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Environmental Heavy Metals and Mental Disorders of Children in Developing Countries

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Environmental Heavy Metal Pollution and Effects on Child Mental Development

Abstract

Environmental pollution is a product of urbanization and technology, and other attendant factors of population density, industrialization and mechanization that serve to provide the necessities of the population. For example, in cities of developing countries, the rural-urban migration activated by the search for increased incomes has resulted in the concentration of large populations in relatively small areas under poor conditions of sanitation. Traffic jams and the legendary ‘go-slow’ of automobiles are everyday occurrences in these cities. The impact of pollution in the vicinity of overcrowded cities and from industrial effluents and automobile exhausts has reached a disturbing magnitude and is arousing public awareness. At present, no enough data are available on the extent of environmental pollution because there are no agencies charged with the routine monitoring and protection of the environment. This chapter therefore focuses on the critical issues of heavy metals (HMs) pollution in rapidly developing nations. Once emitted from their sources, they have the property of accumulating in the environment for many years. They enter the human body through inhalation, ingestion, and dermal. They also can accumulate in the bodies of animals and humans before they even cause damage. However; HMs such as Lead (Pb), Cadmium (Cd), Arsenic (As), Manganese (Mn) Nickel (Ni), Chromium (Cr) and Mercury (Hg), are also metabolized in the body in a similar way to nutrient metals. Environmental exposure to HMs can occur through air, soil, drinking water and food stuff. The neurotoxic effects of exposure HMs in the environment, though insufficiently recognized, remains a topic of sub stantial current concern and interest as it could be considered an early endpoint for health effects induced by exposure to heavy metals.In addition, they can adversely affect the quality of life, and have broad health, social and economic implications. Special concern is directed to children as they are the most sensitive population exposed to environmental pollution in general and heavy metals in specific. Finally, the magnitude and potential severity of neurotoxicity problems make it imperative to direct researches towards preventive intervention, and focus on the development of new biomarkers for neurotoxicity at the individual and population levels with emphasis on health education about HMs exposure and their potential for neurotoxicity. The establishment of comprehensive monitoring systems and information gathering should be given priority by governments of the developing countries in the sub-region with support and encouragement from international agencies.

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References

  • Adhikari A, Penatti C.A., Resende R.R., Ulrich H., Britto L.R., Bechara E.J. 5-Aminolevulinate and 4,5-dioxovalerate ions decrease GABA(A) receptor density in neuronal cells, synaptosomes and rat brain. Brain Res. 2006; 1093(1): 95–104.

    Article  CAS  Google Scholar 

  • Alliance To End Childhood Lead Poisoning Report, (2000). Myths and realities of phasing out leaded gasoline.

    Google Scholar 

  • Ambrose T.M, Al-Lozi M., Scott M.G., Bone lead concentrations assessed by in vivo X-ray fluorescence. Clin Chem 2000; 46:1171−1178.

    Google Scholar 

  • Antonio MT, Corredor L., Leret M.L. Study of the activity of several brain enzymes like markers of the neurotoxicity induced by perinatal exposure to lead and/or cadmium. Toxicology Letters 2003; 143:331-340.

    Article  CAS  Google Scholar 

  • ATSDR Agency for Toxic Substances and Disease Registry, (1999). http://www.atsdr.cdc.gov/csem/cadmium/cdstandards_regulations.html

  • Audhya, T. (2004) “Nutritional intervention in autism.” Proc. Autism 1. Conf. June 28. Online: http://www.fltwood.com/onsite/autism/2004/03.shtml

  • Bahemuka, T.E., Mubofu, E.B., 1999. Heavy metals in edible green vegetables grown along the sites of the Sinza and Msimbazi rivers in Dar es Salaam, Tanzania. Food Chem. 1999; 66:63–66.

    Article  CAS  Google Scholar 

  • Bastias J.M, Munoz O, Moreno I., Rubilar C (2004) Evaluacion del contenido de arsenico y plomo en raciones de desayuno y almuerzos entregados a escolares de la VII region, Chile. CD Abstracts, XIII Latin American and Caribean Seminar on Food Science and Technology, Montevideo, Uruguay.

    Google Scholar 

  • Belitz HD, Grosch W, and Schieberle P, (2009). Food Chemistry, Springer Verlag.

    Google Scholar 

  • Bernard, S., Enayati, A., Redwood, L., Roger, H. and Binstock, T. “Autism: a novel formof mercury poisoning.” Med. Hypotheses 2001; 56:462–471.

    Article  CAS  Google Scholar 

  • Bibi S, Husain SZ AND Malik RN. Pollen Analysis and heavy metals detection in honey samples from seven selected countries. Pak. J. Bot., 2008; 40(2): 507-516.

    Google Scholar 

  • Bleich S, Lenz B, Ziegenbein M, Beutler S, Frieling H, Kornhuber J, Bo¨ nsch D. Epigenetic DNA hypermethylation of the HERP gene promoter induces down-regulation of its mRNA expression in patients with alcohol dependence. Alcohol Clin Exp Res. 2006; 30:587–91.

    Article  CAS  Google Scholar 

  • Bruce N, Perez-Padilla R and Albalak R. Indoor air pollution in developing countries: a major environmental and public health challenge. Bull World Health Organ 2000; 78(9).

    Google Scholar 

  • Bulinski, R., L. Wyszogrodzka-koma, and Z. Marzec. Study on some trace element contents in Polish food products. Bromatologia-i-chemia-Toksykologiczan 1995; 28(2): 151–4.

    CAS  Google Scholar 

  • Carmen, A., and Cristina M. Environmental pollution and its effects on honey quality. The Roumanian Biotechnological Letters 6, no. 5: 371–9.

    Google Scholar 

  • Caroli SG. Alessandrelli FM, Cresti R, Spagnoli M, D’llio S, Pauwels Jz, and Kramer GN. A pilot study for the prediction of a certified reference material for trace elements in honey. Michrochemical Journal 2000; 67: 227–33.

    Article  CAS  Google Scholar 

  • Chanda S, Dasgupta UB, Guhamazumder D, Gupta M, Chaudhuri U, Lahiri S, Das S, Ghosh N, Chatterjee D. DNA hypermethylation of promoter of gene p53 and p16 in arsenic exposed people with and without malignancy. Toxicol Sci. 2006;89:431–7.

    Article  CAS  Google Scholar 

  • Chapman TL, (2008). Genetic Heavy Metal Toxicity: Explaining SIDS, Autism, Tourette’s, Alzheimer’s and Other Epidemics, iUniverse Inc.

    Google Scholar 

  • Chen H, Li S, Liu J, Diwan B.A, Barrett J.C, Waalkes M.P. Chronic inorganic arsenic exposure induces hepatic global and individual gene hypomethylation: implications for arsenic hepatocarcinogenesis. Carcinogenesis. 2004;25:1779–86.

    Article  CAS  Google Scholar 

  • Chen H, Liu J, Zhao C.Q., Diwan B.A., Merrick BA, Waalkes M.P. Association of c-myc overexpression and hyperproliferation with arsenite-induced malignant transformation. Toxicol Appl Pharmacol. 2001;175:260–8.

    Article  CAS  Google Scholar 

  • Chiodo LM Jacobson S.W. and Jacobson J.L. Neurodevelopmental effects of postnatal lead exposure at very low levels. Neurotoxicology and Teratology 2004; 26(3):359-371.

    Article  CAS  Google Scholar 

  • Crumpton T, Atkins D.S, Zawia N.H, Barone S Jr. Lead exposure in pheochromocytoma (PC12) cells alters neural differentiation and Sp1 DNA-binding. Neurotoxicology. 2001;22(1):49-62.

    Article  CAS  Google Scholar 

  • Dalbokova D, Krzyzanowski M, Loyd S, (2007). Children’s health and environment in Europe: A baseline assessment. World Health Organization.

    Google Scholar 

  • Daniell WE, Stockbridge HL, Labbe RF, Woods JS, Anderson KE, Bissell DM, Bloomer JR, Ellefson R.D, Moore M.R, Pierach C.A, Schreiber W.E, Tefferi A, and Franklin G.M Environmental Chemical Exposures and Disturbances of Heme Synthesis. Environ Health Perspect 1997; 105(Suppl 1):37-53.

    Article  CAS  Google Scholar 

  • De Castro, E., Ferreira, H., Cunha, M., Bulcao, C., Sarmento, C., De Oliveira, I., Fregoneze, J.B., 1996. Effect of central acute administration of cadmium on drinking behavior. Pharmacol. Biochem. Behav. 53 (3), 687-/693.

    Article  Google Scholar 

  • De Vries W, Romkens P.F., and Schutze G. Critical Soil Concentrations of Cadmium, Lead, and Mercury in View of Health Effects on Humans and Animals. Rev Environ Contam Toxicol 2007; 191:91–130.

    Article  CAS  Google Scholar 

  • Dillner AM, Schauerhttp://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6VH3-4FC3RN4-2&_user=10&_coverDate=03%2F31%2F2005&_rdoc=1&_fmt=high&_orig=search&_sort=d&_docanchor=&view=c&_searchStrId=1352741192&_rerunOrigin=scholar.google&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=aa01b05994197b0bba4a63ff2d172c2a - aff2 JJ, Christensen WF and Cass GR. A quantitative method for clustering size distributions of elements. Atmospheric Environment. 2005; 39(8):1525-1537.

    Google Scholar 

  • Dogheim SM, El-Ashraf MM, Gad Alla SA, Khorshid MA, Fahmy SM. Pesticides and heavy metals levels in Egyptian leafy vegetables and some aromatic medicinal plants. Food Addit. Contam. 2004; 21(4):323–330.

    CAS  Google Scholar 

  • Dolinoy DC, Weidman JR, Jirtle RL. Epigenetic gene regulation: Linking early developmental environment to adult disease. Reprod Toxicol. 2007;23:297–307.

    Article  CAS  Google Scholar 

  • EEPP (Egyptian Environmental Policy Program) 2004,. Ambient air Quality Status Report. Technical support document for the development of the National Air Quality Strategy Framework.

    Google Scholar 

  • Erickson T, Ahrens WR, Aks S, Baum C and Ling L, (2004). Pediatric Toxicology: Diagnosis and Management of the Poisoned Child. (1st edition ), McGraw-Hill Professional.

    Google Scholar 

  • Erzen I, Kragelj LZ. Cadmium concentrations in blood in a group of male recruits in Slovenia related to smoking habits. Bull Environ Contam Toxicol. 2006;76(2):278-84.

    Article  CAS  Google Scholar 

  • Ezzati M and Kammen DM. Quantifying the effects of exposure to indoor air pollution from biomass combustion on acute respiratory infections in developing countries. Environ Health Perspect. 2001; 109(5):481–488.

    Article  CAS  Google Scholar 

  • Faridah HW, Wilson N, Jane M and Ruth W, Use of human nails as bio-indicators of heavy metals environmental exposure among school age children in Kenya. Science of the total environment 2008; 393:376-384.

    Article  CAS  Google Scholar 

  • Faustman EM, Silbernagel SM, Fenske RA, Burbacher TM, and Ponce RA. Mechanisms underlying Children’s susceptibility to environmental toxicants. Environ Health Perspect. 2000; 108(Suppl 1):13–21.

    Article  CAS  Google Scholar 

  • Fernandez-Torres R, Bernal JL, Lopez MA, Mochon MC, Sanchez JC, and Perez AG. Mineral content and botanical origin of Spanish honeys. Talanta 2005; 65: 686–91.

    Article  CAS  Google Scholar 

  • Fernando B Jr., Jose ET, Raquel FG, and Patrick JP, A Critical Review of Biomarkers Used for Monitoring Human Exposure to Lead: Advantages, Limitations, and Future Needs. Environmental Health Perspectives, 2005; 113(12):1669-1674.

    Article  CAS  Google Scholar 

  • Fido, A. and Al Saad, S. “Toxic trace elements in the hair of children with autism.” Autism. 2005; 9:290–298.

    Article  Google Scholar 

  • Fowler BA, Whittaker MH, Lipsky M, Wang G, Chen XQ. Oxidative stress induced by lead, cadmium and arsenic mixtures: 30-day, 90-day, and 180-day drinking water studies in rats: an overview. Biometals. 2004; 17:567–8.

    Article  CAS  Google Scholar 

  • Giedd JN, Structural magnetic resonance imaging of the adolescent brain. Ann. NY academy of sci. 2004; 1021:77-85.

    Article  Google Scholar 

  • Gioia GA, Isquith PK, Guy SC, Kenworthy L. Behavior rating inventory of executive functions. Odessa, FL: Psychological Assessment Resources, Inc.; 2000.

    Google Scholar 

  • Goldman L and Coussens CM (Ed), (2004). Environmental Health Indicators: Bridging the Chasm of Public Health and the Environment - Workshop Summary, Roundtable on Environmental Health Sciences, Research, and Medicine, National Academies Press.

    Google Scholar 

  • Gomes VE, de Sousa MDLR, Barbosa F, Krug FJ, Saraiva MDCP, Cury JA, et al. In vivo studies on lead content of deciduous teeth superficial enamel of preschool children. Sci Total Environ 2004; 320:25–35.

    Article  CAS  Google Scholar 

  • Harry GJ and Hugh A, (2010). Neurotoxicology, Third Edition (Target Organ Toxicology Series), 3rd edition. Tilson, Informa Healthcare.

    Google Scholar 

  • Hassanien AM (1991). Effects of heavy metals on cholinergic enzyme activities in selected tissues of two mammals. M.Sc. thesis, faculty of Science, Cairo University, Egypt.

    Google Scholar 

  • Hassanien AM (2009). Risk Estimates of Air Pollutants in Developing Countries. In Exposure and Risk Assessment of Chemical Pollution - Contemporary Methodology, edited by Lubomir I. Simeonov and Mahmoud A. Hassanien. Published by Springer.

    Google Scholar 

  • Hedge S, Sridhar M, Bolar DR, Bhaskar SR & Sandhavi MB. Relating tooth- and blood-lead levels in children residing near a zinc–lead smelter in India. International Journal of Paediatric Dentistry. 2010; 20(3):186-192.

    Article  Google Scholar 

  • Holmes AS (2003) Chelation of Mercury for the Treatment of Autism. http://www.healing-arts.org/children/holmes.htm.

  • Holmes AS, Blaxill MF, and Haley BE. Reduced Levels of Mercury in First Baby Haircuts of Autistic Children. International Journal of Toxicology, 2003; 22:277–285.

    Article  CAS  Google Scholar 

  • Horiguchia H, Oguma E, Sasaki S, Miyamoto K, Ikeda Y, Machida M and Kayama F. Dietary exposure to cadmium at close to the current provisional tolerable weekly intake does not affect renal function among female Japanese farmers. Environmental Research 2004; 95(1): 20-31.

    Article  CAS  Google Scholar 

  • Jiang Y, Shi H, Li J, Shen C, Liu J and Yang H. Environmental Lead Exposure Among Children in Chengdu, China: Blood Lead Levels and Major Sources. Bulletin of Environmental Contamination and Toxicology. 2010; 84(1):1-4

    Article  CAS  Google Scholar 

  • Karahalila B, Aykanata B and Ertas N. Dental lead levels in children from two different urban and suburban areas of Turkey. International Journal of Hygiene and Environmental Health 2007; 210(2):107-112.

    Article  CAS  Google Scholar 

  • Karavoltsos, S., Sakellari, A., Dimopoulos, M., Dasenakis, M., Scoullos, M. Cadmium content in foodstuffs from the Greek market. Food Addit. Contam. 2002; 19(10):954–962.

    CAS  Google Scholar 

  • Kenneth R. Spaeth, Antonios J. Tsismenakis and Stefanos N. Kales, (2010). Heavy Metals: A Rapid Clinical Guide to Neurotoxicity and Other Common Concerns. Nova Science Pub Inc.

    Google Scholar 

  • Khan MI, Mahdi AA, Islam N, Rastogi SK, and Negi MP. Assessment of erythrocyte acetylcholine esterase activities in painters. Indian J Occup Environ Med. 2009; 13(1): 23–27.

    Article  Google Scholar 

  • Kramer. A pilot study for the prediction of a certified reference material for trace elements in honey. Michrochemical Journal 2000; 67: 227–33.

    Article  Google Scholar 

  • Kuloglu E & Tuncel G. Size Distribution of Trace Elements and Major Ions in the Eastern Mediterranean Atmosphere. Water, Air, & Soil Pollution, 2005; 167(1-4):221-241.

    Article  CAS  Google Scholar 

  • Kumar, A., Dey, P.K., Singla, P.N., Ambasht, R.S. and Upadhyay, S.K. “Blood lead levels in children with neurological disorders.” J. Trop. Pediatr. 1998; 44:320–322.

    Article  CAS  Google Scholar 

  • Lathe R, (2004). Autism, Brain, and Environment, Jessica Kingsley Publishers.

    Google Scholar 

  • Lazaridis M (ed) and Colbeck I. Human (2010). Exposure to Pollutants via Dermal Absorption and Inhalation, Environmental Pollution Series 17: 1-39. Springer, Netherlands.

    Google Scholar 

  • Licari L, Tamburlini G, (2007). Children’s health and environment - Developing action plans, World Health Organization.

    Google Scholar 

  • Lippmann M, (2009). Environmental Toxicants- Human Exposures and Their Health Effects, 3rd Edition. Wiley Interscience.

    Google Scholar 

  • Lonsdale, D., Shamberger, R.J. and Audhya, T. “Treatment of autism spectrum children with thiamine tetrahydrofurfuryl disulfide: a pilot study.” Neuroendocrinol. Lett. 2002; 23:303-308.

    CAS  Google Scholar 

  • Mazzocco MLM and Ross JL (ed), (2007). Neurogenetic Developmental Disorders -Variation of Manifestation in Childhood, MIT Press.

    Google Scholar 

  • McCally M (ed), (2002). The Environment and Human Health, MIT press.

    Google Scholar 

  • McVeigh GE, Allen PB, Morgan DR, Hanratty CG, Silke B. Nitric oxide modulation of blood vessel tone identified by arterial waveform analysis. Clin Sci (Lond). 2001;100:387–93.

    Article  CAS  Google Scholar 

  • Mostafa GA, El-Shahawi HH, Mokhtar A. Blood lead levels in Egyptian children from high and low lead-polluted areas: impact on cognitive function. Acta Neurologica Scandinavica. 2009; 120(1):30-37.

    Article  CAS  Google Scholar 

  • Nambudripad DS (2007). Freedom from Chemical Sensitivities: Explore NAET (Nambudripad’s Allergy Elimination Techniques), Delta Publishers

    Google Scholar 

  • Nordberg GF, Fowler BA, Nordberg M, Friberg L (eds), (2007) Handbook on the Toxicology of Metals, 3rd edition, Academic Press.

    Google Scholar 

  • Nowak B, Chmielnicka J. Relationship of lead and cadmium to essential elements in hair, teeth and nails of environmentally exposed people. Toxicol Environ Saf 2002;46: 265–74.

    Article  CAS  Google Scholar 

  • Obiria S, Dodood DK, Armah FA, Essumang DK and Cobbina SJ. Evaluation of lead and mercury neurotoxic health risk by resident children in the Obuasi municipality, Ghana. Environmental Toxicology and Pharmacology, 2010; 29(3):209-212.

    Article  CAS  Google Scholar 

  • Olewe TM, Mwanthi MA, Wang’ombe JK and Griffiths JK. Blood lead levels and potential environmental exposures among children under five years in Kibera slums, Nairobi. Journal of Applied Biosciences 2009; 13:688-694.

    Google Scholar 

  • Olympio KPK, Gonçalves C, Günther WMR, Bechara EJH. Neurotoxicity and aggressiveness triggered by low-level lead in children: a review. Pan Am J Public Health. 2009;26(3):266–75.

    Google Scholar 

  • Palmer, R.F., Blanchard, S., Stein, Z., Mandell, D. and Miller, C. (2006) “Environmental mercury release, special education rates, and autism disorder: an ecological study of Texas.” Health & Place 12, 203–209.

    Article  Google Scholar 

  • Parveen, Z., Khuhro, M.I., Rafiq, N. Market basket survey for lead, cadmium, copper, chromium, nickel and zinc in fruits and vegetables. Bull. Environ. Contam. Toxicol. 2003; 71:1260–1264.

    Article  CAS  Google Scholar 

  • Pennington, J., Schoen, S., Salmon, G., Young, B., John, R., Mart, R. Composition of core foods of the USA food supply 1982–1991.II. Calcium, magnesium, iron and zinc. J. Food Compos. Anal. 1995a; 8:129–169.

    Article  CAS  Google Scholar 

  • Pennington, J., Schoen, S., Salmon, G., Young, B., John, R., Mart, R. Composition of core foods of the USA food supply 1982–1991.III. Copper, manganese, selenium and iodine. J. Food Compos. Anal. 1995b; 8:171–217.

    Article  CAS  Google Scholar 

  • Queirolo EI, Ettinger AS, Stoltzfus RJ and Kordas K. Association of Anemia, Child and Family Characteristics With Elevated Blood Lead Concentrations in Preschool Children From Montevideo, Uruguay. Archives of Environmental and Occupational Health 2010; 65(2):94–100.

    Article  Google Scholar 

  • Radwan MA and Salama AK, Market basket survey for some heavy metals in Egyptian fruits and vegetables. Food and Chemical Toxicology 2006; 44:1273–1278.

    Article  CAS  Google Scholar 

  • Rahlenbeck, S.I., Burberg, A., Zimmermann, R.D. Lead and cadmium in Ethiopian vegetables. Bull. Environ. Contam. Toxicol. 1999; 62:30–33.

    Article  CAS  Google Scholar 

  • Rashed, M. N., El-Haty, M. T. A. and Mohamed, S. M.(2009) ’Bee honey as environmental indicator for pollution with heavy metals’, Toxicological & Environmental Chemistry, 91: 3, 389—403.

    Article  CAS  Google Scholar 

  • Rashed, MN, and Soltan ME. Major and trace elements in different types of Egyptian mono floral and non-floral bee honeys. Journal of Food Composition and analysis 2004; 17: 725–35.

    Article  CAS  Google Scholar 

  • Reichard JF, Schnekenburger M, Puga A. Long term low-dose arsenic exposure induces loss of DNA methylation. Biochem Biophys Res Commun. 2007;352:188–92.

    Article  CAS  Google Scholar 

  • Rice D and Barone S (Jr). Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models. Environ Health Perspect. 2000;108(Suppl 3):511–533.

    Article  Google Scholar 

  • Roberts JR, Reigart JR, Ebeling M, Hulsey TC. Time required for blood lead levels to decline in nonchelated children. Clin Toxicol 2001; 39:153–160.

    Article  CAS  Google Scholar 

  • Roumanian Biotechnological Letters 2001; 6(5): 371–9.

    Google Scholar 

  • Sadia B, Syed ZH and Riffat NM. Pollen analysis and heavy metals detection in honey samples from seven selected countries, Pak. J. Bot., 40(2): 507-516, 2008.

    Google Scholar 

  • Samatha G, Sharma R, Roychowdhury T, Charkraborti D. Arsenic and other elements in the hair, nails and skin scales of arsenic victims in West Bengal India. Sci Total Environ 2004; 326:30–45.

    Google Scholar 

  • Sanchez ML, (2008). Causes and effects of heavy metal pollution. Nova Science Publishers, Inc., New York.

    Google Scholar 

  • Sarkar B (ed), (2002). Heavy Metals in the Environment. MARCEL DEKKER INC. NEW YORK - BASEL.

    Book  Google Scholar 

  • Scheuplein R, Charnley G, and Dourson M. Differential Sensitivity of Children and Adults to Chemical Toxicity: I. Biological Basis Regulatory Toxicology and Pharmacology. 2002; 35(3):429-447.

    Article  CAS  Google Scholar 

  • Schmidt RH, Rodrick GE, (2005). Food Safety Handbook, Wiley InterScience.

    Google Scholar 

  • Schwartz MS, Benci JL, Selote DS, Anuj K. Sharma AK, Chen AG, Dang H, Fares H, and Vatamaniuk OK. Detoxification of Multiple Heavy Metals by a Half-Molecule ABC Transporter, HMT-1, and Coelomocytes of Caenorhabditis elegans. PLoS One. 2010; 5(3): e9564.

    Article  CAS  Google Scholar 

  • Sciandrello G, Caradonna F, Mauro M, Barbata G. Arsenic-induced DNA hypomethylation affects chromosomal instability in mammalian cells. Carcinogenesis. 2004;25:413–7.

    Article  CAS  Google Scholar 

  • Selevan SG, Kimmel CA and Mendola P. Identifying critical windows of exposure for children’s health. Environ Health Perspect. 2000;108(Suppl 3):451–455.

    Article  Google Scholar 

  • Sharaf NE, Abdel-Shakour A, Amer NM, Abou-Donia MA and Khatab N. Evaluation of Children’s Blood Lead Level in Cairo, Egypt. American-Eurasian J. Agric. & Environ. Sci., 2008; 3 (3): 414-419.

    Google Scholar 

  • Takiguchi M, Achanzar WE, Qu W, Li G, Waalkes MP. Effects of cadmium on DNA-(Cytosine-5) methyltransferase activity and DNA methylation status during cadmium-induced cellular transformation. Exp Cell Res. 2003;286:355–65.

    Article  CAS  Google Scholar 

  • Tchernitchin AN, Tchernitchin NN, Mena MA. Imprinting: perinatal exposures cause the development of diseases during the adult age. Acta Biol Hung. 1999;50(4):425-40.

    CAS  Google Scholar 

  • Thakur JS, Prinja S, Singh D, Rajwanshi A, Prasad R, Parwana HK and Kumar R. Adverse reproductive and child health outcomes among people living near highly toxic waste water drains in Punjab, India, J Epidemiol Community Health 2010;64:148-154.

    Article  Google Scholar 

  • Todd AC, Parsons PJ, Tang SD, Moshier EL. Individual variability in human tibia lead concentration. Environ Health Perspect 2001; 109:1139–1143.

    Article  CAS  Google Scholar 

  • Tong S, von Schirnding YE, Prapamontol T. Environmental lead exposure: a public health problem of global dimensions. [Review]. Bull World Health Organ 2000; 78: 1068-77.

    CAS  Google Scholar 

  • Tulin Ayse Ozdena, Gulbin Gokçaya, Hayriye Vehid Ertema, Ozlem Durmaz Suoglua, Ayse Kılıca, Semra Sokucub and Gunay Sanera. Elevated hair levels of cadmium and lead in school children exposed to smoking and in highways near schools Clinical Biochemistry 2007; 40(1-2):52-56.

    Google Scholar 

  • United Nations Environment Program (UNEP) Chemicals Branch (2006). Lead and Cadmium Working Group: First meeting Geneva, UNEP-Chemicals, Geneva.

    Google Scholar 

  • United Nations Environment Program (UNEP) Chemicals Branch (2008). The Global Atmospheric Mercury Assessment: Sources, Emissions and Transport. UNEP-Chemicals, Geneva.

    Google Scholar 

  • United Nations Environment Program (UNEP), (2008). Interim review of scientific information on lead.

    Google Scholar 

  • Uren, A, Serifoglu A, and Sarikahya Y. Distribution of elements in honeys and effect of a thermoelectric power plant on the element contents. Food Chemistry 1998; 61: 185–90.

    Article  CAS  Google Scholar 

  • US Geological Survey (2010). Mineral Commodity Report.

    Google Scholar 

  • Valinluck V, Tsai HH, Rogstad DK, Burdzy A, Bird A, Sowers LC. Oxidative damage to methyl-CpG sequences inhibits the binding of the methyl-CpG binding domain (MBD) of methyl-CpG binding protein 2 (MeCP2). Nucleic Acids Res. 2004;32:4100–8.

    Article  CAS  Google Scholar 

  • Valverde M, Fortoul TI, Diaz Barriga F, Mejia J; Del Castillo ER. Genotoxicity induceced in Cd – 1 mice by inhaled lead: differential organ response. Mutagenesis. 2002; 17(1):55-61.

    Article  CAS  Google Scholar 

  • Wang CN, Songa XY, Gaob Q, Wanga F, Liu P and Wu YN. Dietary exposure to lead by children and adults in the Jinhu area of China Food Additives and Contaminants. 2009; 26(6):821–828.

    CAS  Google Scholar 

  • Ware GW, Whitacre DM, (2007). Reviews of Environmental Contamination and Toxicology, Volume 185, Springer Verlag.

    Google Scholar 

  • Weiss B. Vulnerability of children and the developing brain to neurotoxic hazards. Environ Health Perspect. 2000; 108(Suppl 3): 375–381.

    Article  Google Scholar 

  • WennbergM, Lundhhttp://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WDS-4H99JGV-2&_user=10&_coverDate=03%2F31%2F2006&_rdoc=1&_fmt=high&_orig=search&_sort=d&_docanchor=&view=c&_searchStrId=1352745675&_rerunOrigin=scholar.google&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=d6164eac3e0e69b8f146e45b90f4a935 - aff3 T, Bergdahl IA, Hallmanshttp://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WDS-4H99JGV-2&_user=10&_coverDate=03%2F31%2F2006&_rdoc=1&_fmt=high&_orig=search&_sort=d&_docanchor=&view=c&_searchStrId=1352745675&_rerunOrigin=scholar.google&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=d6164eac3e0e69b8f146e45b90f4a935 - aff2 G, Jansson JH, Stegmayrhttp://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WDS-4H99JGV-2&_user=10&_coverDate=03%2F31%2F2006&_rdoc=1&_fmt=high&_orig=search&_sort=d&_docanchor=&view=c&_searchStrId=1352745675&_rerunOrigin=scholar.google&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=d6164eac3e0e69b8f146e45b90f4a935 - aff2 B, Custodiohttp://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WDS-4H99JGV-2&_user=10&_coverDate=03%2F31%2F2006&_rdoc=1&_fmt=high&_orig=search&_sort=d&_docanchor=&view=c&_searchStrId=1352745675&_rerunOrigin=scholar.google&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=d6164eac3e0e69b8f146e45b90f4a935 - aff3 HM and Skerfving S. Time trends in burdens of cadmium, lead, and mercury in the population of northern Sweden. Environmental Research 2006; 100(3):330-338.

    Google Scholar 

  • WHO World Health Organization (2004). Cadmium in Drinking-water, Background document for development of WHO Guidelines for Drinking-water Quality, World Health Organization, Geneva.

    Google Scholar 

  • World Health Organisation (WHO) (1992). Environmental Health Criteria 134 - Cadmium International Programme on Chemical Safety (IPCS) Monograph.

    Google Scholar 

  • World Health Organization, (2007). Health risks of heavy metals from long-range transboundary air pollution Joint WHO/Convention Task Force on the Health Aspects of Air Pollution.

    Google Scholar 

  • Wright RO and Baccarelli A. Metals and Neurotoxicology, Symposium: Heavy Metal Exposures in Women and Children, American Society for Nutrition J. Nutr. 2007; 137:2809-2813

    CAS  Google Scholar 

  • Wright RO, Amarasiriwardena C, Woolf AD, Jim R and Bellinger DC. NeuroToxicology Neuropsychological correlates of hair arsenic, manganese, and cadmium levels in school-age children residing near a hazardous waste site, 2006, 27:210–216.

    CAS  Google Scholar 

  • Wyrwala EM, Dziubaneka G, Skrzypek M and Hajok I. Study of the health effects of long-term exposure to cadmium and lead in a region of Poland, International Journal of Environmental Health Research, 2010; 20(2):81-86.

    Article  CAS  Google Scholar 

  • Zawia NH, Crumpton T, Brydie M, Reddy GR, Razmiafshari M. Disruption of the zinc finger domain: a common target that underlies many of the effects of lead. Neurotoxicology. 2000; 21(6):1069-80.

    CAS  Google Scholar 

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Correspondence to Mahmoud A. Hassanien .

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Hassanien, M.A., Shahawy, A.M.E. (2011). Environmental Heavy Metals and Mental Disorders of Children in Developing Countries. In: Simeonov, L., Kochubovski, M., Simeonova, B. (eds) Environmental Heavy Metal Pollution and Effects on Child Mental Development. NATO Science for Peace and Security Series C: Environmental Security, vol 1. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-0253-0_1

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