Abstract
Human skin is a remarkably efficient barrier, creating difficulties for the penetration of exogenous substances. Only drugs with suitable physicochemical properties, such as those of low molecular weight and having a moderate partition coefficient, can permeate adequately through skin to exert pharmacological effects. Among the techniques for enhancing the permeation of drugs with unfavorable properties, the ion-pair strategy provides a simple approach without modification of drug structure or change in skin barrier function. By forming ion pairs with counter ions, the partition coefficient of drugs is regulated to a level that is suitable to permeate through skin.
This chapter introduces the concept of ion pairs and the important factors influencing the formation of ion pairs. Based on the available reports of applying the ion-pair strategy, the effects of the ion-pair strategy on the transdermal delivery of both lipophilic and hydrophilic drugs are summarized. Furthermore, the possible mechanism of action of the ion-pair strategy in enhancing drug transdermal delivery is also illustrated.
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Fang, L., Song, W. (2017). Related Topic: Ion-Pair Strategy. In: Sugibayashi, K. (eds) Skin Permeation and Disposition of Therapeutic and Cosmeceutical Compounds. Springer, Tokyo. https://doi.org/10.1007/978-4-431-56526-0_20
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DOI: https://doi.org/10.1007/978-4-431-56526-0_20
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