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Endophytic Fungi: Novel Sources of Anticancer Molecules

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Advances in Endophytic Research

Abstract

Cancer is an enormous global health burden, touching every region of the world. The term “anticancer” is based on the assessment of the authors of the paper of the cytotoxicity of each compound against specific cancer cell lines. Endophytic fungi, fungi that are residing asymptomatically in internal tissues of all higher plants, are of growing interest as promising sources of biologically active agents. Endophytic fungi are one of the most creative groups of secondary metabolite producers that play important biological roles for human life. This chapter mainly focuses on endophytic fungi, which produce anticancer bioactive compounds such as paclitaxel, podophyllotoxin, camptothecin, vinblastine, hypericin, and diosgenin. The uniqueness of the endophytic community of fungi is stressed as a promising source of novel compounds with anticancer activity. Endophytes represent a dependable source of specific secondary metabolites and can be manipulated both physicochemically and genetically to increase yields of desired metabolites and to produce novel analogues of active metabolites.

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Acknowledgment

The authors are thankful to the Director, NBAIM, for providing the necessary facilities and support for this work.

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  1. National Bureau of Agriculturally Important Microorganisms, Kushmaur, 6, Kaithauli, Mau Nath Bhanjan, 275 101, Uttar Pradesh, India

    Vinod Kumar, Shalini Rai, Pallavi Gaur & Tayaba Fatima

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  1. Vinod Kumar
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  2. Shalini Rai
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  3. Pallavi Gaur
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  4. Tayaba Fatima
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Correspondence to Vinod Kumar .

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  1. Centre of Experimental Medicine and Surgery (CEMS), Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India

    Vijay C. Verma

  2. School of Biological Sciences, Royal Holloway University of London, Egham, Surrey, United Kingdom

    Alan C. Gange

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Kumar, V., Rai, S., Gaur, P., Fatima, T. (2014). Endophytic Fungi: Novel Sources of Anticancer Molecules. In: Verma, V., Gange, A. (eds) Advances in Endophytic Research. Springer, New Delhi. https://doi.org/10.1007/978-81-322-1575-2_20

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