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Augmenting the Efficacy of Chemo- and Radio-Therapy by Nutraceuticals: Evidence from Pre-clinical and Clinical Trials

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Nutraceuticals and Cancer

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Abstract

In recent years, dietary agents such as isoflavone genistein, curcumin, indole-3-carbinol (I3C), 3,3’-diindolylmethane (DIM), (-)-epigallocatechin-3-gallate (EGCG), resveratrol, and lycopene have received increased attention as anti-cancer agents. There has been a growing interest in investigating the effects of these dietary agents known as nutraceuticals on the inhibition of cancer cell growth in combination with chemotherapeutics or radiotherapy. The results from pre-clinical in vitro and in vivo experimental studies have demonstrated that the anti-cancer effects of chemotherapeutics and radiotherapy could be enhanced by combination treatment with nutraceuticals. Experimental evidence have also shown that the enhanced anti-cancer effects of nutraceuticals could in part due to deregulation of NF-κB, Akt, MDR, COX-2, AR, MAPK, and apoptotic signaling pathways that are known to play critical roles in cell survival and therapeutic resistance. In this chapter, we are summarizing the current evidence from pre-clinical and clinical trials demonstrating the effects and the molecular mechanisms of nutraceutical intervention in combination treatments, and we believe that this information would allow researcher to have a fresh look at the potential value of nutraceutical in cancer therapy.

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Acknowledgements

The authors’ work cited in this review article was funded by grants from the National Cancer Institute, NIH (5R01CA083695, 5R01CA108535, 5R01CA132794, and 5R01CA131151 awarded to FHS). We also thank Puschelberg and Guido foundations for their generous contribution to support our research.

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Authors and Affiliations

  1. Department of Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA

    Yiwei Li, Dejuan Kong, Aamir Ahmad & Bin Bao

  2. Departments of Pathology and Oncology, Karmanos Cancer Institute, Wayne State University, 740 HWCRC, Detroit, Michigan, 48201, USA

    Fazlul H. Sarkar

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  1. Yiwei Li
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  2. Dejuan Kong
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  3. Aamir Ahmad
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  4. Bin Bao
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  5. Fazlul H. Sarkar
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Correspondence to Fazlul H. Sarkar .

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  1. , Barbara Ann Karmanos Cancer Institute, Department of Pathology, John R Street, Detroit, 48201, USA

    Fazlul H. Sarkar

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© 2012 Springer Science+Business Media B.V.

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Li, Y., Kong, D., Ahmad, A., Bao, B., Sarkar, F.H. (2012). Augmenting the Efficacy of Chemo- and Radio-Therapy by Nutraceuticals: Evidence from Pre-clinical and Clinical Trials. In: Sarkar, F. (eds) Nutraceuticals and Cancer. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2630-7_16

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