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Mediators in Bronchial Provocation Tests

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Methods in Asthmology

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Abstract

Three major pathogenetic components characterize bronchial asthma: (1) atopy, i.e., increased levels of IgE and increased degranulation of mast cells and basophils triggered by IgE-mediated or non-IgE-mediated stimuli; (2) allergic inflammation, which damages to varying extents the bronchial wall components (epithelium, vessels, submucosal glands, respiratory nerve endings, and smooth muscle); (3) bronchial hyperreactivity (BH) to physical, chemical, and allergic stimuli, which trigger bronchial obstruction by bronchospasm, vasodilation, mucosal edema, and mucous hypersecretion.

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  1. Centro per lo Studio dell‘ Asma e delle Allergopatie Respiratorie, Pisa, Italy

    N. Del Bono & L. Del Bono

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  1. N. Del Bono
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  1. Istituto di Malattie Respiratorie, Policlinico — Pad. Litta, Via F. Sforza, 35, Milano, 20100, Italy

    Luigi Allegra M.D.

  2. Centro di Farmacologia Respiratoria, Via Vanvitelli, 32, Milano, 20129, Italy

    Pier Carlo Braga M.D.

  3. Servizio di Fisiopatologia Respiratoria, Ospedale di Bussolengo, Via Ospedale, 2, Bussolengo (Verona), 37012, Italy

    Roberto Dal Negro M.D.

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Del Bono, N., Del Bono, L. (1993). Mediators in Bronchial Provocation Tests. In: Allegra, L., Braga, P.C., Dal Negro, R. (eds) Methods in Asthmology. Springer, Milano. https://doi.org/10.1007/978-88-470-2263-8_18

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  • DOI: https://doi.org/10.1007/978-88-470-2263-8_18

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