Abstract
Histamine neurons and histamine receptors have distributed in the brain and addressed in their implications of regulatory energy homeostasis. Several studies using agonist/antagonist of neuronal histamine and it’s receptors demonstrated that they have been shown to be involved in food intake and obesity. In addition, adipocytokine leptin regulates food intake and obesity partially via neuronal histamine and it’s receptors. Furthermore, recent studies have provided evidence that regulation of the diurnal rhythm of food intake through neuronal histamine is a crucial factor in the development of obesity. Thus, we focused on these roles of the neuronal histamine and it’s receptors in regulating the food intake and obesity.
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Abbreviations
- TMN:
-
tuberomammillary nucleus
- HDC:
-
histidine decarboxylase
- IP3:
-
inositol-1,4,5-triphosphate
- DAG:
-
1,2-diacylglycerol
- cAMP:
-
cyclic adenosine monophosphate
- α-FMH:
-
alpha-fluoromethylhistidine
- PVN:
-
paraventricullar nucleus
- UCPs:
-
uncoupling proteins
- IAs:
-
inverse agonists
- VLPO:
-
ventrolateral preoptic nucleus
- REM:
-
rapid eye movement
- WT:
-
wild-type
- ARC:
-
arcuate nucleus
- VMH:
-
ventromedial nucleus
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Masaki, T. (2010). The Neuronal Histamine and it’s Receptors as New Therapeutic Targets for Food Intake and Obesity. In: Khardori, N., Khan, R., Tripathi, T. (eds) Biomedical Aspects of Histamine. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-9349-3_13
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DOI: https://doi.org/10.1007/978-90-481-9349-3_13
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