Abstract
Fibrinolytic therapy for cerebral embolism was initially accomplished by intravenous administration of urokinase and streptokinase. Although this was technically easy, results were far from satisfactory; no significant change was seen in treated patients compared with the control group, and mortality rate was high among the treated group [1]. Therefore, this method was abandoned. In recent years, clinical trials in treating patients with cerebral embolism by intravenous administration of a new fibrinolytic agent recombinant tissue plasminogen activator (rt-PA), which has a strong affinity to fibrin in the embolus, have been done. This was said to be effective compared to the control group, but the reported recanalization rate, which was 30%–50%, was not yet satisfactory [2,3]. Furthermore, this seems to be more effective for small emboli lodging in the cortical branches than large emboli lodging in the more proximal arteries.
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References
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© 1995 Springer-Verlag Tokyo
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Goto, K., Ogata, N. (1995). “Central” Intraarterial Thrombolysis Using a Newly Developed Low Friction Guidewire/Catheter System. In: Yamaguchi, T., Mori, E., Minematsu, K., del Zoppo, G.J. (eds) Thrombolytic Therapy in Acute Ischemic Stroke III. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68459-6_35
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DOI: https://doi.org/10.1007/978-4-431-68459-6_35
Publisher Name: Springer, Tokyo
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