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Immunological Parameters of Nutrition

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Cachexia and Wasting: A Modern Approach

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Abstract

The interdependency between nutrition and immune function was recognised formally in the 1970s when immunological measures were introduced as part of the assessment of nutritional status [1]. Both the nutritional status and specific nutrients may affect the immune system directly (e.g., by triggering immune cell activation or altering immune cell interactions) or indirectly (e.g., by changing substrates for DNA synthesis, altering energy metabolism, changing the physiological integrity of cells, or altering signals or hormones) [2]. Protein-energy malnutrition is accepted as a major cause of immune deficiency worldwide, and the immune response is considered integral to the pathophysiology of many chronic diseases [3]. Protein-energy malnutrition is associated with a significant impairment of cellmediated immunity, phagocyte function, complement system, secretory immunoglobulin A antibody concentrations and cytokine production.

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Authors and Affiliations

  1. Department of Medical Oncology, University of Cagliari, Cagliari, Italy

    Clelia Madeddu & Giovanni Mantovani

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  1. Clelia Madeddu
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  2. Giovanni Mantovani
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Editor information

Editors and Affiliations

  1. Department of Medical Oncology, University of Cagliari, Cagliari, Italy

    Giovanni Mantovani

  2. Department of Clinical Cardiology, Imperial College, NHLI, London, UK

    Stefan D. Anker

  3. Department of Cardiology Charité, Applied Cachexia Research, Campus Virchow-Klinikum, Berlin, Germany

    Stefan D. Anker

  4. Department of Behavioral Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan

    Akio Inui

  5. GRECC, VA Medical Center and Division of Geriatric Medicine, Saint Louis University, St. Louis, MO, USA

    John E. Morley

  6. Department of Clinical Medicine, University of Rome, La Sapienza, Rome, Italy

    Filippo Rossi Fanelli

  7. Department of Infectious Diseases, IRCCS S.Matteo Polyclinic, University of Pavia, Pavia, Italy

    Daniele Scevola

  8. Bone Marrow and Blood Stem Cell Transplantation Program, Center for Lymphoma and Myeloma, New York Presbyterian Hospital/Weill Medical Center, New York, NY, USA

    Michael W. Schuster

  9. Department of Medicine-Geriatrics, University of New York at Stony Brook VAMC, Northport, NY, USA

    Shing-Shing Yeh

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Madeddu, C., Mantovani, G. (2006). Immunological Parameters of Nutrition. In: Mantovani, G., et al. Cachexia and Wasting: A Modern Approach. Springer, Milano. https://doi.org/10.1007/978-88-470-0552-5_11

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