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Evidence-based Anticancer Materia Medica for Colorectal Cancer

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Materia Medica for Various Cancers

Part of the book series: Evidence-based Anticancer Complementary and Alternative Medicine ((ACAM,volume 2))

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Abstract

Unfortunately, majority of patients with metastatic colorectal cancer cannot be cured. Current available systemic chemotherapy and targeted agents produce meaningful improvement in median survival and progression free survival. However toxicity associated with these therapies can worsen the quality of life for patients. Therefore there is an interest in looking at alternative medicine to reduce the side effect and possibly enhance the efficacy of cytotoxic chemotherapy. There are a large number of preclinical studies looking at ginseng products as chemopreventive agents. They induce apoptosis and cytotoxicity in multiple colorectal cell lines but lack of definitive clinical studies. Both curcumin and thymoquinone show promising preclinical data in vitro and in vivo but lack of clinical efficacy studies. There is emerging preclinical data that herbal products in combination with chemotherapy can reduce toxicity and enhance the cytotoxicity of chemotherapeutic agents like 5-fluorouracil. However there is discordance between the amount of preclinical data available and what herbal agents are tested in clinical trial setting. In this chapter, we will review the current data available for herbal medicine in the treatment of advanced colorectal cancer.

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Authors and Affiliations

  1. Department of Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, MI, 48202, USA

    Minsig Choi & Ramzi Mohammad

  2. Department of Hem-Onc and Section of GI Cancers, Columbia University College of Physicians and Surgeons & New York Presbyterian Hospital, New York, NY, 10032, USA

    M. Wasif Saif

  3. Department of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center, Tampa, FL, 33612, USA

    Richard Kim

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  1. Minsig Choi
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  2. Ramzi Mohammad
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  3. M. Wasif Saif
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  4. Richard Kim
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Correspondence to M. Wasif Saif .

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Editors and Affiliations

  1. Queen Elizabeth Hospital, Department of Clinical Oncology, Room 1305, 13/F, Block R, Gascoigne Road 30, Kowloon, Hong Kong, China, People's Republic

    William C.S. Cho

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Choi, M., Mohammad, R., Saif, M.W., Kim, R. (2012). Evidence-based Anticancer Materia Medica for Colorectal Cancer. In: Cho, W. (eds) Materia Medica for Various Cancers. Evidence-based Anticancer Complementary and Alternative Medicine, vol 2. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-1983-5_2

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