Skip to main content
SpringerLink
Log in

Histamine-induced leukocytosis

  • Chapter
New Advances in Histamine Research

  • 85 Accesses

Abstract

From the early years of the introduction of H2 antagonists for clinical uses, many reports have been published that H2 antagonists induce various kinds of cytopenia, such as neutropenia, agranulocytosis, thrombocytopenia, pancytopenia and lymphopenia. At the present time, it has become evident that histamine exerts a stimulative effect on the differentiation and proliferation of bone marrow stem cells, especially in neutrophil progenitors, via an H2 receptor stimulation (Tasaka, 1991). However, as early as 8 years before the discovery of the H2 receptor and histamine H2 antagonist by Black et al. (1972), Tasaka and Code (1964) reported that chronic injection of histamine induces leukocytosis in various kinds of experimental animals. This was the first report which clearly pointed out the hematopoietic action of histamine in vivo. A growing body of evidence indicates that histamine is not only a physiological hematopoietic substance but also that it interacts with other hematopoietic cytokines, such as granulocytic colony stimulating factor (G-CSF) and interleukin-1α (IL-1), at physiological concentration range. The stimulative effect of histamine on several leukemia cells has also been reported (Nonaka et al., 1992). In this chapter, the mechanism of histamine-induced leukocytosis is reviewed.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Adachi K., Aoyagi T., Iizuka H., Halprin K.M. and Levine V. (1980) Cyclic GMP system in the epidermis. Curr. Probl. Dermatol., 10: 39–65

    PubMed  CAS  Google Scholar 

  • Akiyama Y., Mukai T., Kamei C. and Tasaka K. (1990) Histamine lipolysis I: Changes in the free fatty acid levels of dog plasma after intravenous infusion of histamine. Meth. Find. Exp. Clin. Pharmacol., 12: 315–324

    CAS  Google Scholar 

  • Bainton D.F., Ullyot J.L. and Farquhar M.G. (1971) The development of neutrophilic polymorphonuclear leukocytes in human bone marrow. J. Exp. Med., 134: 907–934

    Article  PubMed  CAS  Google Scholar 

  • Black J.W., Duncan W.A.M., Durant G.J., Gannelin C.R. and Parsons M.E.: Definition and antagonism of histamine H2-receptors. Nature, 236: 385–390

    Google Scholar 

  • Burgess A.W. and Metcalf D. (1980) The nature and action of granulocyte-macrophage colony stimulating factors. Blood, 56: 947–958

    PubMed  CAS  Google Scholar 

  • Burtin C. (1986) Mast cells and tumour growth. Ann. Inst. Pasteur Immunol., 137D: 289–294

    PubMed  CAS  Google Scholar 

  • Burtin C., Scheinmann P., Salomon J.C., Lespinats G., Frayssinet C., Lebel B. and Canu P. (1981) Increased tissue histamine in tumour-bearing mice and rats. Br. J. Cancer, 43: 684–688

    Article  PubMed  CAS  Google Scholar 

  • Byron J.W. (1976) Bone-marrow toxicity of metiamide. Lancet, 2: 1350

    Article  PubMed  CAS  Google Scholar 

  • Byron J.W. (1980) Pharmacodynamic basis for the interaction of cimetidine with the bone marrow stem cells (CFU-S). Exp. Hematol., 8: 256–263

    PubMed  CAS  Google Scholar 

  • Catini C., Gheri G., Giampaoli M. and Miliani A. (1984) Histamine uptake by leukocytes in vitro. Basic Appl. Histochem., 28: 329–336

    PubMed  CAS  Google Scholar 

  • Chaplinski T.J. and Niedel J.E. (1986) Cyclic AMP levels and cellular kinetics during maturation of human promyelocytic leukemia cell. J. Leukocyte Biol., 39: 323–331

    PubMed  CAS  Google Scholar 

  • Clark R.A.F., Gallin J.I. and Kaplan A. (1975) The selective eosinophil chemotactic activity of histamine. J. Exp. Med., 142: 1462–1476

    Article  PubMed  CAS  Google Scholar 

  • Code C.F. (1976) Suppression of histamine leucocytosis by metiamide. J. Physiol. (Lond.) 254: 31P-32P

    Google Scholar 

  • Collins S.J., Ruscetti F.W., Gallagher R.E. and Gallo R.C. (1978) Terminal differentiation of human promyelocytic leukemia cells induced by dimethylsulfoxide and other polar compounds. Proc. Natl. Acad. Sci. USA, 75: 2458–2462

    Article  PubMed  CAS  Google Scholar 

  • de Galoscy C. and van Ypersele de Strihou C. (1979) Pancytopenia with cimetidine. Ann. Intern. Med., 90: 274

    Google Scholar 

  • Deutsch P.J., Rosen O.M. and C.S. Rubin (1982) Identification and characterization of a latent pool of insulin receptors in 3T3-L1 adipocytes. J. Biol. Chem., 257: 5350–5358

    PubMed  CAS  Google Scholar 

  • Dexter T.M., Allen T.D. and Lajtha L.G. (1977) Conditions controlling the proliferation of haemopoietic stem cells in vitro. J. Cell. Physiol., 91: 335–344

    Article  PubMed  CAS  Google Scholar 

  • Dexter T.M. and Testa N.G. (1976) Differentiation and proliferation of hemopoietic cells in culture. Methods Cell Biol. 14: 387–405

    Article  PubMed  CAS  Google Scholar 

  • Dinarello C.A. (1988) Interleukin-1. Ann. N.Y. Acad. Sci., 546: 122–132

    Article  PubMed  CAS  Google Scholar 

  • Dinarello C.A., Ikejima T., Warner S.J.C., Orencole S.F., Lonnemann G., Cannon J.G. and Libby P. (1987) Interleukin 1 induces interleukin 1. J. Immunol., 139: 1902–1910

    PubMed  CAS  Google Scholar 

  • Dunn A.R. (1987) The role of growth factors in normal and neoplastic haemopoiesis. Ann. N. Y. Acad. Sci. 511: 1–9

    Article  PubMed  CAS  Google Scholar 

  • Evans S.W., Rennick D. and Farrar W.L. (1987) Identification of a signal-transduction pathway shared by haematopoietic growth factors with diverse biological specificity. Biochem. J., 244: 683–691

    PubMed  CAS  Google Scholar 

  • Feldman E.J. and Isenberg J.I. (1976) Effects of metiamide on gastric acid hypersecretion, steatorrhea and bone-marrow function in a patient with systemic mastocytosis. N. Engl. J. Med., 295: 1178–1179

    Article  PubMed  CAS  Google Scholar 

  • Fibbe W.E., Damme J.V., Billiau A., Goselink H.M., Voogt P.J., Eeden G.V., Ralph P., Altrock B.W. and Falkenburg J.H.F. (1988) Interleukin 1 induces human marrow stromal cells in long-term culture to produce granulocyte colony-stimulating factor and macrophage colony-stimulating factor. Blood 71: 430–435

    PubMed  CAS  Google Scholar 

  • Fleming W.A. and McNeill T.A. (1976) Cellular responsiveness to stimulation in vitro. Increased responsiveness to colony stimulating factor of bone marrow colony forming cells treated with surface active agents and cyclic 3′, 5′AMP. J. Cell Physiol. 88: 323–330

    Article  PubMed  CAS  Google Scholar 

  • Forrest J.A.H., Shearman D.J.C., Spence R. and Celestin L.R. (1975) Neutropenia associated with metiamide. Lancet, 1: 392–393

    Article  PubMed  CAS  Google Scholar 

  • Gespach C., Saal F., Cost H. and Abita J.P. (1982) Identification and characterization of surface receptors for histamine in the human promyelocytic leukemia cell line HL-60. Comparison with human peripheral neutrophils. Mol. Pharmacol., 22: 547–553

    PubMed  CAS  Google Scholar 

  • Gespach C., Marrec N. and Belitrand N. (1985a) Relationship between 3H-histamine uptake and H2-receptors in the human promyelocytic leukemia cell line HL-60. Agents Actions, 16: 279–283

    Article  PubMed  CAS  Google Scholar 

  • Gespach C., Cost H. and Abita J.-P. (1985b) Histamine H2 receptor activity during the differentiation of the human monocytic-like cell line U-937. Comparison with prostaglandins and isoproterenol. FEBS Lett., 184: 207–213

    Article  PubMed  CAS  Google Scholar 

  • Gespach C., Courillon-Mallet A., Launay J.M., Cost H. and Abita J.-P. (1986b) Histamine H2 receptor activity and histamine metabolism in human U-937 monocyte-like cells and human peripheral monocytes. Agents Actions, 18: 124–128

    Article  PubMed  CAS  Google Scholar 

  • Gowda S.D., Koler R.D. and Bagby G.C. Jr. (1986) Regulation of c-myc expression during growth and differentiation of normal and leukemic human myeloid progenitor cells. J. Clin. Invest., 77: 271–278

    Article  PubMed  CAS  Google Scholar 

  • Graham H.T., Lowry O.H., Wheelwright F., Lenz M.A. and Parish H.H. Jr. (1955) Distribution of histamine among leukocytes and platelets. Blood, 10: 467–481

    PubMed  CAS  Google Scholar 

  • Harper R.A., Flaxman B.A. and Chopra D.P. (1974) Mitotic response of normal and psoriatic keratinocytes in vitro to compounds known to affect intracellular cAMP. J. Invest. Dermatol., 62: 384–387

    Article  PubMed  CAS  Google Scholar 

  • Hatamochi A., Fujiwara K. and Ueki H. (1985) Effects of histamine on collagen synthesis by cultured fibroblasts derived from guinea pig skin. Arch. Dermatol. Res., 277: 60–64

    Article  PubMed  CAS  Google Scholar 

  • Hay L.J., Vacro R.L., Code C.F. and Wangensteen O.H. (1942) The experimental production of gastric and duodenal ulcers in laboratory animals by the intramuscular injection of histamine in beeswax. Surg. Gynecol. Obstet., 75: 170–182

    CAS  Google Scholar 

  • Hidaka H., Inagaki M., Kawamoto S. and Sakai Y. (1984) Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C. Biochemistry, 23: 5036–5041

    Article  PubMed  CAS  Google Scholar 

  • Idvall J. (1979) Cimetidine-associated thrombocytopenia. Lancet, 2: 159

    Article  PubMed  CAS  Google Scholar 

  • Iizuka H., Adachi K., Halprin K.M. and Levine V. (1978) Cyclic AMP accumulation in psoriatic skin: differential responses to histamine. AMP and epinephrine by the uninvolved and involved epidermis. J. Invest. Dermatol., 70: 250–253

    Article  PubMed  CAS  Google Scholar 

  • Imaizumi, M. and Breitman, T.R. (1988) Changes in c-myc, c-fms and N-ras proto-oncogene expression associated with retinoic acid-induced monocytic differentiation of human leukemia. Cancer Res., 48: 6733–6738

    PubMed  CAS  Google Scholar 

  • Johnson M.McI., Black A.E., Hughes A.S.B. and Clarke S.W. (1977) Leucopenia with cimetidine. Lancet, 2: 1226–1227

    Article  Google Scholar 

  • Kase H., Iwahashi K., Nakanishi S., Matsuda Y., Yamada K., Takahashi M., Murakata C., Sato A. and Kaneko M. (1987) K-252 compounds, novel and potent inhibitors of protein kinase C and cyclic nucleotide-dependent protein kinases. Biochem. Biophys. Res. Commun., 142: 436–440

    Article  PubMed  CAS  Google Scholar 

  • Kiss Z., Deli E., Vogler W.R. and Kuo J.F. (1987) Anti-leukemic agent alkyllysophospholipid regulates phosphorylation of distinct proteins in HL-60 and K-562 cells and differentiation of HL-60 cells prompted by phorbol ester. Biochem. Biophys. Res. Commun., 42: 661–666

    Article  Google Scholar 

  • Klotz S.A. and Kay B.F. (1978) Cimetidine and agranulocytosis. Ann. Intern. Med., 88: 579–580

    PubMed  CAS  Google Scholar 

  • Knight D.E. and Scrutton M.C. (1984) Cyclic nucleotides control a system which regulates Ca2+ sensitivity of platelet secretion. Nature, 309: 66–68

    Article  PubMed  CAS  Google Scholar 

  • Kobayasi Y., Appella E., Yamada M., Copeland T.D., Oppenheim J.J. and Matsushima K. (1988) Phosphorylation of intracellular receptors of human IL-1. J. Immunol., 140: 2279–2287

    Google Scholar 

  • Koeffler H.P. (1983) Induction of differentiation of human acute myelogenious leukemia cells: Therapeutic implications. Blood, 62: 709–721

    PubMed  CAS  Google Scholar 

  • Lanotte M., Metcalf D. and Dexter T.M. (1982) Production of monocyte/macrophage colony- stimulating factor by preadipocyte cell lines derived from murine marrow stroma. J. Cell. Physiol., 112: 123–127

    Article  PubMed  CAS  Google Scholar 

  • Liebermann D.A. and Hoffman-Liebermann B. (1989) Proto-oncogene expression and dissection of the myeloid growth to differentiation developmental cascade. Oncogene, 4: 583–592

    PubMed  CAS  Google Scholar 

  • Lin H.-S., Lokekshwar B.L. and Hsu J.R. (1989) Both granulocyte-macrophage CSF and macrophage CSF control the proliferation and survival of the same subset of alveolar macrophages. J. Immunol., 142: 515–519

    PubMed  CAS  Google Scholar 

  • Lingberg S. and Tönqvist Å. (1966) The inhibitory effect of aminoguanidine on histamine catabolism in human pregnancy. Acta Obstet. Gynecol. Scand., 45: 131–139

    Article  Google Scholar 

  • Lotem J. and Sachs L. (1987) Regulation of cell-surface receptors for hematopoietic differentiation-inducing protein MGI-2 on normal and leukemic myeloid cells. Int. J. Cancer, 40: 532–539

    Article  PubMed  CAS  Google Scholar 

  • Marks R.M., Roche W.R., Czemiecki M., Penny R. and Nelson D.S. (1986) Mast cell granules cause proliferation of human micro vascular endothelial cells. Lab. Invest., 55: 289–294

    PubMed  CAS  Google Scholar 

  • Maslinski C.Z., Kierska D., Sasiak K. and Adamas B. (1984) Histamine and its catabolism in tumor-bearing rat and mouse. Agents Actions, 14: 497–500

    Article  PubMed  CAS  Google Scholar 

  • McCachren S.S. Jr., Nichols J., Kaufman R.E. and Niedel J.E. (1986) Dibutyric cyclic adenosine monophosphate reduces expression of c-myc during HL-60 differentiation. Blood, 68: 412–416

    PubMed  CAS  Google Scholar 

  • Mochizuki D.Y., Eisenman J.R., Conlon P.J., Larsen A.D. and Tushinski R.J. (1987) Interleukin 1 regulates hematopoietic activity, a role previously ascribed to hemopoietin 1. Proc. Natl. Acad. Sci. USA 84: 5267–5271

    Article  PubMed  CAS  Google Scholar 

  • Nakao S., Matsushima K. and Young N. (1989) Decreased interleukin 1 production in aplastic anaemia. Br. J. Haematol., 71: 431–436

    Article  PubMed  CAS  Google Scholar 

  • Nakaya N. and Tasaka K. (1988a) The influence of histamine on precursors of granulocytic leukocytes in murine bone marrow. Life Sci., 42: 999–1010

    Article  PubMed  CAS  Google Scholar 

  • Nakaya N. and Tasaka K. (1988b) Histamine incorporation into murine myeloblasts and promyelocytes. Formation of a histamine transport system. Biochem. Pharmacol., 37: 4523–4530

    Article  PubMed  CAS  Google Scholar 

  • Nicola N.A., Peterson L., Hilton D.J. and Metcalf D. (1988) Cellular processing of murine colony-stimulating factor (multi-CSF, GM-CSF, G-CSF) receptors by normal hemopoietic cells and cell lines. Growth Factors, 1, 41–49

    Article  PubMed  CAS  Google Scholar 

  • Nomura H., Imazeki I., Oheda M., Kubota N., Tamura M., Ono M., Ueyama Y. and Asano S. (1986) Purification and characterization of human granulocyte colony-stimulating factor (G-CSF). EMBO J., 5: 871–876

    PubMed  CAS  Google Scholar 

  • Nonaka T., Mio M., Doi M. and Tasaka K. (1992) Histamine-induced differentiation of HL-60 cells. The role of cAMP and protein kinase A. Biochem. Pharmacol., 44: 1115–1121

    Article  PubMed  CAS  Google Scholar 

  • Ohta Y., Akiyama T., Nishida E. and Sakai H. (1987) Protein kinase C and c AMP- dependent protein kinase induce opposite effects on actin polymerizability. FEBS Lett, 222: 305–310

    Article  PubMed  CAS  Google Scholar 

  • Platzer E., Simon S. and Kalden J.R. (1988) Human granulocyte colony stimulating factor: Effects of human long-term bone marrow cultures. Blood Cells, 14: 463–469

    PubMed  CAS  Google Scholar 

  • Plet A., Evain D. and Anderson W.B. (1982) Effect of retinoic acid treatment of F9 embryonal carcinoma cells on the activity and distribution of cAMP dependent protein kinase. J. Biol. Chem., 257: 889–893

    PubMed  CAS  Google Scholar 

  • Radermecker M. and Maldague M.-P. (1981) Depression of neutrophil chemotaxis in atopic individuals. An H2 histamine receptor response. Int. Arch. Allergy Appl. Immunol., 65: 144–152

    Article  PubMed  CAS  Google Scholar 

  • Rapoport A.P., Abboud C.N. and DiPersio J.F. (1992) Granulocyte-macrophage colony- stimulating factor (GM-CSF) and granulocyte colony-stimulating factor (G-CSF): Receptor biology, signal transduction, and neutrophil activation. Blood Rev., 6: 43–57

    Article  PubMed  CAS  Google Scholar 

  • Rocklin R.E. and Haberek-Davidson A. (1981) Histamine activates suppressor cells in vitro using a coculture technique. J. Clin. Immunol., 1: 73–79

    Article  PubMed  CAS  Google Scholar 

  • Rocklin R.E., Greineder D. and Melmon K.L. (1979) Histamine-induced suppressor factor (HSF): further studies on the nature of the stimulus and the cell which produces it. Cell. Immunol., 44: 404–415

    Article  PubMed  CAS  Google Scholar 

  • Rosenwasser L.J. and Dinarello C.A. (1981) Ability of human leukocytic pyrogen to enhance hemagglutinin induced murine thmocyte proliferation. Cell. Immunol., 63: 134–142

    Article  PubMed  CAS  Google Scholar 

  • Salehi Z., Taylor J.D. and Niedel J.E. (1988) Dioctanoylglycerol and phorbol esters regulate transcription of c-myc in human promyelocytic leukemia cells. J. Biol. Chem., 263: 1898–1903

    PubMed  CAS  Google Scholar 

  • Sawutz D.G., Kalinyak K., Whitsett J.A., Johnson C.L. (1984) Histamine H2-receptor desensitization in HL-60 human promyelocytic leukemia cells. J. Pharmacol. Exp. Ther., 231: 1–7

    PubMed  CAS  Google Scholar 

  • Schwartz J.-C., Arrang J.-M., Bouthenet M.-L., Garbarg M., Pollard H. and Raut M. (1991) Histamine receptors in brain, in ‘Handbook of Experimental Pharmacology, vol. 97. Histamine and histamine antagonists’ (ed. Uväns B.), Springer-Verlag, Berlin, pp. 191–242

    Google Scholar 

  • Spotts G.D. and Hann S.R. (1990) Enhanced translocation and increased turnover of c-myc proteins occur during differentiation of murine erythroleukemia cells. Mol. Cell. Biol., 10: 3952–3964

    PubMed  CAS  Google Scholar 

  • Tasaka K. (1991) Histamine and the Blood, in ‘Handbook of Experimental Pharmacology, vol. 97. Histamine and histamine antagonists’ (ed. Uvnäs B.), Springer-Verlag, Berlin, pp. 473–510

    Google Scholar 

  • Tasaka K. and Code C.F. (1964) Histamine leukocytosis. Fed. Proc. 23: 471

    Google Scholar 

  • Tasaka K. and Nakaya N. (1987) The relationship between incorporation of histamine and differentiation of neutrophil progenitors in murine bone marrow. Agents Actions, 20: 320–323

    Article  PubMed  CAS  Google Scholar 

  • Tasaka K., Nakaya N. and Code C.F. (1992a) Histamine leukocytosis. I. Effect of histamine on peripheral leukocyte counts. Meth. Find. Exp. Clin. Pharmacol., 14: 667–675

    CAS  Google Scholar 

  • Tasaka K., Shorter R.G. and Code C.F. (1992b) Histamine leukocytosis. II. Source of histamine leukocytosis. Meth. Find. Exp. Clin. Pharmacol., 14: 799–804

    CAS  Google Scholar 

  • Tasaka K., Mio M., Shimazawa M. and Nakaya N. (1993) Histamine-induced production of interleukin-lor from murine bone marrow stromal cells and its inhibition by H2 blockers. Mol. Pharmacol., 43: 365–371

    PubMed  CAS  Google Scholar 

  • Tasaka K., Doi M., Nakaya N. and Mio M. (1994) Reinforcement effect of histamine on the differentiation of murine myeloblasts and promyelocytes: Extemalization of G-CSF receptors induced by histamine. Mol. Pharmacol., 45: 837–845

    PubMed  CAS  Google Scholar 

  • Voorhees J.J., Duell E.A., Bass L.J., Powell J.A. and Harrell E.R. (1972) The cyclic AMP system in normal and psoriatic epidermis. J. Invest. Dermatol.,59: 114–120

    Article  PubMed  CAS  Google Scholar 

  • Walker F., Nicola N.A., Metcalf D. and Burgess A.W. (1985) Hierarchical down-modulation of hemopoietic growth factor receptors. Cell, 43: 269–276

    Article  PubMed  CAS  Google Scholar 

  • Zsebo K.M., Yuschenkoff V.N., Schiffer S., Chang D., McCall E., Dinarello C.A., Brown M.A., Altrock B. and Bagby G.C. (1988) Vascular endothelial cells and granulopoiesis: Interleukin-1 stimulates release of G-CSF and GM-CSF. Blood 71: 99–103

    PubMed  CAS  Google Scholar 

  • Zucali J.R., Dinarello C.A., Obion D.J., Gross M.A., Anderson L. and Weiner R.S. (1986) Interleukin 1 stimulates fibroblasts to produce granulocyte-macrophage colony-stimulating activity and prostaglandin E2. J. Clin. Invest., 77: 1857–1863

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. The Department of Pharmacology in the Faculty of Pharmaceutical Sciences, Okayama University, 1-1-1, Tsushima-Naka, 700, Okayama, Japan

    Kenji Tasaka M.D., PH.D. (Chairman and Professor)

Authors
  1. Kenji Tasaka M.D., PH.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 1994 Springer-Verlag Tokyo

About this chapter

Cite this chapter

Tasaka, K. (1994). Histamine-induced leukocytosis. In: New Advances in Histamine Research. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68263-9_8

Download citation

  • DOI: https://doi.org/10.1007/978-4-431-68263-9_8

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-68265-3

  • Online ISBN: 978-4-431-68263-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation