Summary
It was confirmed that hyperalgesia in the paw and tail-pressure tests is induced by repeated cold stress (RCS) in rats and mice. The RCS-induced hyperalgesia in rats was inhibited by intrathecal injection of anti-substance P antibody or anti-calcitonin gene-related peptide (CGRP) antiserum, but not by anti-galanin antiserum, while hyperalgesia induced by carrageenan in rats was inhibited by all antibody-antisera to the neuropeptides described above. These results suggest that enhancement of synaptic transmission mediated by substance P and CGRP, but not galanin, in the spinal dorsal horn is partly involved at least in RCS-induced hyperalgesia. On the other hand, RCS-induced hyperalgesia in mice was inhibited by various Kampo medicines such as Mao-bushi-saishin-to (TJ-127), Hachimi-jio-gan (TJ-7), Sho-saiko-to (TJ-9), Tokishakuyaku-san (TJ-23), Keishi-to (TJ-45), Goshaku-san (TJ-63), and Kei-kyo-zo-so-o-shin-bu-to (TJ-8023) but not by Juzen-taiho-to (TJ-48) which is seldom used in the treatment of painful states. Thus, hyperalgesia induced by RCS in mice may be a useful model for evaluating the analgesic action of Kampo medicines.
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© 1994 Tsutomu Oyama
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Satoh, M. (1994). Basic Research in Pain and Kampo Medicines. In: Oyama, T., Smith, G. (eds) Pain and Kampo. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68260-8_1
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DOI: https://doi.org/10.1007/978-4-431-68260-8_1
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