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Epidemiology and Comprehensive Management of HIV-Related Diarrhea in Africa

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Textbook-Atlas of Intestinal Infections in AIDS
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Abstract

Acquired immune deficiency syndrome (AIDS) was first identified in Africa as slim disease, partly because of the associated chronic diarrhea [1, 2]. This is still true in developing countries, especially in sub-Saharan Africa, where chronic diarrhea last- ing more than 1 month remains an important clini- cal presentation despite the advent of effective anti- retroviral drugs. Chronic diarrhea is associated with significant morbidity and mortality rates, particu- larly in areas where both financial and human resources are limited in providing adequate care. In this case, effective management calls for a strategic approach involving both conventional and uncon- ventional principles.

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References

  1. Serwadda D, Mugerwa R, Sewankambo N, et al(1985) Slim disease; a new disease in Uganda and its associ-ation with HTLV III Infection. Lancet 2:849–852

    Article  PubMed  CAS  Google Scholar 

  2. Mhiri C, Belec L, Di Costanzo B, Georges A, Gherardi R (1992) The slim disease in African patients with AIDS. Trans R Soc Trop Med Hyg 86:303–306

    Article  PubMed  CAS  Google Scholar 

  3. Colebunders R, Francis H, Mann JM, et al(1987) Per-sistent diarrhea, strongly associated with HIV infec-tion in Kinshasa, Zaire. Am J Gastr Entorol 82:859–864

    CAS  Google Scholar 

  4. O’Keefe EA, Wood R (1996) AIDS in Africa. Scand J Gastroenterol 220 [Suppl]:147–152

    Article  Google Scholar 

  5. Kelly P, Baboo KS, Wolff M, Ngwenya B, Luo N, Far-thing MJ (1996) The prevalence and etiology of per-sistent diarrhea in adults in urban Zambia. Acta Trop 61:183–190

    Article  PubMed  CAS  Google Scholar 

  6. Thea DM, Glass R, Grohmann GS, et al(1993) Preva-lence of enteric viruses among hospital patients with AIDS in Kinshasa, Zaire. Trans R Soc Trop Med Hyg 87:263–266

    Article  PubMed  CAS  Google Scholar 

  7. Colebunders RL, Latif AS (1991) Natural history and clinical presentation of HIV-i infection in adults. AIDS 5[Suppl 1]:S103–S112

    PubMed  Google Scholar 

  8. Mugerwa RD, Marum LH, Serwadda D (1996) Human immunodeficiency virus and AIDS in Uganda. E African Med J 73:20–25

    CAS  Google Scholar 

  9. Sewankambo NK, Mugerwa RD, Goodgame R, et al (1987) Enteropathie AIDS in Uganda. An endoscopic, histological and microbiological study. AIDS 1:9–13

    PubMed  CAS  Google Scholar 

  10. Colebunders R, Lusakumunu K, Nelson AM, et al (1988) Persistent diarrhea in Zairian AIDS patients: an endoscopic and histological study. Gut 29:1687–1691

    Article  PubMed  CAS  Google Scholar 

  11. Conlon CP, Pinching AJ, Perera CU, Moody A, Luo NP, Lucas SB (1990) HIV-related enteropathy in Lusaka, Zambia: a clinical, microbiological and histo-logical study. Am J Trop Med Hyg 42:83–88

    PubMed  CAS  Google Scholar 

  12. Lucas SB, Papadaki L, Conlon C, Sewankambo N, Goodgame R, Serwadda D (1989) Diagnosis of intes-tinal microsporidiosis in patients with AIDS. J Clin Pathol 42:885–887

    Article  PubMed  CAS  Google Scholar 

  13. Katabira E, Goodgame R (1989) AIDS Care: Diagnos-tic and treatment strategies for health workers. Entebbe, Uganda. AIDS Control Programme, Min-istry of Health

    Google Scholar 

  14. Katabira ET, Wabitsch RK (1991) Management issues for patients with HIV infection in Africa. AIDS 5 [Suppl]:S149–S155

    PubMed  Google Scholar 

  15. USPHS/IDSA Prevention of Opportunistic Infections Working Group (1997) 1997 USPHS/IDSA guidelines for the prevention of opportunistic infections in per-sons infected with human immune deficiency virus: Disease-specific recommendations. Clin Infect Dis 25 [Suppl3]:S313

    Google Scholar 

  16. Anglaret X, Chene G, Attia A, et al(1999) Early chemoprophylaxis with trimethoprim-sulfamethaxa-zole in HIV-i infected adults in Abdjan, Cote d’lvoire: a randomized trial. Lancet 353:1463–1468

    Article  PubMed  CAS  Google Scholar 

  17. Bini EJ, Cohen J (1998) Effect of protease inhibitors on the outcome of chronic HIV-related diarrhea. Gas-troenterology H4:A933

    Article  Google Scholar 

  18. WHO (2002) Scaling up antiretroviral therapy in resource-limited settings. WHO, Geneva

    Google Scholar 

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© 2003 Springer-Verlag Italia

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Katabira, E.T. (2003). Epidemiology and Comprehensive Management of HIV-Related Diarrhea in Africa. In: Dionisio, D. (eds) Textbook-Atlas of Intestinal Infections in AIDS. Springer, Milano. https://doi.org/10.1007/978-88-470-2091-7_29

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  • DOI: https://doi.org/10.1007/978-88-470-2091-7_29

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-2166-2

  • Online ISBN: 978-88-470-2091-7

  • eBook Packages: Springer Book Archive

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