Abstract
In this chapter, we provide an overview of our in silico modeling approaches based on a bottom-up perspective to understanding bone adaptation. For investigating the underlying cellular mechanism, we propose a mathematical model of trabecular bone remodeling that considers cellular mechanosensing and intercellular communication. Through remodeling simulations, this model is able to explain the phenomenological remodeling law to achieve locally uniform mechanical states at the tissue level. Furthermore, we present a model for trabecular surface remodeling based on the hypothesis that bone remodeling is driven by the local non-uniformity of stress distribution on the trabecular surface. The trabecular remodeling simulations incorporating this phenomenological model can successfully represent the functional adaptation of the trabecular architecture from the tissue level to the organ level.
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Kameo, Y., Tsubota, Ki., Adachi, T. (2018). Overview: In Silico Approaches to Understand Bone Adaptation. In: Bone Adaptation. Frontiers of Biomechanics, vol 2. Springer, Tokyo. https://doi.org/10.1007/978-4-431-56514-7_1
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