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Mesenchymal Stem Cells: Role of Mechanical Strain in Promoting Apoptosis and Differentiation

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Stem Cells and Cancer Stem Cells,Volume 3

Part of the book series: Stem Cells and Cancer Stem Cells ((STEM,volume 3))

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Abstract

Physical forces play an important role in regulating cell proliferation, differentiation, and fate by activating specific intracellular signal transduction pathways. Mesenchymal stem cells (MSCs) are adult stem cells which may represent ideal cells for use in cell-based skeletal tissue engineering strategies. However, further research into MSC biology is required to fully appreciate and utilise the broad therapeutic potential of MSCs. Mechanical conditioning has been widely utilised as a biophysical signal to aid cell-based tissue engineering applications. Mechanical strain has shown the ability to induce differentiation of MSCs along osteogenic, chondrogenic and myogenic lineages. However, there is also evidence of a rate-dependent apoptotic response to mechanical strain in MSCs. This dualistic response to mechanical strain highlights the necessity to regulate and understand the underlying mechanisms involved in the priming of these cells for use in the tissue engineering field.

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Authors and Affiliations

  1. Department of Physiology and Institute of Neuroscience, School of Medicine, Trinity College, University of Dublin, Dublin 2, Ireland

    Katey K. McKayed, Veronica A. Campbell & Aoife Gowran

  2. Trinity Centre for Bio-engineering, School of Engineering, Trinity College, University of Dublin, Dublin 2, Ireland

    Katey K. McKayed, Patrick J. Prendergast & Veronica A. Campbell

Authors
  1. Katey K. McKayed
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  2. Patrick J. Prendergast
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  3. Veronica A. Campbell
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  4. Aoife Gowran
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Corresponding author

Correspondence to Aoife Gowran .

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Editors and Affiliations

  1. , Kean University, Room 213, Library building, Morris Avenue 1000, Union, 07083, New Jersey, USA

    M.A. Hayat

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McKayed, K.K., Prendergast, P.J., Campbell, V.A., Gowran, A. (2012). Mesenchymal Stem Cells: Role of Mechanical Strain in Promoting Apoptosis and Differentiation. In: Hayat, M. (eds) Stem Cells and Cancer Stem Cells,Volume 3. Stem Cells and Cancer Stem Cells, vol 3. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2415-0_19

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