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Neuroblastoma Patients: Plasma Growth Factor Midkine as a Prognostic Growth Factor

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Neuroblastoma

Part of the book series: Pediatric Cancer ((PECA,volume 1))

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Abstract

Neuroblastoma is the most common solid tumor of childhood, and its prognosis remains poor. The statuses of MYCN amplification, TRKA expression, ploidy, stage and age are prognostic factors of this cancer. A reliable blood marker for neuroblastoma has long been awaited. The growth factor midkine was originally discovered as the protein product of a retinoic acid-responsive gene. It has been revealed that midkine is involved in cancer progression: it is highly expressed in human carcinomas, and its depletion leads to tumor growth suppression in animal models. Here, we describe plasma midkine level as a prognostic factor for neuroblastoma. Plasma midkine level is closely associated with the above-mentioned prognostic factors. Moreover, there is a striking correlation between high plasma midkine level and poor prognosis. Plasma midkine level could be a useful biomarker not only for predicting patient outcome but also for monitoring tumor status during therapy.

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Acknowledgement

This work was supported by Grants-in-Aid from the Ministry of Education, Science, Sports, Culture and Grants-in-Aid from the Ministry of Health.

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Authors and Affiliations

  1. Department of Biochemistry, Nagoya University Graduate School of Medicine, Nagoya, 466-8550, Japan

    Satoshi Kishida, Yoshifumi Takei & Kenji Kadomatsu

  2. Department of Bioresources Engineering, Okinawa National College of Technology, Okinawa, 905-2192, Japan

    Shinya Ikematsu

Authors
  1. Satoshi Kishida
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  2. Shinya Ikematsu
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  3. Yoshifumi Takei
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  4. Kenji Kadomatsu
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Corresponding author

Correspondence to Satoshi Kishida .

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Editors and Affiliations

  1. , Kean University, Room 213, Library building, Morris Avenue 1000, Union, 07083, New Jersey, USA

    M.A. Hayat

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Kishida, S., Ikematsu, S., Takei, Y., Kadomatsu, K. (2012). Neuroblastoma Patients: Plasma Growth Factor Midkine as a Prognostic Growth Factor. In: Hayat, M. (eds) Neuroblastoma. Pediatric Cancer, vol 1. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2418-1_22

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