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Marine Sponge-Derived Antiangiogenic Compounds for Cancer Therapeutics

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Marine Sponges: Chemicobiological and Biomedical Applications

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Abstract

The biological properties of various metabolites from sponges reported recently and marine sponges are considered as a gold mine for past 50 years. Sponge-derived compounds and their metabolites have different types of biological activity such as antimicrobial, antiinflammatory, antimalarial, antioxidant, anti-HIV, and anticancer activity. Angiogenesis is the important process in tumor progression. The term “angiogenic switch” refers to a very important event during the tumor progression between pro- and antiangiogenic factors. Angiogenesis and its mechanistic pathway targeting may be useful for therapeutic approach for cancer. Recent times many compounds from marine sources have proven important role against cancer. These compounds inhibit cell proliferation and angiogenesis of cancer. In this chapter, we discuss the antiangiogenic compounds isolated from marine sponge that work against cancer.

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Authors and Affiliations

  1. Department of Nuclear Medicine, Kyungpook National University School of Medicine, Jung-Gu, Daegu, 700 842, Republic of Korea

    Kalimuthu Senthilkumar & Byeong-Cheol Ahn

  2. Department of Neuroscience, Christian Medical College and Hospital, Vellore, 632 004, India

    Govindan Ramajayam

  3. Specialized Graduate School Science and Technology Convergence, Department of Marine Bio Convergence Science, Pukyong National University, Busan, 608-737, Republic of Korea

    Jayachandran Venkatesan & Se-Kwon Kim

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  1. Kalimuthu Senthilkumar
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  2. Govindan Ramajayam
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  3. Jayachandran Venkatesan
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  4. Se-Kwon Kim
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  5. Byeong-Cheol Ahn
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Correspondence to Kalimuthu Senthilkumar .

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  1. IKP Knowledge Park, Hyderabad, Telangana, Andhra Pradesh, India

    Ramjee Pallela

  2. Biomineralogy & Extreme Biomimetics, Institute of Experimental Physics, Freiberg, Sachsen, Germany

    Hermann Ehrlich

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Senthilkumar, K., Ramajayam, G., Venkatesan, J., Kim, SK., Ahn, BC. (2016). Marine Sponge-Derived Antiangiogenic Compounds for Cancer Therapeutics. In: Pallela, R., Ehrlich, H. (eds) Marine Sponges: Chemicobiological and Biomedical Applications. Springer, New Delhi. https://doi.org/10.1007/978-81-322-2794-6_14

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