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Pharmacogenomics and Personalized Medicine in Alzheimer’s Disease

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Omics for Personalized Medicine

Abstract

Alzheimer’s disease (AD) and related dementias, neurodegenerative disorders accompanied by progressive deterioration of cognitive capacity, every-day behavior abilities, and integrity of brain tissue, present an ever-growing, worldwide dilemma due to aging populations confronted by a related neuropathology. The “amyloid cascade hypothesis,” that pathophysiology is driven by the ever-increasing burden of β-amyloid in the brains of afflicted patients, involves a poorly understood orchestration encompassing multitudes of enzymes and signaling pathways arranged in vast and diverse arrays of cellular processes, and vascular considerations all of which are under the control of predictive genes and susceptibility genes that describe genetic and genes x environmental epigenetic interactions. Genetic aspects of these disorders and the intricacies of pharmacogenomics implicated several neurotransmitter pathways, circuits and regional brain developments, and metabolism that reinforce the growing requirements for personalized medicine. The search for individual-based medication, in addition to genomic assay and biomarker identity, seeks to establish a “reregulation” of destructive β-amyloid pathways, an understanding and application of Aβ-linked immunotherapy, the initiation and formulation of pharmacogenetic/pharmacogenomics principles and methodologies, the emergence of the role of apolipoprotein (APOE) in therapeutic endeavor, the assessment and treatment of behavioral and psychological symptoms, the therapies focused upon frontotemporal dementia, and the interventions centered around instrumental activities of daily activities.

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  1. Department of Psychology, University of Gothenburg, 500, SE 450 30, Gothenburg, Sweden

    Trevor Archer & Boo Johansson

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    Debmalya Barh

  2. Institute of Life Sciences, B.V. Patel Pharmaceutical Education and Research Development Centre, Ahmedabad University, Ahmedabad, Gujarat, India

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  3. Policy Centre for Biomedical Research, Translational Health Science and Technology Institute (Department of Biotechnology Institute, Government of India), Office @ National Institute of Immunology, New Delhi, India

    Nirmal Kumar Ganguly

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Archer, T., Johansson, B. (2013). Pharmacogenomics and Personalized Medicine in Alzheimer’s Disease. In: Barh, D., Dhawan, D., Ganguly, N. (eds) Omics for Personalized Medicine. Springer, New Delhi. https://doi.org/10.1007/978-81-322-1184-6_15

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