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Complexes I in the Green Lineage

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A Structural Perspective on Respiratory Complex I

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Abstract

In land plants and green algae, mitochondria and chloroplasts were acquired sequentially through primary endosymbiotic events with a α-proteobacterium and a cyanobacterium, respectively. The inner membrane of the mitochondria harbors the enzyme complexes of the respiratory chain, the largest of them being the rotenone-sensitive NADH:ubiquinone oxidoreductase or complex I. In the thylakoid membrane of the chloroplast, besides the photosynthetic machinery, a light-independent respiratory-chain inherited from cyanobacteria drives electrons from NAD(P)H to oxygen. In most plants and algae, it comprises a homolog of bacterial complex I (NAD(P)H:plastoquinone (PQ) oxidoreductase) and a PQ oxidase (PTOX). This chapter will be thus dedicated to similarities and peculiarities of plant mitochondrial complex I compared to the well studied enzyme in mammals and fungi, as well as to the structure and role of a complex I homolog in chloroplast.

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References

  • Abdrakhmanova A, Zickermann V, Bostina M, Radermacher M, Schagger H, Kerscher S, Brandt U (2004) Subunit composition of mitochondrial complex I from the yeast Yarrowia lipolytica. Biochim Biophys Acta 1658:148–156

    Article  PubMed  CAS  Google Scholar 

  • Abdrakhmanova A, Zwicker K, Kerscher S, Zickermann V, Brandt U (2006) Tight binding of NADPH to the 39-kDa subunit of complex I is not required for catalytic activity but stabilizes the multiprotein complex. Biochim Biophys Acta 1757:1676–1682

    Article  PubMed  CAS  Google Scholar 

  • Angell JE, Lindner DJ, Shapiro PS, Hofmann ER, Kalvakolanu DV (2000) Identification of GRIM-19, a novel cell death-regulatory gene induced by the interferon-beta and retinoic acid combination, using a genetic approach. J Biol Chem 275:33416–33426

    Article  PubMed  CAS  Google Scholar 

  • Antonicka H, Ogilvie I, Taivassalo T, Anitori RP, Haller RG, Vissing J, Kennaway NG, Shoubridge EA (2003) Identification and characterization of a common set of complex I assembly intermediates in mitochondria from patients with complex I deficiency. J Biol Chem 278:43081–43088

    Article  PubMed  CAS  Google Scholar 

  • Arrigoni O, De Tullio MC (2002) Ascorbic acid: much more than just an antioxidant. Biochim Biophys Acta 1569:1–9

    Article  PubMed  CAS  Google Scholar 

  • Arteni AA, Zhang P, Battchikova N, Ogawa T, Aro E-M, Boekema EJ (2006) Structural characterization of NDH-1 complexes of Thermosynechococcus elongatus by single particle electron microscopy. Biochim Biophys Acta 1757:1469–1475

    Article  PubMed  CAS  Google Scholar 

  • Barbieri MR, Larosa V, Nouet C, Remacle C, Hamel PP (2011) A forward genetic screen identifies mutants deficient for mitochondrial complex I assembly in Chlamydomonas reinhardtii. Genetics 188:349–358

    Article  PubMed  CAS  Google Scholar 

  • Bartoli CG, Pastori GM, Foyer CH (2000) Ascorbate biosynthesis in mitochondria is linked to the electron transport chain between complexes III and IV. Plant Physiol 123:335–344

    Article  PubMed  CAS  Google Scholar 

  • Battchikova N, Aro EM (2007) Cyanobacterial NDH-1 complexes: multiplicity in function and subunit composition. Physiol Plant 131:22–32

    Article  PubMed  CAS  Google Scholar 

  • Bennoun P (1982) Evidence for a respiratory chain in the chloroplast. Proc Natl Acad Sci USA 79:4352–4356

    Article  PubMed  CAS  Google Scholar 

  • Brangeon J, Sabar M, Gutierres S, Combettes B, Bove J, Gendy C, Chetrit P, Des Francs-Small CC, Pla M, Vedel F, De Paepe R (2000) Defective splicing of the first nad4 intron is associated with lack of several complex I subunits in the Nicotiana sylvestris NMS1 nuclear mutant. Plant J 21:269–280

    Article  PubMed  CAS  Google Scholar 

  • Bridges HR, Fearnley IM, Hirst J (2010) The subunit composition of mitochondrial NADH:ubiquinone oxidoreductase (complex I) from Pichia pastoris. Mol Cell Proteomics 9:2318–2326

    Article  PubMed  CAS  Google Scholar 

  • Bultema JB, Braun HP, Boekema EJ, Kouril R (2009) Megacomplex organization of the oxidative phosphorylation system by structural analysis of respiratory supercomplexes from potato. Biochim Biophys Acta 1787:60–67

    Article  PubMed  CAS  Google Scholar 

  • Burrows PA, Sazanov LA, Svab Z, Maliga P, Nixon PJ (1998) Identification of a functional respiratory complex in chloroplasts through analysis of tobacco mutants containing disrupted plastid ndh genes. EMBO J 17:868–876

    Article  PubMed  CAS  Google Scholar 

  • Bych K, Kerscher S, Netz DJ, Pierik AJ, Zwicker K, Huynen MA, Lill R, Brandt U, Balk J (2008) The iron-sulphur protein Ind1 is required for effective complex I assembly. EMBO J 27:1736–1746

    Article  PubMed  CAS  Google Scholar 

  • Calvo SE, Tucker EJ, Compton AG, Kirby DM, Crawford G, Burtt NP, Rivas M, Guiducci C, Bruno DL, Goldberger OA, Redman MC, Wiltshire E, Wilson CJ, Altshuler D, Gabriel SB, Daly MJ, Thorburn DR, Mootha VK (2010) High-throughput, pooled sequencing identifies mutations in NUBPL and FOXRED1 in human complex I deficiency. Nat Genet. doi:10.1038/ng.659

  • Cardol P (2011) Mitochondrial NADH:ubiquinone oxidoreductase (complex I) in eukaryotes: a highly-conserved subunit composition highlighted by mining of protein databases. Biochim Biophys Acta. doi:10.1016/j.bbabio.2011.06.015

  • Cardol P, Matagne RF, Remacle C (2002) Impact of mutations affecting ND mitochondria-encoded subunits on the activity and assembly of complex I in Chlamydomonas. Implication for the structural organization of the enzyme. J Mol Biol 319:1211–1221

    Article  PubMed  CAS  Google Scholar 

  • Cardol P, Gloire G, Havaux M, Remacle C, Matagne R, Franck F (2003) Photosynthesis and state transitions in mitochondrial mutants of Chlamydomonas reinhardtii affected in respiration. Plant Physiol 133:2010–2020

    Article  PubMed  CAS  Google Scholar 

  • Cardol P, Vanrobaeys F, Devreese B, Van Beeumen J, Matagne RF, Remacle C (2004) Higher plant-like subunit composition of mitochondrial complex I from Chlamydomonas reinhardtii: 31 conserved components among eukaryotes. Biochim Biophys Acta 1658:212–224

    Article  PubMed  CAS  Google Scholar 

  • Cardol P, Gonzalez-Halphen D, Reyes-Prieto A, Baurain D, Matagne RF, Remacle C (2005) The mitochondrial oxidative phosphorylation proteome of Chlamydomonas reinhardtii deduced from the genome sequencing project. Plant Physiol 137:447–459

    Article  PubMed  CAS  Google Scholar 

  • Cardol P, Lapaille M, Minet P, Franck F, Matagne RF, Remacle C (2006) ND3 and ND4L subunits of mitochondrial complex I, both nucleus encoded in Chlamydomonas reinhardtii, are required for activity and assembly of the enzyme. Eukaryot Cell 5:1460–1467

    Article  PubMed  CAS  Google Scholar 

  • Cardol P, Boutaffala L, Memmi S, Devreese B, Matagne RF, Remacle C (2008) In Chlamydomonas, the loss of ND5 subunit prevents the assembly of whole mitochondrial complex I and leads to the formation of a low abundant 700 kDa subcomplex. Biochim Biophys Acta 1777:388–396

    Article  PubMed  CAS  Google Scholar 

  • Cardol P, De Paepe R, Franck F, Forti G, Finazzi G (2010) The onset of NPQ and Deltamu(H)  +  upon illumination of tobacco plants studied through the influence of mitochondrial electron transport. Biochim Biophys Acta 1797:177–188

    Article  PubMed  CAS  Google Scholar 

  • Carol P, Stevenson D, Bisanz C, Breitenbach J, Sandmann G, Mache R, Coupland G, Kuntz M (1999) Mutations in the Arabidopsis gene IMMUTANS cause a variegated phenotype by inactivating a chloroplast terminal oxidase associated with phytoene desaturation. Plant Cell 11:57–68

    Article  PubMed  CAS  Google Scholar 

  • Carroll J, Shannon RJ, Fearnley IM, Walker JE, Hirst J (2002) Definition of the nuclear encoded protein composition of bovine heart mitochondrial complex I. Identification of two new subunits. J Biol Chem 277:50311–50317

    Article  PubMed  CAS  Google Scholar 

  • Carroll J, Fearnley IM, Shannon RJ, Hirst J, Walker JE (2003) Analysis of the subunit composition of complex I from bovine heart mitochondria. Mol Cell Proteomics 2:117–126

    Article  PubMed  CAS  Google Scholar 

  • Carroll J, Fearnley IM, Skehel JM, Runswick MJ, Shannon RJ, Hirst J, Walker JE (2005) The post-translational modifications of the nuclear encoded subunits of complex I from bovine heart mitochondria. Mol Cell Proteomics 4:693–699

    Article  PubMed  CAS  Google Scholar 

  • Carroll J, Fearnley IM, Skehel JM, Shannon RJ, Hirst J, Walker JE (2006) Bovine complex I is a complex of 45 different subunits. J Biol Chem 281:32724–32727

    Article  PubMed  CAS  Google Scholar 

  • Combettes B, Grienenberger JM (1999) Analysis of wheat mitochondrial complex I purified by a one-step immunoaffinity chromatography. Biochimie 81:645–653

    Article  PubMed  CAS  Google Scholar 

  • Cronan JE, Fearnley IM, Walker JE (2005) Mammalian mitochondria contain a soluble acyl carrier protein. FEBS Lett 579:4892–4896

    Article  PubMed  CAS  Google Scholar 

  • de Longevialle AF, Meyer EH, Andres C, Taylor NL, Lurin C, Millar AH, Small ID (2007) The pentatricopeptide repeat gene OTP43 is required for trans-splicing of the mitochondrial nad1 Intron 1 in Arabidopsis thaliana. Plant Cell 19:3256–3265

    Article  PubMed  CAS  Google Scholar 

  • Derelle E, Ferraz C, Rombauts S, Rouze P, Worden AZ, Robbens S, Partensky F, Degroeve S, Echeynie S, Cooke R, Saeys Y, Wuyts J, Jabbari K, Bowler C, Panaud O, Piegu B, Ball SG, Ral JP, Bouget FY, Piganeau G, De Baets B, Picard A, Delseny M, Demaille J, Van de Peer Y, Moreau H (2006) Genome analysis of the smallest free-living eukaryote Ostreococcus tauri unveils many unique features. Proc Natl Acad Sci USA 103:11647–11652

    Article  PubMed  CAS  Google Scholar 

  • Desplats C, Mus F, Cuiné S, Billon E, Cournarc L, Peltier G (2009) Characterization of Nda2, a plastoquinone-reducing type II NAD(P)H dehydrogenase in Chlamydomonas chloroplasts. J Biol Chem 284:4148–4157

    Article  PubMed  CAS  Google Scholar 

  • Dieteren CE, Willems PH, Vogel RO, Swarts HG, Fransen J, Roepman R, Crienen G, Smeitink JA, Nijtmans LG, Koopman WJ (2008) Subunits of mitochondrial complex I exist as part of matrix- and membrane-associated subcomplexes in living cells. J Biol Chem 283:34753–34761

    Article  PubMed  CAS  Google Scholar 

  • Dobrynin K, Abdrakhmanova A, Richers S, Hunte C, Kerscher S, Brandt U (2010) Characterization of two different acyl carrier proteins in complex I from Yarrowia lipolytica. Biochim Biophys Acta 1797:152–159

    Article  PubMed  CAS  Google Scholar 

  • Dunning CJ, McKenzie M, Sugiana C, Lazarou M, Silke J, Connelly A, Fletcher JM, Kirby DM, Thorburn DR, Ryan MT (2007) Human CIA30 is involved in the early assembly of mitochondrial complex I and mutations in its gene cause disease. EMBO J 26:3227–3237

    Article  PubMed  CAS  Google Scholar 

  • Dutilleul C, Driscoll S, Cornic G, De Paepe R, Foyer CH, Noctor G (2003a) Functional mitochondrial complex I is required by tobacco leaves for optimal photosynthetic performance in photorespiratory conditions and during transients. Plant Physiol 131:264–275

    Article  PubMed  CAS  Google Scholar 

  • Dutilleul C, Garmier M, Noctor G, Mathieu C, Chetrit P, Foyer CH, de Paepe R (2003b) Leaf mitochondria modulate whole cell redox homeostasis, set antioxidant capacity, and determine stress resistance through altered signaling and diurnal regulation. Plant Cell 15:1212–1226

    Article  PubMed  CAS  Google Scholar 

  • Dutilleul C, Lelarge C, Prioul JL, De Paepe R, Foyer CH, Noctor G (2005) Mitochondria-driven changes in leaf NAD status exert a crucial influence on the control of nitrate assimilation and the integration of carbon and nitrogen metabolism. Plant Physiol 139:64–78

    Article  PubMed  CAS  Google Scholar 

  • Eubel H, Heinemeyer J, Braun HP (2004) Identification and characterization of respirasomes in potato mitochondria. Plant Physiol 134:1450–1459

    Article  PubMed  CAS  Google Scholar 

  • Feng D, Witkowski A, Smith S (2009) Down-regulation of mitochondrial acyl carrier protein in mammalian cells compromises protein lipoylation and respiratory complex I and results in cell death. J Biol Chem 284:11436–11445

    Article  PubMed  CAS  Google Scholar 

  • Friedrich T, Steinmüller K, Weiss H (1995) The proton-pumping respiratory complex I of bacteria and mitochondria and its homologue in chloroplasts. FEBS Lett 367:107–111

    Article  PubMed  CAS  Google Scholar 

  • Friedrich T, Abelmann A, Brors B, Guenebaut V, Kintscher L, Leonard K, Rasmussen T, Scheide D, Schlitt A, Schulte U, Weiss H (1998) Redox components and structure of the respiratory NADH:ubiquinone oxidoreductase (complex I). Biochim Biophys Acta 1365:215–219

    Article  PubMed  CAS  Google Scholar 

  • Gabaldon T, Rainey D, Huynen MA (2005) Tracing the evolution of a large protein complex in the eukaryotes, NADH:ubiquinone oxidoreductase (complex I). J Mol Biol 348:857–870

    Article  PubMed  CAS  Google Scholar 

  • Galle A, Florez-Sarasa I, Thameur A, de Paepe R, Flexas J, Ribas-Carbo M (2010) Effects of drought stress and subsequent rewatering on photosynthetic and respiratory pathways in Nicotiana sylvestris wild type and the mitochondrial complex I-deficient CMSII mutant. J Exp Bot 61:765–775

    Article  PubMed  CAS  Google Scholar 

  • Gao L, Yi X, Yang Y-X, Su Y-J, Wang T (2009) Complete chloroplast genome sequence of a tree fern Alsophila spinulosa: insights into evolutionary changes in fern chloroplast genomes. BMC Evol Biol 9:130

    Article  PubMed  CAS  Google Scholar 

  • Gawryluk RM, Gray MW (2010) Evidence for an early evolutionary emergence of gamma-type carbonic anhydrases as components of mitochondrial respiratory complex I. BMC Evol Biol 10:176

    Article  PubMed  CAS  Google Scholar 

  • Gutierres S, Sabar M, Lelandais C, Chetrit P, Diolez P, Degand H, Boutry M, Vedel F, de Kouchkovsky Y, De Paepe R (1997) Lack of mitochondrial and nuclear-encoded subunits of complex I and alteration of the respiratory chain in Nicotiana sylvestris mitochondrial deletion mutants. Proc Natl Acad Sci USA 94:3436–3441

    Article  PubMed  CAS  Google Scholar 

  • Gutierres S, Combettes B, De Paepe R, Mirande M, Lelandais C, Vedel F, Chetrit P (1999) In the Nicotiana sylvestris CMSII mutant, a recombination-mediated change 5′ to the first exon of the mitochondrial nad1 gene is associated with lack of the NADH:ubiquinone oxidoreductase (complex I) NAD1 subunit. Eur J Biochem 261:361–370

    Article  PubMed  CAS  Google Scholar 

  • Heazlewood JL, Howell KA, Millar AH (2003) Mitochondrial complex I from Arabidopsis and rice: orthologs of mammalian and fungal components coupled with plant-specific subunits. Biochim Biophys Acta 1604:159–169

    Article  PubMed  CAS  Google Scholar 

  • Herz U, Schroder W, Liddell A, Leaver CJ, Brennicke A, Grohmann L (1994) Purification of the NADH:ubiquinone oxidoreductase (complex I) of the respiratory chain from the inner mitochondrial membrane of Solanum tuberosum. J Biol Chem 269:2263–2269

    PubMed  CAS  Google Scholar 

  • Hinttala R, Uusimaa J, Remes AM, Rantala H, Hassinen IE, Majamaa K (2005) Sequence analysis of nuclear genes encoding functionally important complex I subunits in children with encephalomyopathy. J Mol Med 83:786–794

    Article  PubMed  CAS  Google Scholar 

  • Hirst J, Carroll J, Fearnley IM, Shannon RJ, Walker JE (2003) The nuclear encoded subunits of complex I from bovine heart mitochondria. Biochim Biophys Acta 1604:135–150

    Article  PubMed  CAS  Google Scholar 

  • Horvath EM, Peter SO, Joet T, Rumeau D, Cournac L, Horvath GV, Kavanagh TA, Schafer C, Peltier G, Medgyesy P (2000) Targeted inactivation of the plastid ndhB gene in tobacco results in an enhanced sensitivity of photosynthesis to moderate stomatal closure. Plant Physiol 123:1337–1350

    Article  PubMed  CAS  Google Scholar 

  • Huynen MA, de Hollander M, Szklarczyk R (2009) Mitochondrial proteome evolution and genetic disease. Biochim Biophys Acta 1792:1122–1129

    PubMed  CAS  Google Scholar 

  • Ifuku K, Endo T, Shikanai T, Aro EM (2011) Structure of the chloroplast NADH dehydrogenase-like complex: nomenclature for nuclear-encoded subunits. Plant Cell Physiol 52:1560–1568

    Article  PubMed  CAS  Google Scholar 

  • Ishida S, Takabayashi A, Ishikawa N, Hano Y, Endo T, Sato F (2009) A novel nuclear-encoded protein, NDH-dependent cyclic electron flow 5, is essential for the accumulation of chloroplast NAD(P)H dehydrogenase complexes. Plant Cell Physiol 50:383–393

    Article  PubMed  CAS  Google Scholar 

  • Ishihara S, Takabayashi A, Ido K, Endo T, Ifuku K, Sato F (2007) Distinct functions for the two PsbP-like proteins PPL1 and PPL2 in the chloroplast thylakoid lumen of Arabidopsis. Plant Physiol 145:668–679

    Article  PubMed  CAS  Google Scholar 

  • Ishikawa N, Takabayashi A, Ishida S, Hano Y, Endo T, Sato F (2008) NDF6: a thylakoid protein specific to terrestrial plants is essential for activity of chloroplastic NAD(P)H dehydrogenase in Arabidopsis. Plant Cell Physiol 49:1066–1073

    Article  PubMed  CAS  Google Scholar 

  • Ishitani M, Xiong L, Stevenson B, Zhu JK (1997) Genetic analysis of osmotic and cold stress signal transduction in Arabidopsis: interactions and convergence of abscisic acid-dependent and abscisic acid-independent pathways. Plant Cell 9:1935–1949

    Article  PubMed  CAS  Google Scholar 

  • Jans F, Mignolet M, Hoyoux PA, Cardol P, Ghysels B, Cuiné S, Cournac L, Peltier G, Remacle C, Franck F (2008) A type II NAD(P)H dehydrogenase mediates light-independent plastoquinone reduction in the chloroplast of Chlamydomonas. Proc Natl Acad Sci USA 105:20546–20551

    Article  PubMed  CAS  Google Scholar 

  • Johnson GN (2011) Reprint of: physiology of PSI cyclic electron transport in higher plants. Biochim Biophys Acta 1807:906–911

    Article  PubMed  CAS  Google Scholar 

  • Jonietz C, Forner J, Holzle A, Thuss S, Binder S (2010) RNA PROCESSING FACTOR2 is required for 5′ end processing of nad9 and cox3 mRNAs in mitochondria of Arabidopsis thaliana. Plant Cell 22:443–453

    Article  PubMed  CAS  Google Scholar 

  • Juszczuk IM, Rychter AM (2009) BN-PAGE analysis of the respiratory chain complexes in mitochondria of cucumber MSC16 mutant. Plant Physiol Biochem 47:397–406

    Article  PubMed  CAS  Google Scholar 

  • Karpova OV, Newton KJ (1999) A partially assembled complex I in ND4-deficient mitochondria of maize. Plant J 17:511–521

    Article  CAS  Google Scholar 

  • Karpova OV, Kuzmin EV, Elthon TE, Newton KJ (2002) Differential expression of alternative oxidase genes in maize mitochondrial mutants. Plant Cell 14:3271–3284

    Article  PubMed  CAS  Google Scholar 

  • Keeling PJ, Burger G, Durnford DG, Lang BF, Lee RW, Pearlman RE, Roger AJ, Gray MW (2005) The tree of eukaryotes. Trends Ecol Evol 20:670–676

    Article  PubMed  Google Scholar 

  • Klodmann J, Sunderhaus S, Nimtz M, Jansch L, Braun HP (2010) Internal architecture of mitochondrial complex I from Arabidopsis thaliana. Plant Cell 22:797–810

    Article  PubMed  CAS  Google Scholar 

  • Kofer W, Koop HU, Wanner G, Steinmüller K (1998) Mutagenesis of the genes encoding subunits A, C, H, I, J and K of the plastid NAD(P)H-plastoquinone-oxidoreductase in tobacco by polyethylene glycol-mediated plastome transformation. Mol Gen Genet 258:166–173

    Article  PubMed  CAS  Google Scholar 

  • Krause F, Reifschneider NH, Vocke D, Seelert H, Rexroth S, Dencher NA (2004) “Respirasome”-like supercomplexes in green leaf mitochondria of spinach. J Biol Chem 279:48369–48375

    Article  PubMed  CAS  Google Scholar 

  • Kuffner R, Rohr A, Schmiede A, Krull C, Schulte U (1998) Involvement of two novel chaperones in the assembly of mitochondrial NADH:Ubiquinone oxidoreductase (complex I). J Mol Biol 283:409–417

    Article  PubMed  CAS  Google Scholar 

  • Lazarou M, Thorburn DR, Ryan MT, McKenzie M (2009) Assembly of mitochondrial complex I and defects in disease. Biochim Biophys Acta 1793:78–88

    Article  PubMed  CAS  Google Scholar 

  • Lee BH, Lee H, Xiong L, Zhu JK (2002) A mitochondrial complex I defect impairs cold-regulated nuclear gene expression. Plant Cell 14:1235–1251

    Article  PubMed  CAS  Google Scholar 

  • Lemieux C, Otis C, Turmel M (2000) Ancestral chloroplast genome in Mesostigma viride reveals an early branch of green plant evolution. Nature 403:649–652

    Article  PubMed  CAS  Google Scholar 

  • Lennon AM, Prommeenate P, Nixon PJ (2003) Location, expression and orientation of the putative chlororespiratory enzymes, Ndh and IMMUTANS, in higher-plant plastids. Planta 218:254–260

    Article  PubMed  CAS  Google Scholar 

  • Leterme S, Boutry M (1993) Purification and preliminary characterization of mitochondrial complex I (NADH: ubiquinone reductase) from broad bean (Vicia faba L.). Plant Physiol 102:435–443

    Article  PubMed  CAS  Google Scholar 

  • Liu YJ, Norberg FE, Szilagyi A, De Paepe R, Akerlund HE, Rasmusson AG (2008) The mitochondrial external NADPH dehydrogenase modulates the leaf NADPH/NADP  +  ratio in transgenic Nicotiana sylvestris. Plant Cell Physiol 49:251–263

    Article  PubMed  CAS  Google Scholar 

  • Majeran W, Zybailov B, Ytterberg AJ, Dunsmore J, Sun Q, van Wijk KJ (2008) Consequences of C4 differentiation for chloroplast membrane proteomes in maize mesophyll and bundle sheath cells. Mol Cell Proteomics 7:1609–1638

    Article  PubMed  CAS  Google Scholar 

  • Marienfeld JR, Newton KJ (1994) The maize NCS2 abnormal growth mutant has a chimeric nad4-nad7 mitochondrial gene and is associated with reduced complex I function. Genetics 138:855–863

    PubMed  CAS  Google Scholar 

  • Marques I, Duarte M, Assuncao J, Ushakova AV, Videira A (2005) Composition of complex I from Neurospora crassa and disruption of two “accessory” subunits. Biochim Biophys Acta 1707:211–220

    Article  PubMed  CAS  Google Scholar 

  • Martin V, Villarreal F, Miras I, Navaza A, Haouz A, Gonzalez-Lebrero RM, Kaufman SB, Zabaleta E (2009) Recombinant plant gamma carbonic anhydrase homotrimers bind inorganic carbon. FEBS Lett 583:3425–3430

    Article  PubMed  CAS  Google Scholar 

  • Maul JE, Lilly JW, Cui L, dePamphilis CW, Miller W, Harris EH, Stern DB (2002) The Chlamydomonas reinhardtii plastid chromosome: islands of genes in a sea of repeats. Plant Cell 14:2659–2679

    Article  PubMed  CAS  Google Scholar 

  • McKenzie M, Ryan MT (2010) Assembly factors of human mitochondrial complex I and their defects in disease. IUBMB Life 62:497–502

    Article  PubMed  CAS  Google Scholar 

  • Merchant SS, Prochnik SE, Vallon O, Harris EH, Karpowicz SJ, Witman GB, Terry A, Salamov A, Fritz-Laylin LK, Marechal-Drouard L, Marshall WF, Qu LH, Nelson DR, Sanderfoot AA, Spalding MH, Kapitonov VV, Ren Q, Ferris P, Lindquist E, Shapiro H, Lucas SM, Grimwood J, Schmutz J, Cardol P, Cerutti H, Chanfreau G, Chen CL, Cognat V, Croft MT, Dent R, Dutcher S, Fernandez E, Fukuzawa H, Gonzalez-Ballester D, Gonzalez-Halphen D, Hallmann A, Hanikenne M, Hippler M, Inwood W, Jabbari K, Kalanon M, Kuras R, Lefebvre PA, Lemaire SD, Lobanov AV, Lohr M, Manuell A, Meier I, Mets L, Mittag M, Mittelmeier T, Moroney JV, Moseley J, Napoli C, Nedelcu AM, Niyogi K, Novoselov SV, Paulsen IT, Pazour G, Purton S, Ral JP, Riano-Pachon DM, Riekhof W, Rymarquis L, Schroda M, Stern D, Umen J, Willows R, Wilson N, Zimmer SL, Allmer J, Balk J, Bisova K, Chen CJ, Elias M, Gendler K, Hauser C, Lamb MR, Ledford H, Long JC, Minagawa J, Page MD, Pan J, Pootakham W, Roje S, Rose A, Stahlberg E, Terauchi AM, Yang P, Ball S, Bowler C, Dieckmann CL, Gladyshev VN, Green P, Jorgensen R, Mayfield S, Mueller-Roeber B, Rajamani S, Sayre RT, Brokstein P, Dubchak I, Goodstein D, Hornick L, Huang YW, Jhaveri J, Luo Y, Martinez D, Ngau WC, Otillar B, Poliakov A, Porter A, Szajkowski L, Werner G, Zhou K, Grigoriev IV, Rokhsar DS, Grossman AR (2007) The Chlamydomonas genome reveals the evolution of key animal and plant functions. Science 318:245–250

    Article  PubMed  CAS  Google Scholar 

  • Meyer EH, Heazlewood JL, Millar AH (2007) Mitochondrial acyl carrier proteins in Arabidopsis thaliana are predominantly soluble matrix proteins and none can be confirmed as subunits of respiratory complex I. Plant Mol Biol 64:319–327

    Article  PubMed  CAS  Google Scholar 

  • Meyer EH, Taylor NL, Millar AH (2008) Resolving and identifying protein components of plant mitochondrial respiratory complexes using three dimensions of gel electrophoresis. J Proteome Res 7:786–794

    Article  PubMed  CAS  Google Scholar 

  • Meyer EH, Tomaz T, Carroll AJ, Estavillo G, Delannoy E, Tanz SK, Small ID, Pogson BJ, Millar AH (2009) Remodeled respiration in ndufs4 with low phosphorylation efficiency suppresses Arabidopsis germination and growth and alters control of metabolism at night. Plant Physiol 151:603–619

    Article  PubMed  CAS  Google Scholar 

  • Millar AH, Mittova V, Kiddle G, Heazlewood JL, Bartoli CG, Theodoulou FL, Foyer CH (2003) Control of ascorbate synthesis by respiration and its implications for stress responses. Plant Physiol 133:443–447

    Article  PubMed  CAS  Google Scholar 

  • Morgner N, Zickermann V, Kerscher S, Wittig I, Abdrakhmanova A, Barth HD, Brutschy B, Brandt U (2008) Subunit mass fingerprinting of mitochondrial complex I. Biochim Biophys Acta 1777:1384–1391

    Article  PubMed  CAS  Google Scholar 

  • Munshi MK, Kobayashi Y, Shikanai T (2005) Identification of a novel protein, CRR7, required for the stabilization of the chloroplast NAD(P)H dehydrogenase complex in Arabidopsis. Plant J 44:1036–1044

    Article  CAS  Google Scholar 

  • Munshi MK, Kobayashi Y, Shikanai T (2006) Chlororespiratory reduction 6 is a novel factor required for accumulation of the chloroplast NAD(P)H dehydrogenase complex in Arabidopsis. Plant Physiol 141:737–744

    Article  PubMed  CAS  Google Scholar 

  • Muraoka R, Okuda K, Kobayashi Y, Shikanai T (2006) A eukaryotic factor required for accumulation of the chloroplast NAD(P)H dehydrogenase complex in Arabidopsis. Plant Physiol 142:1683–1689

    Article  PubMed  CAS  Google Scholar 

  • Nakagawa N, Sakurai N (2006) A mutation in At-nMat1a, which encodes a nuclear gene having high similarity to group II intron maturase, causes impaired splicing of mitochondrial NAD4 transcript and altered carbon metabolism in Arabidopsis thaliana. Plant Cell Physiol 47:772–783

    Article  PubMed  CAS  Google Scholar 

  • Nashilevitz S, Melamed-Bessudo C, Izkovich Y, Rogachev I, Osorio S, Itkin M, Adato A, Pankratov I, Hirschberg J, Fernie AR, Wolf S, Usadel B, Levy AA, Rumeau D, Aharoni A (2010) An orange ripening mutant links plastid NAD(P)H dehydrogenase complex activity to central and specialized metabolism during tomato fruit maturation. Plant Cell 22:1977–1997

    Article  PubMed  CAS  Google Scholar 

  • Ogawa T, Mi H (2007) Cyanobacterial NADPH dehydrogenase complexes. Photosynth Res 93:69–77

    Article  PubMed  CAS  Google Scholar 

  • Ohyama K, Fukuzawa H, Kohchi T, Shirai H, Sano T, Sano S, Umesono K, Shiki Y, Takeuchi M, Chang Z, Aota S-i, Inokuchi H, Ozeki H (1986) Chloroplast gene organization deduced from complete sequence of liverwort Marchantia polymorpha chloroplast DNA. Nature 322:572–574

    Article  CAS  Google Scholar 

  • Ostergaard J, Persiau G, Davey MW, Bauw G, Van Montagu M (1997) Isolation of a cDNA coding for L-galactono-gamma-lactone dehydrogenase, an enzyme involved in the biosynthesis of ascorbic acid in plants. Purification, characterization, cDNA cloning, and expression in yeast. J Biol Chem 272:30009–30016

    Article  PubMed  CAS  Google Scholar 

  • Pagliarini DJ, Calvo SE, Chang B, Sheth SA, Vafai SB, Ong SE, Walford GA, Sugiana C, Boneh A, Chen WK, Hill DE, Vidal M, Evans JG, Thorburn DR, Carr SA, Mootha VK (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134:112–123

    Article  PubMed  CAS  Google Scholar 

  • Palenik B, Grimwood J, Aerts A, Rouze P, Salamov A, Putnam N, Dupont C, Jorgensen R, Derelle E, Rombauts S, Zhou K, Otillar R, Merchant SS, Podell S, Gaasterland T, Napoli C, Gendler K, Manuell A, Tai V, Vallon O, Piganeau G, Jancek S, Heijde M, Jabbari K, Bowler C, Lohr M, Robbens S, Werner G, Dubchak I, Pazour GJ, Ren Q, Paulsen I, Delwiche C, Schmutz J, Rokhsar D, Van de Peer Y, Moreau H, Grigoriev IV (2007) The tiny eukaryote Ostreococcus provides genomic insights into the paradox of plankton speciation. Proc Natl Acad Sci USA 104:7705–7710

    Article  PubMed  CAS  Google Scholar 

  • Parisi G, Perales M, Fornasari MS, Colaneri A, Gonzalez-Schain N, Gomez-Casati D, Zimmermann S, Brennicke A, Araya A, Ferry JG, Echave J, Zabaleta E (2004) Gamma carbonic anhydrases in plant mitochondria. Plant Mol Biol 55:193–207

    Article  PubMed  CAS  Google Scholar 

  • Peltier G, Tolleter D, Billon E, Cournac L (2010) Auxiliary electron transport pathways in chloroplasts of microalgae. Photosynth Res. doi:10.1007/s11120-010-9575-3

  • Peng L, Shimizu H, Shikanai T (2008) The chloroplast NAD(P)H dehydrogenase complex interacts with photosystem I in Arabidopsis. J Biol Chem 283:34873–34879

    Article  PubMed  CAS  Google Scholar 

  • Peng L, Fukao Y, Fujiwara M, Takami T, Shikanai T (2009) Efficient operation of NAD(P)H dehydrogenase requires supercomplex formation with photosystem I via minor LHCI in Arabidopsis. Plant Cell 21:3623–3640

    Article  PubMed  CAS  Google Scholar 

  • Peng L, Cai W, Shikanai T (2010) Chloroplast stromal proteins, CRR6 and CRR7, are required for assembly of the NAD(P)H dehydrogenase subcomplex A in Arabidopsis. Plant J 63:203–211

    Article  PubMed  CAS  Google Scholar 

  • Perales M, Parisi G, Fornasari MS, Colaneri A, Villarreal F, Gonzalez-Schain N, Echave J, Gomez-Casati D, Braun HP, Araya A, Zabaleta E (2004) Gamma carbonic anhydrase like complex interact with plant mitochondrial complex I. Plant Mol Biol 56:947–957

    Article  PubMed  CAS  Google Scholar 

  • Perales M, Eubel H, Heinemeyer J, Colaneri A, Zabaleta E, Braun HP (2005) Disruption of a nuclear gene encoding a mitochondrial gamma carbonic anhydrase reduces complex I and supercomplex I  +  III2 levels and alters mitochondrial physiology in Arabidopsis. J Mol Biol 350:263–277

    Article  PubMed  CAS  Google Scholar 

  • Peters K, Dudkina NV, Jansch L, Braun HP, Boekema EJ (2008) A structural investigation of complex I and I  +  III2 supercomplex from Zea mays at 11–13 A resolution: assignment of the carbonic anhydrase domain and evidence for structural heterogeneity within complex I. Biochim Biophys Acta 1777:84–93

    Article  PubMed  CAS  Google Scholar 

  • Pineau B, Mathieu C, Gerard-Hirne C, De Paepe R, Chetrit P (2005) Targeting the NAD7 subunit to mitochondria restores a functional complex I and a wild type phenotype in the Nicotiana sylvestris CMS II mutant lacking nad7. J Biol Chem 280:25994–26001

    Article  PubMed  CAS  Google Scholar 

  • Pineau B, Layoune O, Danon A, De Paepe R (2008) L-galactono-1,4-lactone dehydrogenase is required for the accumulation of plant respiratory complex I. J Biol Chem 283:32500–32505

    Article  PubMed  CAS  Google Scholar 

  • Pla M, Mathieu C, De Paepe R, Chetrit P, Vedel F (1995) Deletion of the last two exons of the mitochondrial nad7 gene results in lack of the NAD7 polypeptide in a Nicotiana sylvestris CMS mutant. Mol Gen Genet 248:79–88

    Article  PubMed  CAS  Google Scholar 

  • Remacle C, Baurain D, Cardol P, Matagne RF (2001a) Mutants of Chlamydomonas reinhardtii deficient in mitochondrial complex I: characterization of two mutations affecting the nd1 coding sequence. Genetics 158:1051–1060

    PubMed  CAS  Google Scholar 

  • Remacle C, Duby F, Cardol P, Matagne RF (2001b) Mutations inactivating mitochondrial genes in Chlamydomonas reinhardtii. Biochem Soc Trans 29:442–446

    Article  PubMed  CAS  Google Scholar 

  • Remacle C, Cardol P, Coosemans N, Gaisne M, Bonnefoy N (2006) High-efficiency biolistic transformation of Chlamydomonas mitochondria can be used to insert mutations in complex I genes. Proc Natl Acad Sci USA 103:4771–4776

    Article  PubMed  CAS  Google Scholar 

  • Remacle C, Barbieri MR, Cardol P, Hamel PP (2008) Eukaryotic complex I: functional diversity and experimental systems to unravel the assembly process. Mol Genet Genomics 280:93–110

    Article  PubMed  CAS  Google Scholar 

  • Robbens S, Derelle E, Ferraz C, Wuyts J, Moreau H, Van de Peer Y (2007) The complete chloroplast and mitochondrial DNA sequence of Ostreococcus tauri: organelle genomes of the smallest eukaryote are examples of compaction. Mol Biol Evol 24:956–968

    Article  PubMed  CAS  Google Scholar 

  • Roussell DL, Thompson DL, Pallardy SG, Miles D, Newton KJ (1991) Chloroplast structure and function is altered in the NCS2 maize mitochondrial mutant. Plant Physiol 96:232–238

    Article  PubMed  CAS  Google Scholar 

  • Rumeau D, Becuwe-Linka N, Beyly A, Louwagie M, Garin J, Peltier G (2005) New subunits NDH-M, -N, and -O, encoded by nuclear genes, are essential for plastid Ndh complex functioning in higher plants. Plant Cell 17:219–232

    Article  PubMed  CAS  Google Scholar 

  • Rumeau D, Peltier G, Cournac L (2007) Chlororespiration and cyclic electron flow around PSI during photosynthesis and plant stress response. Plant Cell Environ 30:1041–1051

    Article  PubMed  CAS  Google Scholar 

  • Saada A, Vogel RO, Hoefs SJ, van den Brand MA, Wessels HJ, Willems PH, Venselaar H, Shaag A, Barghuti F, Reish O, Shohat M, Huynen MA, Smeitink JA, van den Heuvel LP, Nijtmans LG (2009) Mutations in NDUFAF3 (C3ORF60), encoding an NDUFAF4 (C6ORF66)-interacting complex I assembly protein, cause fatal neonatal mitochondrial disease. Am J Hum Genet 84:718–727

    Article  PubMed  CAS  Google Scholar 

  • Sabar M, De Paepe R, de Kouchkovsky Y (2000) Complex I impairment, respiratory compensations, and photosynthetic decrease in nuclear and mitochondrial male sterile mutants of Nicotiana sylvestris. Plant Physiol 124:1239–1250

    Article  PubMed  CAS  Google Scholar 

  • Sazanov LA, Burrows P, Nixon PJ (1996) Detection and characterization of a complex I-like NADH-specific dehydrogenase from pea thylakoids. Biochem Soc Trans 24:739–743

    PubMed  CAS  Google Scholar 

  • Sazanov LA, Burrows PA, Nixon PJ (1998) The chloroplast Ndh complex mediates the dark reduction of the plastoquinone pool in response to heat stress in tobacco leaves. FEBS Lett 429:115–118

    Article  PubMed  CAS  Google Scholar 

  • Schilling B, Bharath MMS, Row RH, Murray J, Cusack MP, Capaldi RA, Freed CR, Prasad KN, Andersen JK, Gibson BW (2005) Rapid purification and mass spectrometric characterization of mitochondrial NADH dehydrogenase (complex I) from rodent brain and a dopaminergic neuronal cell line. Mol Cell Proteomics 4:84–96

    PubMed  CAS  Google Scholar 

  • Schneider R, Massow M, Lisowsky T, Weiss H (1995) Different respiratory-defective phenotypes of Neurospora crassa and Saccharomyces cerevisiae after inactivation of the gene encoding the mitochondrial acyl carrier protein. Curr Genet 29:10–17

    Article  PubMed  CAS  Google Scholar 

  • Sheftel AD, Stehling O, Pierik AJ, Netz DJ, Kerscher S, Elsasser HP, Wittig I, Balk J, Brandt U, Lill R (2009) Human ind1, an iron-sulfur cluster assembly factor for respiratory complex I. Mol Cell Biol 29:6059–6073

    Article  PubMed  CAS  Google Scholar 

  • Shikanai T (2007) Cyclic electron transport around photosystem I: genetic approaches. Annu Rev Plant Biol 58:199–217

    Article  PubMed  CAS  Google Scholar 

  • Shikanai T, Endo T, Hashimoto T, Yamada Y, Asada K, Yokota A (1998) Directed disruption of the tobacco ndhB gene impairs cyclic electron flow around photosystem I. Proc Natl Acad Sci USA 95:9705–9709

    Article  PubMed  CAS  Google Scholar 

  • Shimizu H, Shikanai T (2007) Dihydrodipicolinate reductase-like protein, CRR1, is essential for chloroplast NAD(P)H dehydrogenase in Arabidopsis. Plant J 52:539–547

    Article  PubMed  CAS  Google Scholar 

  • Shimizu H, Peng L, Myouga F, Motohashi R, Shinozaki K, Shikanai T (2008) CRR23/NdhL is a subunit of the chloroplast NAD(P)H dehydrogenase complex in Arabidopsis. Plant Cell Physiol 49:835–842

    Article  PubMed  CAS  Google Scholar 

  • Shinozaki K, Ohme M, Tanaka M, Wakasugi T, Hayashida N, Matsubayashi T, Zaita N, Chunwongse J, Obokata J, Yamaguchi-Shinozaki K, Ohto C, Torazawa K, Meng BY, Sugita M, Deno H, Kamogashira T, Yamada K, Kusuda J, Takaiwa F, Kato A, Tohdoh N, Shimada H, Sugiura M (1986) The complete nucleotide sequence of the tobacco chloroplast genome: its gene organization and expression. EMBO J 5:2043–2049

    PubMed  CAS  Google Scholar 

  • Siendones E, Gonzalez-Reyes JA, Santos-Ocana C, Navas P, Cordoba F (1999) Biosynthesis of ascorbic acid in kidney bean. L-galactono-gamma-lactone dehydrogenase is an intrinsic protein located at the mitochondrial inner membrane. Plant Physiol 120:907–912

    Article  PubMed  CAS  Google Scholar 

  • Sirpio S, Allahverdiyeva Y, Holmstrom M, Khrouchtchova A, Haldrup A, Battchikova N, Aro EM (2009a) Novel nuclear-encoded subunits of the chloroplast NAD(P)H dehydrogenase complex. J Biol Chem 284:905–912

    Article  PubMed  CAS  Google Scholar 

  • Sirpio S, Holmstrom M, Battchikova N, Aro EM (2009b) AtCYP20-2 is an auxiliary protein of the chloroplast NAD(P)H dehydrogenase complex. FEBS Lett 583:2355–2358

    Article  PubMed  CAS  Google Scholar 

  • Smirnoff N (2000) Ascorbate biosynthesis and function in photoprotection. Philos Trans R Soc Lond B Biol Sci 355:1455–1464

    Article  PubMed  CAS  Google Scholar 

  • Sugiana C, Pagliarini DJ, McKenzie M, Kirby DM, Salemi R, Abu-Amero KK, Dahl HH, Hutchison WM, Vascotto KA, Smith SM, Newbold RF, Christodoulou J, Calvo S, Mootha VK, Ryan MT, Thorburn DR (2008) Mutation of C20orf7 disrupts complex I assembly and causes lethal neonatal mitochondrial disease. Am J Hum Genet 83:468–478

    Article  PubMed  CAS  Google Scholar 

  • Sugiura C, Kobayashi Y, Aoki S, Sugita C, Sugita M (2003) Complete chloroplast DNA sequence of the moss Physcomitrella patens: evidence for the loss and relocation of rpoA from the chloroplast to the nucleus. Nucleic Acids Res 31:5324–5331

    Article  PubMed  CAS  Google Scholar 

  • Sunderhaus S, Dudkina NV, Jansch L, Klodmann J, Heinemeyer J, Perales M, Zabaleta E, Boekema EJ, Braun HP (2006) Carbonic anhydrase subunits form a matrix-exposed domain attached to the membrane arm of mitochondrial complex I in plants. J Biol Chem 281:6482–6488

    Article  PubMed  CAS  Google Scholar 

  • Suorsa M, Sirpio S, Aro EM (2009) Towards characterization of the chloroplast NAD(P)H dehydrogenase complex. Mol Plant 2:1127–1140

    Article  PubMed  CAS  Google Scholar 

  • Takabayashi A, Ishikawa N, Obayashi T, Ishida S, Obokata J, Endo T, Sato F (2009) Three novel subunits of Arabidopsis chloroplastic NAD(P)H dehydrogenase identified by bioinformatic and reverse genetic approaches. Plant J 57:207–219

    Article  PubMed  CAS  Google Scholar 

  • Triepels R, Smeitink J, Loeffen J, Smeets R, Buskens C, Trijbels F, van den Heuvel L (1999) The human nuclear-encoded acyl carrier subunit (NDUFAB1) of the mitochondrial complex I in human pathology. J Inherit Metab Dis 22:163–173

    Article  PubMed  CAS  Google Scholar 

  • Turmel M, Otis C, Lemieux C (1999) The complete chloroplast DNA sequence of the green alga Nephroselmis olivacea: insights into the architecture of ancestral chloroplast genomes. Proc Natl Acad Sci USA 96:10248–10253

    Article  PubMed  CAS  Google Scholar 

  • Ugalde C, Vogel R, Huijbens R, Van Den Heuvel B, Smeitink J, Nijtmans L (2004) Human mitochondrial complex I assembles through the combination of evolutionary conserved modules: a framework to interpret complex I deficiencies. Hum Mol Genet 13:2461–2472

    Article  PubMed  CAS  Google Scholar 

  • van Lis R, Atteia A, Mendoza-Hernandez G, Gonzalez-Halphen D (2003) Identification of novel mitochondrial protein components of Chlamydomonas reinhardtii. A proteomic approach. Plant Physiol 132:318–330

    Article  PubMed  CAS  Google Scholar 

  • Vidal G, Ribas-Carbo M, Garmier M, Dubertret G, Rasmusson AG, Mathieu C, Foyer CH, De Paepe R (2007) Lack of respiratory chain complex I impairs alternative oxidase engagement and modulates redox signaling during elicitor-induced cell death in tobacco. Plant Cell 19:640–655

    Article  PubMed  CAS  Google Scholar 

  • Videira A, Duarte M (2002) From NADH to ubiquinone in Neurospora mitochondria. Biochim Biophys Acta 1555:187–191

    Article  PubMed  CAS  Google Scholar 

  • Villarreal F, Martin V, Colaneri A, Gonzalez-Schain N, Perales M, Martin M, Lombardo C, Braun HP, Bartoli C, Zabaleta E (2009) Ectopic expression of mitochondrial gamma carbonic anhydrase 2 causes male sterility by anther indehiscence. Plant Mol Biol 70:471–485

    Article  PubMed  CAS  Google Scholar 

  • Vogel RO, Smeitink JA, Nijtmans LG (2007a) Human mitochondrial complex I assembly: a dynamic and versatile process. Biochim Biophys Acta 1767:1215–1227

    Article  PubMed  CAS  Google Scholar 

  • Vogel RO, van den Brand MA, Rodenburg RJ, van den Heuvel LP, Tsuneoka M, Smeitink JA, Nijtmans LG (2007b) Investigation of the complex I assembly chaperones B17.2L and NDUFAF1 in a cohort of CI deficient patients. Mol Genet Metab 91:176–182

    Article  PubMed  CAS  Google Scholar 

  • Wakasugi T, Tsudzuki J, Ito S, Nakashima K, Tsudzuki T, Sugiura M (1994) Loss of all ndh genes as determined by sequencing the entire chloroplast genome of the black pine Pinus thunbergii. Proc Natl Acad Sci USA 91:9794–9798

    Article  PubMed  CAS  Google Scholar 

  • Wakasugi T, Nagai T, Kapoor M, Sugita M, Ito M, Ito S, Tsudzuki J, Nakashima K, Tsudzuki T, Suzuki Y, Hamada A, Ohta T, Inamura A, Yoshinaga K, Sugiura M (1997) Complete nucleotide sequence of the chloroplast genome from the green alga Chlorella vulgaris: the existence of genes possibly involved in chloroplast division. Proc Natl Acad Sci USA 94:5967–5972

    Article  PubMed  CAS  Google Scholar 

  • Wang D, Portis AR Jr (2007) A novel nucleus-encoded chloroplast protein, PIFI, is involved in NAD(P)H dehydrogenase complex-mediated chlororespiratory electron transport in Arabidopsis. Plant Physiol 144:1742–1752

    Article  PubMed  CAS  Google Scholar 

  • Wu D, Wright DA, Wetzel C, Voytas DF, Rodermel S (1999) The IMMUTANS variegation locus of Arabidopsis defines a mitochondrial alternative oxidase homolog that functions during early chloroplast biogenesis. Plant Cell 11:43–55

    Article  PubMed  CAS  Google Scholar 

  • Yamamoto H, Peng L, Fukao Y, Shikanai T (2011) An Src homology 3 domain-like fold protein forms a ferredoxin binding site for the chloroplast NADH dehydrogenase-like complex in Arabidopsis. Plant Cell 23:1480–1493

    Article  PubMed  CAS  Google Scholar 

  • Zensen R, Husmann H, Schneider R, Peine T, Weiss H (1992) De novo synthesis and desaturation of fatty acids at the mitochondrial acyl-carrier protein, a subunit of NADH:ubiquinone oxidoreductase in Neurospora crassa. FEBS Lett 310:179–181

    Article  PubMed  CAS  Google Scholar 

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Acknowledgements

Work on Chlamydomonas complex I was supported by a grant from the United Mitochondrial Disease Foundation (PH, CR) and FRS-FNRS 1.5.255.08 (CR), 2.4601.08 (CR), 1.5.103.10 (PC), 1.C057.09 (PC) and Action de la Recherche Concertée ARC07/12 -04 (CR). VL is supported by a FRIA fellowship. PC is a research associate from FRS-FNRS. We thank Dr. R. Lamb for critical reading of the manuscript.

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  1. Laboratory of Genetics of Microorganisms, Institute of Botany B22, University of Liège, B-4000, Liège, Belgium

    Claire Remacle, Véronique Larosa & Pierre Cardol

  2. Department of Molecular Genetics and Department of Molecular and Cellular Biochemistry, 500 Aronoff Laboratory, 318 W 12th Ave., Columbus, OH, 43210, USA

    Patrice Hamel & Nitya Subrahmanian

  3. Plant Cellular and Molecular Biology Graduate Program, The Ohio State University, Columbus, OH, USA

    Patrice Hamel & Nitya Subrahmanian

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  1. Claire Remacle
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  5. Pierre Cardol
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Correspondence to Claire Remacle or Patrice Hamel .

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    Leonid Sazanov

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Remacle, C., Hamel, P., Larosa, V., Subrahmanian, N., Cardol, P. (2012). Complexes I in the Green Lineage. In: Sazanov, L. (eds) A Structural Perspective on Respiratory Complex I. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-4138-6_11

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