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Heart

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Regenerative Medicine

Abstract

Coronary heart disease and chronic heart failure are common and have an increasing frequency. Although revascularisation procedures and conventional drug therapy may delay ventricular remodelling, there is no basic therapeutic regime available for preventing or even reversing this process. Chronic coronary artery disease and heart failure impair quality of life and are associated with subsequent worsening of the cardiac pump function. Numerous studies within the past few years have been demonstrated, that cardiac stem cell therapy has to be considered a safe therapeutic procedure in heart disease, when destroyed and/or compromised heart muscle must be regenerated. Different autologous or allogenic progenitor cell populations have been addressed for cardiac cell therapy. This kind of cell therapy with autologous bone marrow cells is completely justified ethical, except for the small numbers of patients with direct or indirect bone marrow disease (e.g. myeloma, leukaemic infiltration) in whom there would be intrinsic lesions of mononuclear cells. Several preclinical as well as clinical trials have shown that transplantation of autologous bone marrow stem cells or precursor cells improve cardiac function after myocardial infarction and in chronic ischemic heart disease. The age of infarction seems to be irrelevant to regenerative potency of stem cells, since stem cell therapy in old infarctions (many years old) is almost equally effective in comparison to previous infarcts. Further indications are non-ischemic and diabetic cardiomyopathy (dilated cardiomyopathy) as well as heart failure due to an infectious cause like Chagas heart disease. Further clinical development is aimed to modify cardiac inflammation and cardiogenesis by stem cell modification and to test other stem cell sources.

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Authors and Affiliations

  1. Department of Cardiac Surgery, University of Rostock, Schillingallee 35, 18057, Rostock, Germany

    Gustav Steinhoff

  2. Department of Cardiology, Pneumology and Angiology, Heinrich-Heine-University of Düsseldorf, Moorenstr. 5, 40225, Düsseldorf, Germany

    Bodo Eckehard Strauer

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  1. Gustav Steinhoff
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Correspondence to Gustav Steinhoff .

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  1. Klinik und Poliklinik für Herzchirurgie, Universitätsklinikum Rostock, Schillingallee 35, Rostock, 18057, Germany

    Gustav Steinhoff

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Steinhoff, G., Strauer, B.E. (2011). Heart. In: Steinhoff, G. (eds) Regenerative Medicine. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-9075-1_32

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