Skip to main content
SpringerLink
Log in

Regeneratie van pulpaweefsel

  • Chapter
  • First Online:
Het tandheelkundig jaar 2017

  • 301 Accesses

Samenvatting

De afgelopen vijftien jaar is er, met behulp van de ontwikkelingsbiologie en weefseltechnologie, een alternatieve therapie uitgewerkt voor het behandelen van geïnfecteerde, zeer immature, blijvende dentitie: de regeneratieve endodontische behandeling (REB). REB berust op vooral chemische desinfectie van het wortelkanaal en drie pijlers: stamcellen, groeifactoren en scaffolds. Het cell homing- en cell based-principe zijn de twee grote concepten van deze behandeling. Het cell based-principe berust op pulpaweefseltechnologie en -transplantatie en heeft tot nog toe vooral in vitro zijn toepassing. Het leidt tot gunstige resultaten voor weefselregeneratie. Vanwege ethische, financiële en infrastructurele beslommeringen, wordt klinisch eerder het cell homing-concept toegepast, wat leidt tot gunstige infectieheling, maar eerder herstel (dan regeneratie) van het pulpadentinecomplex. Omdat er langetermijnresultaten ontbreken en het evidentieniveau van REB nog laag is, is er behoefte aan klinisch, microbieel en translationeel onderzoek.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 89.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 119.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Notes

  1. 1.

    ICF-richtlijnen UZ Leuven ‘Formeel geven de kinderen zelf geen toestemming maar moeten wel schriftelijk kunnen instemmen met deelname aan het onderzoek (“instemming” of “assent”, aangeraden vanaf 12 jaar). Uiteraard moeten de ouders steeds hun akkoord geven (“toestemming” of “consent”) voor deelname van hun minderjarige kind aan een studie’ (https://www.uzleuven.be/toetsingscommissie/icf-richtlijnen-voor-het-opstellen-van-een-icf).

Literatuur

  • Althumairy RI, Teixeira FB, Diogenes A. Effect of dentin conditioning with intracanal medicaments on survival of stem cells of apical papilla. J Endod. 2014;40(4):521–5.

    Article  PubMed  Google Scholar 

  • Bakland LK, Andreasen JO. Will mineral trioxide aggregate replace calcium hydroxide in treating pulpal and periodontal healing complications subsequent to dental trauma? A review. Dent Traumatol. 2012;28(1):25–32.

    Article  PubMed  Google Scholar 

  • Bezgin T, Sonmez H. Review of current concepts of revascularization/revitalization. Dent Traumatol. 2015;31(4):267–73.

    Article  PubMed  Google Scholar 

  • Bezgin T, Yilmaz AD, Celik BN, Kolsuz ME, Sonmez H. Efficacy of platelet-rich plasma as a scaffold in regenerative endodontic treatment. J Endod. 2015;41(1):36–44.

    Article  PubMed  Google Scholar 

  • Bose R, Nummikoski P, Hargreaves K. A retrospective evaluation of radiographic outcomes in immature teeth with necrotic root canal systems treated with regenerative endodontic procedures. J Endod. 2009;35(10):1343–9.

    Article  PubMed  Google Scholar 

  • Chrepa V, Henry MA, Daniel BJ, Diogenes A. Delivery of apical mesenchymal stem cells into root canals of mature teeth. J Dent Res. 2015;94(12):1653–9. [E-pub ahead of print.]

    Google Scholar 

  • Cvek M. Prognosis of luxated non-vital maxillary incisors treated with calcium hydroxide and filled with gutta-percha: a retrospective clinical study. Endod Dent Traumatol. 1992;8(2):45–55.

    Article  PubMed  Google Scholar 

  • Diogenes A, Henry MA, Teixeira FB. An update on clinical regenerative endodontics. Endod Top. 2013;28:2–23.

    Article  Google Scholar 

  • Duarte PC, Gomes-Filho JE, Ervolino E, Sundefeld MLMM, Tadahirowayama M, Lodi CS, et al. Histopathological condition of the remaining tissues after endodontic infection of rat immature teeth. J Endod. 2014;40(4):538–42.

    Article  Google Scholar 

  • Ehrenfest DMD, Andia I, Zumstein MA, Zhang CQ, Pinto NR, Bielecki T. Classification of platelet concentrates (Platelet-Rich Plasma-PRP, Platelet-Rich Fibrin-PRF) for topical and infiltrative use in orthopedic and sports medicine: current consensus, clinical implications and perspectives. Muscles Ligaments Tendons J. 2014;4(1):3–9.

    Google Scholar 

  • EzEldeen M, Gorp G van, Dessel J van, Vandermeulen D, Jacobs R. 3-dimensional analysis of regenerative endodontic treatment outcome. J Endod. 2015;41(3):317–24.

    Google Scholar 

  • Fouad AF, Verma P. Healing after regenerative procedures with and without pulpal infection. J Endod. 2014;40(4 Suppl):S58–64.

    Article  PubMed  Google Scholar 

  • Galler KM, D’Souza RN, Hartgerink JD, Schmalz G. Scaffolds for dental pulp tissue engineering. Adv Dent Res. 2011;23(3):333–9.

    Article  PubMed  Google Scholar 

  • Galler KM, Eidt A, Schmalz G. Cell-free approaches for dental pulp tissue engineering. J Endod. 2014;40(4 Suppl):S41–5.

    Article  PubMed  Google Scholar 

  • Galler KM, Krastl G, Simon S, Gorp G van, Meschi N, Vahedi B, et al. European Society of Endodontology Position Statement: Revitalisation Procedures. Int Endod J. 2016;49(8):717–23.

    Google Scholar 

  • Gronthos S, Mankani M, Brahim J, Robey PG, Shi S. Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo. Proc Nat Acad Sci USA. 2000;97(25):13625–30.

    Article  PubMed  PubMed Central  Google Scholar 

  • Hilkens P, Meschi N, Lambrechts P, Bronckaers A, Lambrichts I. Dental stem cells in pulp regeneration: near future or long road ahead? Stem Cells Dev. 2015;24(14):1610–22.

    Article  PubMed  Google Scholar 

  • Huang GT, Sonoyama W, Liu Y, Liu H, Wang S, Shi S. The hidden treasure in apical papilla: the potential role in pulp/dentin regeneration and bioroot engineering. J Endod. 2008;34(6):645–51.

    Article  PubMed  PubMed Central  Google Scholar 

  • Huang GT, Garcia-Godoy F. Missing concepts in de novo pulp regeneration. J Dent Res. 2014;93(8):717–24.

    Article  PubMed  PubMed Central  Google Scholar 

  • Iwaya SI, Ikawa M, Kubota M. Revascularization of an immature permanent tooth with apical periodontitis and sinus tract. Dent Traumatol. 2001;17(4):185–7.

    Article  PubMed  Google Scholar 

  • Laureys WG, Cuvelier CA, Dermaut LR, Pauw GA de. The critical apical diameter to obtain regeneration of the pulp tissue after tooth transplantation, replantation, or regenerative endodontic treatment. J Endod. 2013;39(6):759–63.

    Google Scholar 

  • Lin LM, Rosenberg PA. Repair and regeneration in endodontics. Int Endod J. 2011;44(10):889–906.

    Article  PubMed  Google Scholar 

  • Mao JJ, Kim SG, Zhou J, Ye L, Cho S, Suzuki T, et al. Regenerative endodontics: barriers and strategies for clinical translation. Dent Clin North Am. 2012;56(3):639–49.

    Article  PubMed  PubMed Central  Google Scholar 

  • Martin DE, Almeida JF de, Henry MA, Khaing ZZ, Schmidt CE, Teixeira FB, et al. Concentration-dependent effect of sodium hypochlorite on stem cells of apical papilla survival and differentiation. J Endod. 2014;40(1):51–5.

    Google Scholar 

  • Meschi N, Hilkens P, Lambrichts I, Eynde K van den, Mavridou A, Strijbos O, et al. Regenerative endodontic procedure of an infected immature permanent human tooth: an immunohistological study. Clin Oral Investig. 2016;20(4):807–14.

    Google Scholar 

  • Moreno-Hidalgo MC, Caleza-Jimenez C, Mendoza-Mendoza A, Iglesias-Linares A. Revascularization of immature permanent teeth with apical periodontitis. Int Endod J. 2014;47(4):321–31.

    Article  PubMed  Google Scholar 

  • Nagy MM, Tawfik HE, Hashem AA, Abu-Seida AM. Regenerative potential of immature permanent teeth with necrotic pulps after different regenerative protocols. J Endod. 2014;40(2):192–8.

    Article  PubMed  Google Scholar 

  • Nakashima M, Reddi AH. The application of bone morphogenetic proteins to dental tissue engineering. Nat Biotechnol. 2003;21(9):1025–32.

    Article  PubMed  Google Scholar 

  • Nevins M, Giannobile WV, McGuire MK, Kao RT, Mellonig JT, Hinrichs JE, et al. Platelet-derived growth factor stimulates bone fill and rate of attachment level gain: results of a large multicenter randomized controlled trial. J Periodontol. 2005;76(12):2205–15.

    Article  PubMed  Google Scholar 

  • Ostby BN. The role of the blood clot in endodontic therapy: an experimental histologic study. Acta Odontol Scand. 1961;19:324–53.

    Article  PubMed  Google Scholar 

  • Paryani K, Kim SG. Regenerative endodontic treatment of permanent teeth after completion of root development: a report of 2 cases. J Endod. 2013;39(7):929–34.

    Article  PubMed  Google Scholar 

  • Phumpatrakom P, Srisuwan T. Regenerative capacity of human dental pulp and apical papilla cells after treatment with a 3-antibiotic mixture. J Endod. 2014;40(3):399–405.

    Article  PubMed  Google Scholar 

  • Saoud TM, Zaazou A, Nabil A, Moussa S, Aly HM, Okazaki K, et al. Histological observations of pulpal replacement tissue in immature dog teeth after revascularization of infected pulps. Dent Traumatol. 2015;31(3):243–9.

    Article  PubMed  Google Scholar 

  • Torabinejad M, Milan M, Shabahang S, Wright KR, Faras H. Histologic examination of teeth with necrotic pulps and periapical lesions treated with 2 scaffolds: an animal investigation. J Endod. 2015;41(6):846–52.

    Article  PubMed  Google Scholar 

  • Vishwakarma A, Sharpe P, Ramalingam M. Stem cell biology and tissue engineering in dental sciences. London, UK: Elsevier; 2015.

    Google Scholar 

  • Wang J, Zhang H, Zhang W, Huang E, Wang N, Wu N, et al. Bone morphogenetic protein-9 effectively induces osteo/odontoblastic differentiation of the reversibly immortalized stem cells of dental apical papilla. Stem Cells Dev. 2014;23(12):1405–16.

    Article  PubMed  PubMed Central  Google Scholar 

  • Wigler R, Kaufman AY, Lin S, Steinbock N, Hazan-Molina H, Torneck CD. Revascularization: a treatment for permanent teeth with necrotic pulp and incomplete root development. J Endod. 2013;39(3):319–26.

    Article  PubMed  Google Scholar 

  • Zhu W, Zhu X, Huang GT, Cheung GS, Dissanayaka WL, Zhang C. Regeneration of dental pulp tissue in immature teeth with apical periodontitis using platelet-rich plasma and dental pulp cells. Int Endod J. 2013;46(10):962–70.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Departement Mondgezondheidswetenschappen, KU Leuven, UZ Leuven, Belgium

    N. Meschi & P. Lambrechts

Authors
  1. N. Meschi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. P. Lambrechts
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Oral Medicine, University of Washington, Seattle, Washington, USA

    J.K.M. Aps

  2. Gent, Belgium

    M. De Bruyne

  3. Department Beeldvorming & Pathologie - F, KU Leuven - OMFS-IMPATH Onderzoeksgroep, Leuven, Belgium

    R. Jacobs

  4. Praktijk voor Endodontologie, Zwolle, The Netherlands

    J. van der Meer

  5. MKA-chirurgie, Radboud UMC, Nijmegen, The Netherlands

    M.E.L. Nienhuijs

  6. Algemeen, Orthodontiepraktijktijk, Heerenveen, Friesland, The Netherlands

    S.C. Boxum

Copyright information

© 2016 Bohn Stafleu van Loghum

About this chapter

Cite this chapter

Meschi, N., Lambrechts, P. (2016). Regeneratie van pulpaweefsel. In: Aps, J., De Bruyne, M., Jacobs, R., van der Meer, J., Nienhuijs, M., Boxum, S. (eds) Het tandheelkundig jaar 2017. Bohn Stafleu van Loghum, Houten. https://doi.org/10.1007/978-90-368-1030-2_4

Download citation

  • DOI: https://doi.org/10.1007/978-90-368-1030-2_4

  • Published:

  • Publisher Name: Bohn Stafleu van Loghum, Houten

  • Print ISBN: 978-90-368-1029-6

  • Online ISBN: 978-90-368-1030-2

  • eBook Packages: Dutch language eBook collection

Publish with us

Policies and ethics

Search

Navigation