin Z, Perez P, Sun Z, Liu JJ, Shin JH, Hyrc KL, et al. Reprogramming of single-cell-derived mesenchymal stem cells into hair cell-like cells. Otol Neurotol. 2012;33(9):1648–55.

    Article  PubMed Central  PubMed  Google Scholar 

  12. Wakao S, Kitada M, Kuroda Y, Shigemoto T, Matsuse D, Akashi H, et al. Multilineage-differentiating stress-enduring (Muse) cells are a primary source of induced pluripotent stem cells in human fibroblasts. Proc Natl Acad Sci U S A. 2011;108(24):9875–80.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  13. Wakao S, Akashi H, Kushida Y, Dezawa M. Muse cells, newly found non-tumorigenic pluripotent stem cells, reside in human mesenchymal tissues. Pathol Int. 2014;64(1):1–9.

    Article  CAS  PubMed  Google Scholar 

  14. Pileggi A, Xu X, Tan J, Ricordi C. Mesenchymal stromal (stem) cells to improve solid organ transplant outcome: lessons from the initial clinical trials. Curr Opin Organ Transplant. 2013;18(6):672–81.

    CAS  PubMed  Google Scholar 

  15. Shi Y, Hu G, Su J, Li W, Chen Q, Shou P, et al. Mesenchymal stem cells: a new strategy for immunosuppression and tissue repair. Cell Res. 2010;20(5):510–8.

    Article  CAS  PubMed  Google Scholar 

  16. Battiwalla M, Barrett AJ. Bone marrow mesenchymal stromal cells to treat complications following allogeneic stem cell transplantation. Tissue Eng B Rev. 2014;20(3):211–7.

    Google Scholar 

  17. Zhang HT, Liu ZL, Yao XQ, Yang ZJ, Xu RX. Neural differentiation ability of mesenchymal stromal cells from bone marrow and adipose tissue: a comparative study. Cytotherapy. 2012;14(10):1203–14.

    Article  CAS  PubMed  Google Scholar 

  18. Hsiao ST, Asgari A, Lokmic Z, Sinclair R, Dusting GJ, Lim SY, et al. Comparative analysis of paracrine factor expression in human adult mesenchymal stem cells derived from bone marrow, adipose, and dermal tissue. Stem Cells Dev. 2012;21(12):2189–203.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  19. Ostanin AA, Petrovskii YL, Shevela EY, Chernykh ER. Multiplex analysis of cytokines, chemokines, growth factors, MMP-9 and TIMP-1 produced by human bone marrow, adipose tissue, and placental mesenchymal stromal cells. Bull Exp Biol Med. 2011;151(1):133–41.

    Article  CAS  PubMed  Google Scholar 

  20. Yoshida A, Kitajiri S, Nakagawa T, Hashido K, Inaoka T, Ito J. Adipose tissue-derived stromal cells protect hair cells from aminoglycoside. Laryngoscope. 2011;121(6):1281–6.

    Article  CAS  PubMed  Google Scholar 

  21. Zhou Y, Yuan J, Zhou B, Lee AJ, Ghawji M, Yoo TJ. The therapeutic efficacy of human adipose tissue-derived mesenchymal stem cells on experimental autoimmune hearing loss in mice. Immunology. 2011;133(1):133–40.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  22. Sng J, Lufkin T. Emerging stem cell therapies: treatment, safety, and biology. Stem Cells Int. 2012;2012:521343.

    Article  PubMed Central  PubMed  Google Scholar 

  23. Lang H, Ebihara Y, Schmiedt RA, Minamiguchi H, Zhou D, Smythe N, et al. Contribution of bone marrow hematopoietic stem cells to adult mouse inner ear: mesenchymal cells and fibrocytes. J Comp Neurol. 2006;496(2):187–201.

    Article  PubMed Central  PubMed  Google Scholar 

  24. Sato E, Shick HE, Ransohoff RM, Hirose K. Expression of fractalkine receptor CX3CR1 on cochlear macrophages influences survival of hair cells following ototoxic injury. J Assoc Res Otolaryngol. 2010;11(2):223–34.

    Article  PubMed Central  PubMed  Google Scholar 

  25. Okano T, Nakagawa T, Kita T, Kada S, Yoshimoto M, Nakahata T, et al. Bone marrow-derived cells expressing Iba1 are constitutively present as resident tissue macrophages in the mouse cochlea. J Neurosci Res. 2008;86(8):1758–67.

    Article  CAS  PubMed  Google Scholar 

  26. Okano T, Nakagawa T, Ito J. Distribution of bone marrow-derived cells in the vestibular end organs and the endolymphatic sac. Acta Otolaryngol Suppl. 2010;563:88–94.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto, 606-8507, Japan

    Takayuki Nakagawa

Authors
  1. Takayuki Nakagawa
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Takayuki Nakagawa .

Editor information

Editors and Affiliations

  1. Department of Otolaryngology-Head and Neck Surgery, Kyoto University Graduate School of Medicine, Sakyo-ku, Kyoto, Japan

    Juichi Ito

Rights and permissions

Reprints and permissions

Copyright information

© 2014 Springer Japan

About this chapter

Cite this chapter

Nakagawa, T. (2014). Somatic Stem Cells. In: Ito, J. (eds) Regenerative Medicine for the Inner Ear. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54862-1_32

Download citation

  • DOI: https://doi.org/10.1007/978-4-431-54862-1_32

  • Published:

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-54861-4

  • Online ISBN: 978-4-431-54862-1

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation