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Calcium Signaling in Vascular Smooth Muscle Cells: From Physiology to Pathology

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Calcium Signaling

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 740))

Abstract

Cyclic variations in calcium (Ca2+) concentrations, through a process called excitation-contraction coupling, allow regulation of vascular smooth muscle cells contractility and thus modulation of vascular tone and blood pressure. As a second messenger, Ca2+ also activates signaling cascades leading to transcription factors activation in a process called excitation-transcription coupling. Furthermore, recent evidences indicate an interaction between post-transcriptional regulation by microRNAs (miRNAs) and Ca2+ signaling. All these actors, which are frequently altered in vascular diseases, will be reviewed here.

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Authors and Affiliations

  1. Inserm UMRS 956/ Université Pierre et Marie Curie Paris6, 91 boulevard de l’hôpital, 75013, Paris, France

    Alexandre Marchand, Aniella Abi-Gerges, Youakim Saliba, Elise Merlet & Anne-Marie Lompré

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  1. Alexandre Marchand
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  2. Aniella Abi-Gerges
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  3. Youakim Saliba
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  4. Elise Merlet
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  5. Anne-Marie Lompré
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Correspondence to Anne-Marie Lompré .

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  1. , Department of Clinical Sciences and Educ, Karolinska Institutet, Tulegatan 26, Stockholm, SE-118 83, Sweden

    Md. Shahidul Islam

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Marchand, A., Abi-Gerges, A., Saliba, Y., Merlet, E., Lompré, AM. (2012). Calcium Signaling in Vascular Smooth Muscle Cells: From Physiology to Pathology. In: Islam, M. (eds) Calcium Signaling. Advances in Experimental Medicine and Biology, vol 740. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2888-2_35

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