Abstract
Recent evidence suggests that the methylation of specific cytosine residues in DNA is an important factor in regulating gene expression and differentiation in eukaryotes [1, 2]. Alterations in the levels and patterns of 5-methyldeoxycytidine have been implicated in many of the basic gene processes of mammalian cells involved in embryogenesis, carcinogenesis, and cell differentiation [3, 4]. Hypomethylation of regulatory regions of genes is often associated with enhanced transcriptional activity during carcinogenesis [5, 6]. The compiled evidence for this view is based mainly upon the development of tumors elicited by choline-deflcient diets which decrease the availability of substrates for DNA methylations in animal models.
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© 1991 Springer-Verlag Tokyo
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Jain, S.K., Suzuki, K., Jain, S., Sugiyama, T., Taniguchi, N. (1991). Hypomethylation-Associated Expression of Cytochrome P-450 and γ-Glutamyl Transpeptidase During Hereditary Hepatocarcinogenesis in LEC Rats. In: Mori, M., Yoshida, M.C., Takeichi, N., Taniguchi, N. (eds) The LEC Rat. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68153-3_18
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DOI: https://doi.org/10.1007/978-4-431-68153-3_18
Publisher Name: Springer, Tokyo
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