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Anatomie van de gebruikte targets bij diepe hersenstimulatie

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Handboek diepe hersenstimulatie bij neurologische en psychiatrische aandoeningen

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Het doel van diepe hersenstimulatie (‘deep brain stimulation’, DBS) is het moduleren van de activiteit van specifieke anatomische gebieden in de hersenen en daarmee symptomen van neurologische of psychiatrische aandoeningen te verbeteren. Dit onderstreept de nauwe relatie tussen anatomie en functie. Anatomisch zijn de targets voor DBS voornamelijk gelegen in de basale kernen en de thalamus. Beide structuren zijn verbonden met hogere (corticale) en lagere (hersenstam) gebieden zowel door deels parallelle als deels geïntegreerde projecties. Deze projecties zijn verantwoordelijk voor motorische, associatieve en emotionele functies. Voor de bewegingsstoornissen zijn de meest relevante structuren het dorsolaterale deel van de nucleus subthalamicus, het posteroventrolaterale deel van de globus pallidus internus, en de ventrolaterale kernen van de thalamus. Voor de pyschiatrische ziektebeelden zijn de relevante targets het ventrale striatum, waaronder de nucleus accumbens, het ventrale deel van de capsula interna, het ventromediale deel van de nucleus subthalamicus, het anterieure deel van de globus pallidus internus, en de mediale kernen van de thalamus. Voor patiënten met epilepsie is de nucleus anterior van de thalamus, onderdeel van het circuit van Papez, van belang.

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Author information

Authors and Affiliations

  1. Afdeling Neurochirurgie, Maastricht UMC+, Maastricht, The Netherlands

    Yasin Temel & Birgit Plantinga

  2. Afdeling Neurologie, Maastricht UMC+, Maastricht, The Netherlands

    Mark Kuijf

Authors
  1. Yasin Temel
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  2. Birgit Plantinga
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  3. Mark Kuijf
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Editor information

Editors and Affiliations

  1. Maastricht University Medical Cente Department of Neurosurgery, Maastricht, The Netherlands

    Y. Temel

  2. Dept. Of Psychiatry, Maastricht Univeristy Medical Centre, Maastricht, The Netherlands

    A.F.G. Leentjens

  3. Afd. Neurologie, Amsterdam Medisch Centrum, Amsterdam, The Netherlands

    R.M.A. de Bie

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© 2016 Bohn Stafleu van Loghum

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Temel, Y., Plantinga, B., Kuijf, M. (2016). Anatomie van de gebruikte targets bij diepe hersenstimulatie. In: Temel, Y., Leentjens, A., de Bie, R. (eds) Handboek diepe hersenstimulatie bij neurologische en psychiatrische aandoeningen. Bohn Stafleu van Loghum, Houten. https://doi.org/10.1007/978-90-368-0959-7_2

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  • DOI: https://doi.org/10.1007/978-90-368-0959-7_2

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  • Publisher Name: Bohn Stafleu van Loghum, Houten

  • Print ISBN: 978-90-368-0958-0

  • Online ISBN: 978-90-368-0959-7

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