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Leukotriene B4 Receptors

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Bioactive Lipid Mediators

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Abstract

Leukotriene B4 (LTB4) is a classical pro-inflammatory lipid mediator that activates and recruits neutrophils into inflammatory areas. LTB4 is an arachidonic acid-derived metabolite produced by 5-lipoxygenase and LTA4 hydrolase. To date, two leukotriene B4 receptors, the high-affinity receptor BLT1 and the low-affinity receptor BLT2, have been cloned, and a systemic knockout mouse for each receptor has been generated. BLT1 is mainly expressed in leukocytes, but BLT2 is expressed in epithelial cells. Based on many knockout mouse studies, BLT1 is now known to play important roles in acute and chronic inflammation and immune diseases. On the other hand, BLT2 protects against colitis, accelerates epidermal wound healing, and promotes cancer progression. Thus, BLT1 and BLT2 have totally different features with respect to their expression patterns and their physiological and pathological roles. In this review, we summarize the fundamental characteristics of BLT1 and BLT2, as well as recent advances in our understanding of the biosynthesis and degradation of LTB4 and the LTB4 receptors.

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Authors and Affiliations

  1. Department of Biochemistry, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan

    Tomoaki Koga & Takehiko Yokomizo

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  1. Tomoaki Koga
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  2. Takehiko Yokomizo
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Correspondence to Takehiko Yokomizo .

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Editors and Affiliations

  1. Department of Biochemistry, Juntendo University Graduate School of Medicine, Tokyo, Japan

    Takehiko Yokomizo

  2. Lipid Metabolism Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan

    Makoto Murakami

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Koga, T., Yokomizo, T. (2015). Leukotriene B4 Receptors. In: Yokomizo, T., Murakami, M. (eds) Bioactive Lipid Mediators. Springer, Tokyo. https://doi.org/10.1007/978-4-431-55669-5_6

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