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Diffusion-Weighted Imaging of the Normal-Appearing White Matter in Multiple Sclerosis

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Normal-appearing White and Grey Matter Damage in Multiple Sclerosis

Part of the book series: Topics in Neuroscience ((TOPNEURO))

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Abstract

Conventional magnetic resonance (MR) imaging (MRI) is widely used for the diagnosis of multiple sclerosis (MS), because of its ability to demonstrate the presence of central nervous system (CNS) lesions with dissemination in space and time [1]. In addition, when monitoring the evolution of MS, serial brain MRI scans may disclose the occurrence of disease activity and the accumulation of disease burden with a greater sensitivity than the clinical assessment of relapses and neurological disability. Nevertheless, since a clear discrepancy between clinical and conventional MRI findings in patients with established MS has emerged from most of the available studies [2], there is an urgent need for more accurate neuroimaging techniques to monitor MS evolution.

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References

  1. McDonald WI, Compston A, Edan G et al (2001) Recommended diagnostic criteria for multiple sclerosis: guidelines from the international panel on the diagnosis of multiple sclerosis. Ann Neurol 50:121–127

    Article  PubMed  CAS  Google Scholar 

  2. Filippi M, Grossman RI (2002) MRI techniques to monitor MS evolution: the present and the future. Neurology 58:1147–1153

    Article  PubMed  Google Scholar 

  3. Allen IV, McKeown SR (1979) A histological, histochemical and biochemical study of the macroscopically normal white matter in multiple sclerosis. J Neurol Sci 41:81–91

    Article  PubMed  CAS  Google Scholar 

  4. Evangelou N, Esiri MM, Smith S et al (2000) Quantitative pathological evidence for axonal loss in normal appearing white matter in multiple sclerosis. Ann Neurol 47:391–395

    Article  PubMed  CAS  Google Scholar 

  5. Evangelou N, Konz D, Esiri MM et al (2000) Regional axonal loss in the corpus callo-sum correlates with cerebral white matter lesion volume and distribution in multiple sclerosis. Brain 123:1845–1849

    Article  PubMed  Google Scholar 

  6. Filippi M, Tortorella C, Bozzali M (1999) Normal-appearing-white-matter changes in multiple sclerosis: the contribution of magnetic resonance techniques. Mult Scler 5:273–282

    PubMed  CAS  Google Scholar 

  7. Le Bihan D, Breton E, Lallemand D et al (1986) MR imaging of intravoxel incoherent motions: application to diffusion and perfusion in neurologic disorders. Radiology 161:401–407

    PubMed  Google Scholar 

  8. Le Bihan D, Turner R, Pekar J, Moonen CTW (1991) Diffusion and perfusion imaging by gradient sensitization: design, strategy and significance. J Magn Reson Imaging 1:7–8

    Article  PubMed  Google Scholar 

  9. Basser PJ, Mattiello J, Le Bihan D (1994) Estimation of the effective self-diffusion tensor from the NMR spin-echo. J Magn Reson B 103:247–254

    Article  PubMed  CAS  Google Scholar 

  10. Pierpaoli C, Jezzard P, Basser PI et al (1996) Diffusion tensor MR imaging of the human brain. Radiology 201:637–648

    PubMed  CAS  Google Scholar 

  11. Basser PJ, Pierpaoli C (1996) Microstructural features measured using diffusion tensor imaging. J Magn Reson B 111:209–219

    Article  PubMed  CAS  Google Scholar 

  12. Cercignani M, Bozzali M, Iannucci G et al (2002) Intra-voxel and inter-voxel coherence in patients with multiple sclerosis assessed using diffusion tensor MRI. J Neurol 249:875–883

    Article  PubMed  CAS  Google Scholar 

  13. Cercignani M, Bammer R, Sormani MP et al (2003) Inter-sequence and inter-imaging unit variability of diffusion tensor MR imaging histogram-derived metrics of the brain in healthy volunteers. AJNR Am J Neuroradiol 24:638–643

    PubMed  Google Scholar 

  14. Cercignani M, Bozzali M, Iannucci G et al (2001) Magnetisation transfer ratio and mean diffusivity of normal appearing white and grey matter from patients with mul- tiple sclerosis. J Neurol Neurosurg Psychiatry 70:311–317

    Article  PubMed  CAS  Google Scholar 

  15. Cercignani M, Inglese M, Siger-Zajdel M, Filippi M (2001) Segmenting white matter, grey matter and cerebro-spinal fluid using diffusion tensor MRI-derived indices. Magn Reson Imaging 19:1167–1172

    Article  PubMed  CAS  Google Scholar 

  16. Larsson HBW, Thomsen C, Frederiksen J et al (1992) In vivo magnetic resonance diffusion measurement in the brain of patients with multiple sclerosis. Magn Reson Imaging 10:7–12

    Article  PubMed  CAS  Google Scholar 

  17. Christiansen P, Gideon P, Thomsen C et al (1993) Increased water self-diffusion in chronic plaques and in apparently normal white matter in patients with multiple sclerosis. Acta Neurol Scand 87:195–199

    Article  PubMed  CAS  Google Scholar 

  18. Horsfield MA, Lai M, Webb SL et al (1996) Apparent diffusion coefficients in benign and secondary progressive multiple sclerosis by nuclear magnetic resonance. Magn Reson Med 36:393–400

    Article  PubMed  CAS  Google Scholar 

  19. Droogan AG, Clark CA, Werring DJ et al (1999) Comparison of multiple sclerosis clinical subgroups using navigated spin echo diffusion-weighted imaging. Magn Reson Imaging 17:653–661

    Article  PubMed  CAS  Google Scholar 

  20. Werring DJ, Clark CA, Barker GJ et al (1999) Diffusion tensor imaging of lesions and normal-appearing white matter in multiple sclerosis. Neurology 52:1626–1632

    Article  PubMed  CAS  Google Scholar 

  21. Filippi M, Iannucci G, Cercignani M et al (2000) A quantitative study of water diffusion in multiple sclerosis lesions and normal-appearing white matter using echo-planar imaging. Arch Neurol 57:1017–1021

    Article  PubMed  CAS  Google Scholar 

  22. Cercignani M, Iannucci G, Rocca MA et al (2000) Pathologic damage in MS assessed by diffusion-weighted and magnetization transfer MRI. Neurology 54:1139–1144

    Article  PubMed  CAS  Google Scholar 

  23. Rocca MA, Cercignani M, Iannucci G et al (2000) Weekly diffusion-weighted imaging of normal-appearing white matter in MS. Neurology 55:882–884

    Article  PubMed  CAS  Google Scholar 

  24. Werring DJ, Brassat D, Droogan AG et al (2000) The pathogenesis of lesions and normal-appearing white matter changes in multiple sclerosis. A serial diffusion MRI study. Brain 123:1667–1676

    Google Scholar 

  25. Bammer R, Augustin M, Strasser-Fuchs S et al (2000) Magnetic resonance diffusion tensor imaging for characterizing diffuse and focal white matter abnormalities in multiple sclerosis. Magn Reson Med 44:583–59

    Article  PubMed  CAS  Google Scholar 

  26. Nusbaum AO, Lu D, Tang CY, Atlas SW (2000) Quantitative diffusion measurements in focal multiple sclerosis lesions: correlations with appearance on Tl-weighted MR images. AJR Am J Roentgenol 175:821–825

    PubMed  CAS  Google Scholar 

  27. Roychowdhury S, Maldijan JA, Grossman RI (2000) Multiple sclerosis: comparison of trace apparent diffusion coefficients with MR enhancement pattern of lesions. AJNR Am J Neuroradiol 21:869–874

    PubMed  CAS  Google Scholar 

  28. Filippi M, Cercignani M, Inglese M et al (2001) Diffusion tensor magnetic resonance imaging in multiple sclerosis. Neurology 56:304–311

    Article  PubMed  CAS  Google Scholar 

  29. Ciccarelli O, Werring DJ, Wheeler-Kingshott CA et al (2001) Investigation of MS normal-appearing brain using diffusion tensor MRI with clinical correlations. Neurology 56:926–933

    Article  PubMed  CAS  Google Scholar 

  30. Werring DJ, Clark CA, Droogan AG et al (2001) Water diffusion is elevated in widespread regions of normal-appearing white matter in multiple sclerosis and correlates with diffusion in focal lesions. Mult Scler 7:83–89

    PubMed  CAS  Google Scholar 

  31. Ciccarelli O, Werring DJ, Barker GJ et al (2003) A study of the mechanisms of normalappearing white matter damage in multiple sclerosis using diffusion tensor imaging. Evidence of Wallerian degeneration. J Neurol 250:287–292

    Article  PubMed  Google Scholar 

  32. Griffin CM, Chard DT, Ciccarelli O et al (2001) Diffusion tensor imaging in early relapsing-remitting multiple sclerosis. Mult Scler 7:290–297

    PubMed  CAS  Google Scholar 

  33. Caramia F, Pantano P, Di Legge S et al (2002) A longitudinal study of MR diffusion changes in normal appearing white matter of patients with early multiple sclerosis. Magn Reson Imaging 20:383–388

    Article  PubMed  Google Scholar 

  34. Guo AC, Jewells VL, Provenzale JM (2001) Analysis of normal-appearing white matter in multiple sclerosis: comparison of diffusion tensor MR imaging and magnetization transfer imaging. AJNR Am J Neuroradiol 22:1893–1900

    PubMed  CAS  Google Scholar 

  35. Guo AC, MacFall JR, Provenzale JM (2002) Multiple sclerosis: diffusion tensor MR imaging for evaluation of normal-appearing white matter. Radiology 222:729–736

    Article  PubMed  Google Scholar 

  36. Thompson AJ, Polman CH, Miller DH et al (1997) Primary progressive multiple sclerosis. Brain 120:1085–1096

    Article  PubMed  Google Scholar 

  37. Rovaris M, Bozzali M, Iannucci G et al (2002) Assessment of normal-appearing white and grey matter in patients with primary progressive multiple sclerosis. Arch Neurol 59:1406–1412

    Article  PubMed  Google Scholar 

  38. Mezzapesa DM, Rocca MA, Falini A et al (2004) A preliminary diffusion tensor and magnetization transfer MRI study of early-onset MS. Arch Neurol 61:366–368

    Article  PubMed  Google Scholar 

  39. Rocca MA, Pagani E, Ghezzi A et al (2003) Functional cortical changes in patients with multiple sclerosis and nonspecific findings on conventional magnetic resonance imaging scans of the brain. Neuroimage 19:826–836

    Article  PubMed  Google Scholar 

  40. Inglese M, Salvi F, Iannucci G et al (2002) Magnetization transfer and diffusion tensor MR imaging of acute disseminated encephalomyelitis. AJNR Am J Neuroradiol 23:267–272

    PubMed  Google Scholar 

  41. Cercignani M, Inglese M, Pagani E et al (2001) Mean diffusivity and fractional anisotropy histograms in patients with multiple sclerosis. AJNR Am J Neuroradiol 22:952–958

    PubMed  CAS  Google Scholar 

  42. Iannucci G, Rovaris M, Giacomotti L et al (2001) Correlations between measures of multiple sclerosis pathology derived from T2, Tl, magnetization transfer and diffusion tensor MR imaging. AJNR Am J Neuroradiol 22:1462–1467

    PubMed  CAS  Google Scholar 

  43. Oreja-Guevara C, Rovaris M, Caputo D et al (2003) Short-term evolution of brain tissue damage in untreated relapsing-remitting multiple sclerosis patients: an in vivo study using diffusion tensor MRI [abstract]. Mult Scler 9(Suppl 1):S59

    Google Scholar 

  44. Rovaris M, Gallo A, Caputo D et al (2003) Short-term evolution of brain tissue damage in patients with primary progressive multiple sclerosis:an in vivo study using diffusion tensor MRI [abstract]. Mult Scler 9(Suppl 1):S60

    Google Scholar 

  45. Kurtzke JF (1983) Rating neurological impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology 33:1444–1452

    Article  PubMed  CAS  Google Scholar 

  46. Rovaris M, Iannucci G, Falautano M et al (2002) Cognitive dysfunction in patients with mildly disabling relapsing-remitting multiple sclerosis: an exploratory study with diffusion tensor MR imaging. J Neurol Sci 195:103–109

    Article  PubMed  Google Scholar 

  47. Conturo TE, Lori NF, Cull TS et al (1999) Tracking neuronal fiber pathways in the living human brain. Proc Natl Acad Sci U S A 96:10422–10427

    Article  PubMed  CAS  Google Scholar 

  48. Mori S, Crain BJ, Chacko VP, van Zijl PC (1999) Three-dimensional tracking of axonal projections in the brain by magnetic resonance imaging. Ann Neurol 45:265–269

    Article  PubMed  CAS  Google Scholar 

  49. Mori S, Kaufmann WE, Davatzikos C et al (2002) Imaging cortical association tracts in the human brain using diffusion-tensor-based axonal tracking. Magn Reson Med 47:215–223

    Article  PubMed  Google Scholar 

  50. Tench CR, Morgan PS, Wilson M, Blumhardt LD (2002) White matter mapping using diffusion tensor MRI. Magn Reson Med 47:967–972

    Article  PubMed  CAS  Google Scholar 

  51. Wilson M, Tench CR, Morgan PS, Blumhardt LD (2003) Pyramidal tract mapping by diffusion tensor magnetic resonance imaging in multiple sclerosis: improving correlations with disability. J Neurol Neurosurg Psychiatry 74:203–207

    Article  PubMed  CAS  Google Scholar 

  52. Vaithianathar L, Tench CR, Morgan PS et al (2002) Tl relaxation time mapping of white matter tracts in multiple sclerosis defined by diffusion tensor imaging. J Neurol 249:1272–1278

    Article  PubMed  Google Scholar 

  53. Assaf Y, Ben-Bashat D, Chapman J et al (2002) High b-value q-space analyzed diffusion-weighted MRI: application to multiple sclerosis. Magn Reson Med 47:115–126

    Article  PubMed  CAS  Google Scholar 

  54. Assaf Y, Cohen Y (2000) Assignment of the water slow-diffusing component in the central nervous system using q-space diffusion MRS: implications for fiber tract imaging. Magn Reson Med 43:191–199

    Article  PubMed  CAS  Google Scholar 

  55. Clark CA, Werring DJ (2002) Diffusion tensor imaging in spinal cord: methods and applications - a review. NMR Biomed 15:578–586

    Article  PubMed  Google Scholar 

  56. Iwasawa T, Matoba H, Ogi A et al (1997) Diffusion-weighted imaging of the human optic nerve: a new approach to evaluate optic neuritis in multiple sclerosis. Magn Reson Med 38:484–491

    Article  PubMed  CAS  Google Scholar 

  57. Wheeler-Kingshott CA, Parker GJM, Symms MR et al (2002) ADC mapping of the human optic nerve: increased resolution, coverage, and reliability with CSF-supressed ZOOM-EPI. Magn Reson Med 47:24–31

    Article  PubMed  Google Scholar 

  58. Clark CA, Werring DJ, Miller DH (2000) Diffusion imaging of the spinal cord in vivo: estimation of the principal diffusivities and application to multiple sclerosis. Magn Reson Med 43:133–138

    Article  PubMed  CAS  Google Scholar 

  59. Ries M, Jones RA, Dousset V, Moonen CTW (2000) Diffusion tensor MRI of the spinal cord. Magn Reson Med 44:884–892

    Article  PubMed  CAS  Google Scholar 

  60. Bammer R, Fazekas F, Augustin M et al (2000) Diffusion-weighted MR imaging of the spinal cord. AJNR Am J Neuroradiol 21:587–591

    PubMed  CAS  Google Scholar 

  61. Robertson RL, Maier SE, Mulkern RV et al (2000) MR line-scan diffusion imaging of the spinal cord in children. AJNR Am J Neuroradiol 21:1344–1348

    PubMed  CAS  Google Scholar 

  62. Wheeler-Kingshott CA, Hickman SJ, Parker GJ et al (2002) Investigating cervical spinal cord structure using axial diffusion tensor imaging. Neuroimage 16:93–102

    Article  PubMed  Google Scholar 

  63. Bammer R, Augustin M, Prokesch RW et al (2002) Diffusion-weighted imaging of the spinal cord: interleaved echo-planar imaging is superior to fast spin-echo. J Magn Reson Imaging 15:364–373

    Article  PubMed  Google Scholar 

  64. Cercignani M, Horsfield MA, Agosta F, Filippi M (2003) Sensitivity-encoded diffusion tensor MR imaging of the cervical cord. AJNR Am J Neuroradiol 24:1254–1256

    PubMed  Google Scholar 

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Authors
  1. M. Rovaris
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  2. M. Filippi
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Editors and Affiliations

  1. Department of Neurology Scientific Institute, University Ospedale San Raffaele, Milan, Italy

    Giancarlo Comi

  2. Neuroimaging Research Unit Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Milan, Italy

    Massimo Filippi  & Marco Rovaris  & 

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Rovaris, M., Filippi, M. (2004). Diffusion-Weighted Imaging of the Normal-Appearing White Matter in Multiple Sclerosis. In: Comi, G., Filippi, M., Rovaris, M. (eds) Normal-appearing White and Grey Matter Damage in Multiple Sclerosis. Topics in Neuroscience. Springer, Milano. https://doi.org/10.1007/978-88-470-2127-3_7

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  • DOI: https://doi.org/10.1007/978-88-470-2127-3_7

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-2175-4

  • Online ISBN: 978-88-470-2127-3

  • eBook Packages: Springer Book Archive

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