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Control of Chronic Inflammation Through Elucidation of Organ-Specific Autoimmune Disease Mechanisms

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Chronic Inflammation

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Abstract

Our body is equipped with an immune system that normally distinguishes between microorganisms (non-self) and components of our body (self), thereby protecting us from the invasion by many pathogens. However, intractable autoimmune disease, in which somehow our immune system attacks our own body, could develop by unknown mechanisms. With aiming toward novel therapeutic approaches to chronic inflammation caused by autoimmunity, we are studying the mechanisms underlying the development of organ-specific autoimmune diseases caused by the abnormal function of antigen-presenting cells in the thymus. We are particularly interested in how the immunological self is presented to developing thymocytes to establish the self-tolerance within the thymic microenvironment. NF-κB activation pathway in medullary thymic epithelial cells (mTECs) and Aire in mTECs, a transcription factor which is responsible for the development of rather rare hereditary type of autoimmune disease, are the main focus of our research, hoping that manipulations of those factors could control the chronic inflammation observed in many organ-specific autoimmune diseases.

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Authors and Affiliations

  1. Division of Molecular Immunology, Institute for Enzyme Research, Tokushima University, Tokushima, 770-8503, Japan

    Mitsuru Matsumoto

  2. AMED-CREST, Tokushima, 770-8503, Japan

    Mitsuru Matsumoto

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  1. Mitsuru Matsumoto
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Correspondence to Mitsuru Matsumoto .

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Editors and Affiliations

  1. Interdisciplinary Program for Biomedical Sciences Institute for Academic Initiatives, Osaka University, Suita, Japan

    Masayuki Miyasaka

  2. Department of Immunobiology and Pharmacological Genetics Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan

    Kiyoshi Takatsu

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Matsumoto, M. (2016). Control of Chronic Inflammation Through Elucidation of Organ-Specific Autoimmune Disease Mechanisms. In: Miyasaka, M., Takatsu, K. (eds) Chronic Inflammation. Springer, Tokyo. https://doi.org/10.1007/978-4-431-56068-5_37

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