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HCV-Associated Membranoproliferative Glomerulonephritis

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HCV Infection and Cryoglobulinemia

Abstract

Hepatitis C virus (HCV) is a blood-borne and sexually transmitted single-stranded RNA flavivirus that causes a broad spectrum of liver disease, ranging from acute to chronic hepatitis, cirrhosis, and hepatocellular carcinoma. The worldwide prevalence of HCV positivity is highly variable. Hepatitis C infection is associated with a wide variety of renal diseases but the most common pattern of renal injury is Membranoproliferative glomerulonephritis (>50% of cases). This chapter reviews the epidemiology, pathogenesis, clinical and laboratory manifestations, pathology, and differential diagnosis of HCV-associated cryoglobulinemic. Therapeutic approaches to the management of patients with nephritic, nephritic, and vasculitic manifestations are also briefly considered.

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Authors and Affiliations

  1. Renal and Electrolyte Division, Department of Internal Medicine, University of Pittsburgh, Pittsburgh, PA, USA

    Christos P. Argyropoulos & John Prentiss Johnson

  2. Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA

    Sheldon Bastacky

Authors
  1. Christos P. Argyropoulos
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  2. Sheldon Bastacky
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  3. John Prentiss Johnson
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Corresponding author

Correspondence to Christos P. Argyropoulos .

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Editors and Affiliations

  1. , Department of Internal Medicine and Clin, University of Bari, Piazza Giulio Cesare 11, Bari, 70124, Italy

    Franco Dammacco

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Argyropoulos, C.P., Bastacky, S., Johnson, J.P. (2012). HCV-Associated Membranoproliferative Glomerulonephritis. In: Dammacco, F. (eds) HCV Infection and Cryoglobulinemia. Springer, Milano. https://doi.org/10.1007/978-88-470-1705-4_22

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  • DOI: https://doi.org/10.1007/978-88-470-1705-4_22

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  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-1704-7

  • Online ISBN: 978-88-470-1705-4

  • eBook Packages: MedicineMedicine (R0)

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