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Radiotherapy—A New Approach to Risk-Adapted Selective Radiotherapy

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Breast Cancer, a Heterogeneous Disease Entity

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Abstract

During the past forty years, breast-conserving surgery followed by whole breast irradiation (with or without an additional dose to the tumour bed) has become the standard of care for the treatment of early-stage (St. 0-I-II) breast carcinoma. With the advent of breast screening, the incidence of breast carcinomas with more favourable prognostic characteristics (including in situ, microinvasive and invasive tumours measuring up to 15 mm) has increased significantly. This change in the prognostic profile of newly diagnosed breast cancers has opened up new horizons for clinical research seeking individual risk-adapted protocols of breast cancer radiotherapy. Several groups have tested the efficacy of accelerated (partial or whole) breast irradiation, which has become the new treatment paradigm in the radiotherapy of low-risk breast cancers. Others have attempted to identify subgroups of patients for whom radiotherapy after breast-conserving surgery could be safely omitted. This chapter reviews the results of such studies, focusing on risk-adapted radiotherapy after breast-conserving surgery for patients with small (≤15 mm), low-risk breast carcinomas.

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  1. Department of Radiotherapy, National Institute of Oncology, Ráth Gy. u. 7-9, 1122, Budapest, Hungary

    Csaba Polgár

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  1. , University of Szeged, Department of Oncotherapy, Korányi fasor 12, Szeged, 6720, Hungary

    Zsuzsanna Kahán

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Polgár, C. (2011). Radiotherapy—A New Approach to Risk-Adapted Selective Radiotherapy. In: Kahán, Z. (eds) Breast Cancer, a Heterogeneous Disease Entity. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-0489-3_9

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