Abstract
The interest in the elucidation of A3 adenosine receptor involvement in inflammation is evident from the large amount of experimental work carried out in peripheral blood cells of the immune system and in a variety of inflammatory conditions. Following a detailed analysis of the literature the A3 adenosine receptor subtype appears to play a complex role as both pro and anti-inflammatory effects have been demonstrated depending not only on the cell types investigated but also on the model of inflammation used and the species considered. This chapter will discuss developments in our understanding of the role of adenosine A3 receptor activation in the function of the different types of cells of the immune system including neutrophils, eosinophils, lymphocytes, monocytes, macrophages and dendritic cells.
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Gessi, S., Sacchetto, V., Fogli, E., Fozard, J. (2010). A3 Adenosine Receptor Regulation of Cells of the Immune System and Modulation of Inflammation. In: Borea, P. (eds) A3 Adenosine Receptors from Cell Biology to Pharmacology and Therapeutics. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-3144-0_12
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