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2 and 3D TOF-SIMS Imaging for Biological Analysis

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Detection of Biological Agents for the Prevention of Bioterrorism

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Abstract

Secondary ion mass spectrometry (SIMS) is an established technique in the field of surface analysis but until recently has played only a very small role in the area of biological analysis. This chapter provides an overview of the application of secondary ion mass spectrometry to the analysis of biological samples including single cells, bacteria and tissue sections. The chapter will discuss how the challenges of biological analysis by SIMS have created an impetus for the development of new technology and methodology giving improved mass resolution, spatial resolution and sensitivity.

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Author information

Authors and Affiliations

  1. Manchester Interdisciplinary Biocentre, University of Manchester, 131 Princess St., Manchester, UK

    John S. Fletcher

Authors
  1. John S. Fletcher
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Editor information

Editors and Affiliations

  1. , Science Branch, Fisheries and Oceans Canada, St. John's, A1C 5X1, Newfoundland and Labrador, Canada

    Joseph Banoub

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Fletcher, J.S. (2011). 2 and 3D TOF-SIMS Imaging for Biological Analysis. In: Banoub, J. (eds) Detection of Biological Agents for the Prevention of Bioterrorism. NATO Science for Peace and Security Series A: Chemistry and Biology. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-9815-3_18

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