Abstract
Intrahepatic stone disease, or hepatolithiasis, is a disease with distinctive epidemiological, pathogenetic and therapeutic features. This disease is rare in Western countries, whereas it is endemic in some Asian countries. It is defined as presence of gall-stones in intrahepatic the bile ducts, proximal to bile duct bifurcation [1]. Hepatolithiasis is primary when stones are formed de novo in the intrahepatic bile ducts, whereas it is secondary when extrahepatic gallstones migrate into the intrahepatic bile ducts [2–4]. The disease is associated with biliary stricture, primary disease of bile ducts (primitive sclerosing cholangitis, Caroli’s disease, choledochal cysts), neoplasm or parasitic infestation.
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References
Mori T, Sugiyama M, Atomi Y (2006) Gallstone disease: management of intrahepatic stones. Best Pract Res Clin Gastroenterol 20:1117–1137
Leung JW, Yu AS (1997) Hepatolithiasis and biliary parasites. Baillieres Clin Gastroenterol 11:681–706
Pridgen JE Jr, Aust JB, McInnis WD (1977) Primary intrahepatic gallstones. Arch Surg 112:1037–1043
Saunders KD, Cates JA, Roslyn JJ (1990) Pathogenesis of gallstones. Surg Clin North Am 70:1197–1216
Nakayama F, Keida Y et al (1987) The survey of hepatolithiasis. Annual reports of the Japanese Ministry of Health and Welfare, Tokyo, Japan. Japanese Government p 37
Ozawa K, Takabayashi Y et al (1992) The survey of hepatolithiasis. Annual reports of the Japanese Ministry of Health and Welfare, Tokyo, Japan. Japanese Government (37):11
Tanimura H (1997) The survey of hepatolithiasis. Annual reports of the Japanese Ministry of Health and Welfare, Tokyo, Japan. Japanese Government, 1997: p 8
Lindstrom CG (1977) Frequency of gallstone disease in a well-defined Swedish population. A prospective necropsy study in Malmo. Scand J Gastroenterol 12:341–346
Simi M, Loriga P, Basoli A (1979) Intrahepatic lithiasis. Study of thirty-six cases and review of the literature. Am J Surg 137:317–322
Pitt HA, Vebrux AC, Coleman J (1994) Intrahepatic stones. The transhepatic team approach. Ann Surg 219:527–535; discussion 535–537
Nakayama F, Furusawa T, Nakama T (1980) Hepatolithiasis in Japan. Am J Surg 139:216–219
Su CH, Lui WY, P’Eng FK (1992) Relative prevalence of gallstone diseases in Taiwan. A nation-wide cooperative study. Dig Dis Sci 37:764–768
Kwon OJ, PY, Kim JP (1982) A clinical study of cholelithiasis in Korea. J Korea Surg Soc 24:1052–1057
Tanimura H, Uchiyama K (1998) Epidemiological status of hepatolithiasis. J Biliary Tract Pancreas 19:5
Nakayama (1997) The survey of hepatolithiasis. Cause and treatment. Tokyo, New York, Igaku-Shoin Ltd, p 12
Tazuma S (2006) Gallstone disease: epidemiology, pathogenesis, and classification of biliary stones (common bile duct and intrahepatic). Best Pract Res Clin Gastroenterol 20:1075–1083
Tabata M, Nakayama F (1984) Bacteriology of hepatolithiasis. Prog Clin Biol Res 152:163–174
Leung JW, Sung JY, Costerton JW (1989) Bacteriological and electron microscopy examination of brown pigment stones. J Clin Microbiol 27:915–921
Zen Y, Harada K, Sasaki M (2002) Lipopolysaccharide induces overexpression of MUC2 and MUC5AC in cultured biliary epithelial cells: possible key phenomenon of hepatolithiasis. Am J Pathol 161:1475–1484
Kim HJ, Lee SK, Kim MH (2002) Cystic fibrosis transmembrane conductance regulators (CFTR) in biliary epithelium of patients with hepatolithiasis. Dig Dis Sci 47:1758–1765
Matsushiro T, Suzuki N, Sato T, Maki T (1977) Effects of diet on glucaric acid concentration in bile and the formation of calcium bilirubinate gallstones. Gastroenterology 72(4) Pt 1):630–633
Kamiya J, Nimura Y (2007) Intrahepatic Stones. Surgery of the Liver, Biliary Tract and Pancreas, Saunders Elsevier, Philadelphia (USA). Vol 1:586–596
Cook J, How Pc, Ho HC, Mcfadzean AJ (1954) Recurrent pyogenic cholangeitis. Br J Surg 42:188–203
Chou ST, Chan CW (1980) Recurrent pyogenic cholangitis: a necropsy study. Pathology 12(3):415–428
Tsunoda T, Tsuchiya R, Harada N et al (1985) Long-term results of surgical treatment for intrahepatic stones. Jpn J Surg 15:455–462
Nimura Y, MM, Yamada T et al (2001) Annual reports of the Japanese Ministry of Health and Welfare. Tokyo, Japan, p 6
Gupta AK, Gupta A, Bhardwa VK, Chansoria M (2006) Caroli’s disease. Indian J Pediatr 73:233–235
Khuroo MS, Zargar SA, Mahajan R (1990) Hepatobiliary and pancreatic ascariasis in India. Lancet 335:1503–1506
Rana SS, Bhasin DK, Nanda M, Singh K (2007) Parasitic infestations of the biliary tract. Curr Gastroenterol Rep 9:156–164
Dodd GD 3rd, Niedzwiecki GA, Campbell WL, Baron RL (1997) Bile duct calculi in patients with primary sclerosing cholangitis. Radiology 203:443–447
Rosmorduc O, Hermelin B, Boelle P-Y et al (2004) ABCB4 Gene Mutations and Primary Sclerosing Cholangitis. Gastroenterology 126:1220–1222
Chijiiwa K, Ichimya H, Kuroki S et al (1993) Late development of cholangiocarcinoma after the treatment of hepatolithiasis. Surg Gynecol Obstet 177:279–282
Holzinger F, Z’Graggen K, Buchler MW (1999) Mechanisms of biliary carcinogenesis: a pathogenetic multi-stage cascade towards cholangiocarcinoma. Ann Oncol 10(Suppl 4):122–126
Kuroki T, Tajima Y, Kanematsu T (2005) Hepatolithiasis and intrahepatic cholangiocarcinoma: carcinogenesis based on molecular mechanisms. J Hepatobiliary pancreat Surg 12:463–436
Ishikawa A, Sasaki M, Sato Y et al (2004) Frequent p 16ink4a inactivation is an early and frequent event of intraductal papillary neoplasm of the liver arising in hepatolithiasis. Hum Pathol 35:1505–1514
Kim YT, Byun JS, Kim J et al (2003) Factors predicting concurrent cholangiocarcinomas associated with hepatolithiasis. Hepatogastroenterology 50:8–12
Chijiiwa K, Ohtani K, Noshiro H et al (2002) Cholangiocellular carcinoma depending on the kind of intrahepatic calculi in patients with hepatolithiasis. Hepatogastroenterology 49:96–99
Lim JH (1991) Oriental cholangiohepatitis: pathologic, clinical, and radiologic features. AJR Am J Roentgenol 157:1–8
Kim TK, Kim BS, Kim JH et al (2002) Diagnosis of intrahepatic stones: superiority of MR cholangiopancreatography over endoscopic retrograde cholangio pancreatography. AJR Am J Roentgenol 179:429–434
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Ruzzenente, A., Zugni, C., Guglielmi, A. (2008). Clinical Pictures of Intrahepatic Lithiasis. In: Biliary Lithiasis. Springer, Milano. https://doi.org/10.1007/978-88-470-0763-5_38
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DOI: https://doi.org/10.1007/978-88-470-0763-5_38
Publisher Name: Springer, Milano
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