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Antimicrobiële eiwitten in speeksel

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Speeksel en speekselklieren

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Samenvatting

Speeksel bevat verschillende eiwitten en peptiden met antimicrobiële eigenschappen. In kwantitatief opzicht de belangrijkste zijn:

Daarnaast bevat speeksel ook bacteriebindende eiwitten, onder andere immuunglobulinen, die hun kolonisatie in de mond remmen.

  • Lysozym: breekt mureïne in de celwand af en verstoort het membraan van grampositieve bacteriën. Hierdoor lyseert de bacterie en sterft af.

  • Lactoperoxidase (uit speekselklieren) en myeloperoxidase (uit leukocyten): katalyseren de vorming van de antimicrobiële verbinding OSCN− uit SCN− met behulp van waterstofperoxide. OSCN− inactiveert essentiële enzymen in de cel.

  • Lactoferrine: bindt ijzerionen die bacteriën nodig hebben voor groei. Bij proteolytische afbraak van van lactoferrine in de maag worden peptiden vrijgemaakt met bacteriedodende werking.

  • Chitinase: hydrolyseert bindingen in chitine, een onderdeel van de celwand van schimmels.

  • SLPI is een antibacterieel eiwit dat in lage concentraties in speeksel voorkomt.

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Literatuur

  • Campo J, Perea MA, del Romero J, Cano J, Hernando V, Bascones A. Oral transmission of HIV, reality or fiction? An update. Oral Dis. 2006;12:219–28.

    Article  PubMed  Google Scholar 

  • Carpenter GH. The secretion, components, and properties of saliva. Ann Rev Food Sci Technol. 2013;4:267–76.

    Article  Google Scholar 

  • Fabian TK, Hermann P, Beck A, Fejerdy P, Fabian G. Salivary defense proteins: Their network and role in innate and acquired oral immunity. Int J Mol Sci. 2012;13:4295–320.

    Article  PubMed Central  PubMed  Google Scholar 

  • Ganeshnarayan K, Velliyagounder K, Furgang D, Fine DH. Human salivary cystatin SA exhibits antimicrobial effect against Aggregatibacter actinomycetemcomitans. J Period Res. 2012;47:661–73.

    Article  Google Scholar 

  • McBride J, Walker LR, Grange PA, Dupin N, Akula SM. Molecular biology of lactoferrin and its role in modulating immunity and viral pathogenesis. Future Virol. 2013;8:289–99.

    Article  Google Scholar 

  • Nieuw Amerongen A van, Veerman ECI. Saliva – the defender of the oral cavity. Oral Dis. 2002;8:12–22.

    Article  Google Scholar 

  • Scott A, Weldon S, Taggart CC. SLPI and elafin: multifunctional antiproteases of the WFDC family. Biochem Soc Trans. 2011;39:1437–40.

    Article  PubMed  Google Scholar 

  • Steijn GJ van, Amerongen AV, Veerman ECI, Kasanmoentalib S, Overdijk B. Effect of periodontal treatment on the activity of chitinase in whole saliva of periodontitis patients. J Period Res. 2002;37:245–9.

    Article  Google Scholar 

  • Wilkinson TS, Roghanian A, Simpson, Sallenave JM. WAP domain proteins as modulators of mucosal immunity. Biochem Soc Trans. 2011;39:1409–15.

    Article  PubMed  Google Scholar 

  • Weinberg ED. Antibiotic properties and applications of lactoferrin. Curr Pharm Des. 2007;13:801–81.

    Article  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Sectie Orale Biochemie, Academisch Centrum Tandheelkunde Amsterdam, Amsterdam, The Netherlands

    W. van ’t Hof & E.C.I. Veerman

Authors
  1. W. van ’t Hof
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  2. E.C.I. Veerman
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Editor information

Editors and Affiliations

  1. Amsterdam, Noord-Holland, The Netherlands

    E.C.I. Veerman

  2. Groningen, The Netherlands

    A. Vissink

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© 2014 Bohn Stafleu van Loghum

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van ’t Hof, W., Veerman, E. (2014). Antimicrobiële eiwitten in speeksel. In: Veerman, E., Vissink, A. (eds) Speeksel en speekselklieren. Bohn Stafleu van Loghum, Houten. https://doi.org/10.1007/978-90-368-0387-8_5

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  • DOI: https://doi.org/10.1007/978-90-368-0387-8_5

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  • Publisher Name: Bohn Stafleu van Loghum, Houten

  • Print ISBN: 978-90-368-0386-1

  • Online ISBN: 978-90-368-0387-8

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