Abstract
Postinfectious neurologic syndromes (PINSs) of the central nervous system (CNS) include monophasic, sometimes relapsing (20–30 % of patients) disorders, triggered by an antigenic challenge, such as a systemic infection or a vaccination.
CNS involvement may be “disseminated” in the classic acute disseminated encephalomyelitis (ADEM), or site-restricted, in isolated encephalitis and myelitis.
Predictors of poor prognosis in PINSs are: (1) older age, (2) severity of neurological dysfunction at onset, (3) higher CSF albumin, (4) absence of fever at onset, (5) spinal cord involvement, and (6) peripheral involvement.
Considering all variants, residual motor disability is found in 50 % of cases. Mortality rate is less than 5 %.
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Marchioni, E., Ravaglia, S. (2015). Myelin Disorders: Postinfectious Neurological Syndromes. In: Sghirlanzoni, A., Lauria, G., Chiapparini, L. (eds) Prognosis of Neurological Diseases. Springer, Milano. https://doi.org/10.1007/978-88-470-5755-5_13
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DOI: https://doi.org/10.1007/978-88-470-5755-5_13
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