Abstract
Women addicted to cocaine often continue drug use through pregnancy, despite risks to the fetuses they are carrying. Primate studies have shown that intrauterine cocaine exposure (during a period corresponding to the second trimester in humans) results in a decrease in the number of neurons in the cerebral cortex and disorganization of the normal laminar structure of the cortex [56, 57]. Even brief exposure at a particularly vulnerable time in brain development may have lasting deleterious effects of greater magnitude than greater exposures at other times [58]. Moreover, the postnatal age at which the effects of cocaine are measured, whether in humans or animals, may show evolving outcomes [59]. In humans, the attribution of outcomes to drug effect is complicated by the observation that the circumstances under which children have been raised subsequent to cocaine exposure affect their behavior [60].
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Freye, E. (2009). Cocaine Use in Pregnancy. In: Pharmacology and Abuse of Cocaine, Amphetamines, Ecstasy and Related Designer Drugs. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-2448-0_15
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