Abstract
After almost fifty years suxamethonium is still widely used for a variety of short operations where rapid onset and short action are advantageous [1]. Its drawbacks are well known and widely understood but it has long been recognised that a competitive agent with rapid onset and short action would be preferable. However, the rational design of any such agent depends on an ability to correlate these effects with particular aspects of chemical structure in a way that does not detract from the other essential requirements of a safe and effective neuromuscular blocking agent.
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References
Norman J. Neuromuscular blocking agents of the future. In: Bowman WC, Denissen PAF, Feldman F, eds. Neuromuscular blocking agents: past, present and future. Proceedings of the David Savage Memorial Interface Symposium, London 1990. Amsterdam: Excerpta Medica, 1990; 15–19.
Bowman WC, Rodger IW, Houston J, Marshall RJ, Mclndewar I. Structure: act ion relationships among some desacetoxy analogues of pancuronium and vecuronium in the anesthet ised cat. Anesthesiology 1988 ; 69: 57–62.
Hughes R, Payne JP. Clinical assessment of atracurium using the single twitch and tetanic responses of the adductor policis muscle. Br. J.Anaesth. 1983 ; 55: 47S–52S.
Muir AW, Marshall RJ. Comparat ive neuromuscular blocking effects of vecuronium, pancuronium, Org 6368 and suxamethonium in the anaesthetised domestic pig. Br. J.Anaesth. 1987 ; 59: 622–629.
Savarese JJ. The clinical pharmacology of mivacurium. In: Bowman WC, Denissen PAF, Feldman F. eds. Neuromuscular blocking agents: past, present and future. Amsterdam: Excerpta Medica, 1990; 69–78.
Stenlake JB, Waigh RD, Dewar GH, Hughes R. Chapple DJ, Coker GG. Biodegradable neuromuscular blocking agents. Part 4. Atracurium besylate and related polyalkylene di-esters) Eur J Med Chem 1981 ; 16: 515–524.
Stenlake JB, Hughes R. In vitro degradation of atracurium in human plasma. Br J Anaesth 1987; 59: 806–810.
Stenlake JB, Dhar NC. Haddow J, McDonald IM, Maehr RB, Wastila WB. Neuromuscular blocking agents. Some approaches to short acting compounds. Eur J Med Chem 1992; 27: 463–477.
Albert, A. Heterocyclic Chemistry. London: Athlone Press, 1959; 223–224.
Iacono JM, Johnson BC. Thiamine metabolism 1. The metabolism of thiazole-2-[C] 14[D]C-thiamine in the rat. J Am Chem Soc 1957 ; 79: 6321–6324.
Amoswh, Neal A. Isolation and identificat ion of 3 (2-methyl-4-amino-5-pyrimidylmethyl)-4-methyl thiazole-5-acetic acid (thiamine acetic acid) and 2-methyl-4-amino-5-formylaminomethylpyrimidine as metabolites of thiamine in the rat. J Biol Chem 1970; 245: 5643–5648
Stenlake JB. Dhar NC. Henderson CF. Maehr RB, Scharver J. Wastila WB. Midgley JM. Neuromuscular blocking agents. Approaches to short acting compounds 2. Bis-thiazolium salts. Eur J Med Chem 1993 ; 28: 415–418
Kharkevich DA, Skoldinev AP, Lemina EY, Igumnova ND. Re lat ions between structure, hydrolysis rate and activity of dicarboxylic esters. Farmakol Toxicol (Moscow) 1989: 52: 34–37(C.A. 110: 205078t)
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Stenlake, J.B. (1995). Approaches to Short-Acting Neuromuscular Blocking Agents. In: Fukushima, K., Ochiai, R. (eds) Muscle Relaxants. Springer, Tokyo. https://doi.org/10.1007/978-4-431-66896-1_9
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DOI: https://doi.org/10.1007/978-4-431-66896-1_9
Publisher Name: Springer, Tokyo
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